Morphofunctional changes in the tissue of the brain, liver and kidneys of white rats under the influence of selenium nanocomposite encapsulated in the polymer matrix of arabinogalactan

Introduction. Due to their high biocompatibility, substances based on nanosized selenium particles, encapsulated in natural or synthetic polymer matrices, are promising materials for the creation of biomedical preparations of diagnostic and therapeutic value. Selenium nanoparticles are successfully...

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Autores principales:	E. A. Titov, V. S. Rukavishnikov, L. M. Sosedova, M. A. Novikov, E. V. Buynova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2021
Materias:	nanocomposite selenium liver kidneys brain Science Q
Acceso en línea:	https://doaj.org/article/fe9b991b50d646bd800ba232ea8aca82
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spelling	oai:doaj.org-article:fe9b991b50d646bd800ba232ea8aca822021-11-23T06:14:46ZMorphofunctional changes in the tissue of the brain, liver and kidneys of white rats under the influence of selenium nanocomposite encapsulated in the polymer matrix of arabinogalactan2541-94202587-959610.29413/ABS.2021-6.5.9https://doaj.org/article/fe9b991b50d646bd800ba232ea8aca822021-11-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/3039https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Introduction. Due to their high biocompatibility, substances based on nanosized selenium particles, encapsulated in natural or synthetic polymer matrices, are promising materials for the creation of biomedical preparations of diagnostic and therapeutic value. Selenium nanoparticles are successfully used in the diagnosis of various types of cancer. In addition to the diagnostic value, selenium nanoparticles have their own prophylactic and oncological effect. This paper presents the results of a study of the toxicity of the Se nanocomposite encapsulated in the polymer matrix of arabinogalactan (SeAG). The emergence and development of the pathological process in the tissue of the brain, liver and kidneys during subacute administration of this nanocomposite was studied.Materials and methods. Twenty white outbred male rats weighing 200–220 g were used in the work. Animals were orally administered a solution of the selenium nanocomposite at a dose of 500 μg per kilogram of animal body weight for 10 days. Then, using the methods of histological analysis, the severity of the biological response of the organism to the introduction of this nanocomposite was assessed. An analysis of the state of the tissue of the liver, kidneys and the sensorimotor cortex of the brain was carried out.Results. With the intragastric administration of this drug, there is stasis of blood in the portal tracts, a pronounced macrophage reaction and diapedesis of leukocytes in the liver tissue. There is a decrease in the number of normal neurons per unit area, a decrease in the number of astroglia cells and an increase in the number of degeneratively altered neurons in the tissue of the sensorimotor cortex. There is also an increase in connective tissue in the cortex of the kidney, with the formation of fibrosis and a decrease in the area of the Shumlyansky – Bowman capsule.Conclusion. The effect of the investigated nanocomposite is characterized by the development of a pronounced pathological process in the central nervous and hepatorenal systems of the body.E. A. TitovV. S. RukavishnikovL. M. SosedovaM. A. NovikovE. V. BuynovaScientific Сentre for Family Health and Human Reproduction ProblemsarticlenanocompositeseleniumliverkidneysbrainScienceQRUActa Biomedica Scientifica, Vol 6, Iss 5, Pp 92-99 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	nanocomposite selenium liver kidneys brain Science Q
spellingShingle	nanocomposite selenium liver kidneys brain Science Q E. A. Titov V. S. Rukavishnikov L. M. Sosedova M. A. Novikov E. V. Buynova Morphofunctional changes in the tissue of the brain, liver and kidneys of white rats under the influence of selenium nanocomposite encapsulated in the polymer matrix of arabinogalactan
description	Introduction. Due to their high biocompatibility, substances based on nanosized selenium particles, encapsulated in natural or synthetic polymer matrices, are promising materials for the creation of biomedical preparations of diagnostic and therapeutic value. Selenium nanoparticles are successfully used in the diagnosis of various types of cancer. In addition to the diagnostic value, selenium nanoparticles have their own prophylactic and oncological effect. This paper presents the results of a study of the toxicity of the Se nanocomposite encapsulated in the polymer matrix of arabinogalactan (SeAG). The emergence and development of the pathological process in the tissue of the brain, liver and kidneys during subacute administration of this nanocomposite was studied.Materials and methods. Twenty white outbred male rats weighing 200–220 g were used in the work. Animals were orally administered a solution of the selenium nanocomposite at a dose of 500 μg per kilogram of animal body weight for 10 days. Then, using the methods of histological analysis, the severity of the biological response of the organism to the introduction of this nanocomposite was assessed. An analysis of the state of the tissue of the liver, kidneys and the sensorimotor cortex of the brain was carried out.Results. With the intragastric administration of this drug, there is stasis of blood in the portal tracts, a pronounced macrophage reaction and diapedesis of leukocytes in the liver tissue. There is a decrease in the number of normal neurons per unit area, a decrease in the number of astroglia cells and an increase in the number of degeneratively altered neurons in the tissue of the sensorimotor cortex. There is also an increase in connective tissue in the cortex of the kidney, with the formation of fibrosis and a decrease in the area of the Shumlyansky – Bowman capsule.Conclusion. The effect of the investigated nanocomposite is characterized by the development of a pronounced pathological process in the central nervous and hepatorenal systems of the body.
format	article
author	E. A. Titov V. S. Rukavishnikov L. M. Sosedova M. A. Novikov E. V. Buynova
author_facet	E. A. Titov V. S. Rukavishnikov L. M. Sosedova M. A. Novikov E. V. Buynova
author_sort	E. A. Titov
title	Morphofunctional changes in the tissue of the brain, liver and kidneys of white rats under the influence of selenium nanocomposite encapsulated in the polymer matrix of arabinogalactan
title_short	Morphofunctional changes in the tissue of the brain, liver and kidneys of white rats under the influence of selenium nanocomposite encapsulated in the polymer matrix of arabinogalactan
title_full	Morphofunctional changes in the tissue of the brain, liver and kidneys of white rats under the influence of selenium nanocomposite encapsulated in the polymer matrix of arabinogalactan
title_fullStr	Morphofunctional changes in the tissue of the brain, liver and kidneys of white rats under the influence of selenium nanocomposite encapsulated in the polymer matrix of arabinogalactan
title_full_unstemmed	Morphofunctional changes in the tissue of the brain, liver and kidneys of white rats under the influence of selenium nanocomposite encapsulated in the polymer matrix of arabinogalactan
title_sort	morphofunctional changes in the tissue of the brain, liver and kidneys of white rats under the influence of selenium nanocomposite encapsulated in the polymer matrix of arabinogalactan
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2021
url	https://doaj.org/article/fe9b991b50d646bd800ba232ea8aca82
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Morphofunctional changes in the tissue of the brain, liver and kidneys of white rats under the influence of selenium nanocomposite encapsulated in the polymer matrix of arabinogalactan

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