Impact of the volume of the myelomeningocele sac on imaging, prenatal neurosurgery and motor outcomes: a retrospective cohort study

Abstract To investigate the association of the myelomeningocele (MMC) volume with prenatal and postnatal motor function (MF) in cases who underwent a prenatal repair. Retrospective cohort study (11/2011 to 03/2019) of 63 patients who underwent a prenatal MMC repair (37 fetoscopic, 26 open-hysterotom...

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Autores principales:	Romain Corroenne, Amy R. Mehollin-Ray, Rebecca M. Johnson, William E. Whitehead, Jimmy Espinoza, Jonathan Castillo, Heidi Castillo, Gunes Orman, Roopali Donepudi, Thierry A. G. M. Huisman, Ahmed A. Nassr, Michael A. Belfort, Magdalena Sanz Cortes, Alireza A. Shamshirsaz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fe9f48bb7123482caf616aa53e624faf
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spelling	oai:doaj.org-article:fe9f48bb7123482caf616aa53e624faf2021-12-02T17:12:17ZImpact of the volume of the myelomeningocele sac on imaging, prenatal neurosurgery and motor outcomes: a retrospective cohort study10.1038/s41598-021-92739-22045-2322https://doaj.org/article/fe9f48bb7123482caf616aa53e624faf2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92739-2https://doaj.org/toc/2045-2322Abstract To investigate the association of the myelomeningocele (MMC) volume with prenatal and postnatal motor function (MF) in cases who underwent a prenatal repair. Retrospective cohort study (11/2011 to 03/2019) of 63 patients who underwent a prenatal MMC repair (37 fetoscopic, 26 open-hysterotomy). At referral, measurements of the volume of MMC was performed based on ultrasound scans. A large MMC was defined as greater than the optimal volume threshold (ROC analysis) for the prediction of intact MF at referral (2.7 cc). Prenatal or postnatal intact motor function (S1) was defined as the observation of plantar flexion of the ankle based on ultrasound scan or postnatal examination. 23/63 participants presented a large MMC. Large MMC lesions was associated with an increased risk of having clubfeet by 9.5 times (CI%95[2.1–41.8], p < 0.01), and reduces the chances of having an intact MF at referral by 0.19 times (CI%95[0.1–0.6], p < 0.01). At birth, a large MMC reduces the chance of having an intact MF by 0.09 times (CI%95[0.01–0.49], p < 0.01), and increases the risk of having clubfeet by 3.7 times (CI%95[0.8–18.3], p = 0.11). A lower proportion of intact MF and a higher proportion of clubfeet pre- or postnatally were observed in cases with a large MMC sac who underwent a prenatal repair. Trial registration: Clinicaltrials.gov NCT02230072 and NCT03794011 registered on September 3rd, 2014 and January 4th, 2019.Romain CorroenneAmy R. Mehollin-RayRebecca M. JohnsonWilliam E. WhiteheadJimmy EspinozaJonathan CastilloHeidi CastilloGunes OrmanRoopali DonepudiThierry A. G. M. HuismanAhmed A. NassrMichael A. BelfortMagdalena Sanz CortesAlireza A. ShamshirsazNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Romain Corroenne Amy R. Mehollin-Ray Rebecca M. Johnson William E. Whitehead Jimmy Espinoza Jonathan Castillo Heidi Castillo Gunes Orman Roopali Donepudi Thierry A. G. M. Huisman Ahmed A. Nassr Michael A. Belfort Magdalena Sanz Cortes Alireza A. Shamshirsaz Impact of the volume of the myelomeningocele sac on imaging, prenatal neurosurgery and motor outcomes: a retrospective cohort study
description	Abstract To investigate the association of the myelomeningocele (MMC) volume with prenatal and postnatal motor function (MF) in cases who underwent a prenatal repair. Retrospective cohort study (11/2011 to 03/2019) of 63 patients who underwent a prenatal MMC repair (37 fetoscopic, 26 open-hysterotomy). At referral, measurements of the volume of MMC was performed based on ultrasound scans. A large MMC was defined as greater than the optimal volume threshold (ROC analysis) for the prediction of intact MF at referral (2.7 cc). Prenatal or postnatal intact motor function (S1) was defined as the observation of plantar flexion of the ankle based on ultrasound scan or postnatal examination. 23/63 participants presented a large MMC. Large MMC lesions was associated with an increased risk of having clubfeet by 9.5 times (CI%95[2.1–41.8], p < 0.01), and reduces the chances of having an intact MF at referral by 0.19 times (CI%95[0.1–0.6], p < 0.01). At birth, a large MMC reduces the chance of having an intact MF by 0.09 times (CI%95[0.01–0.49], p < 0.01), and increases the risk of having clubfeet by 3.7 times (CI%95[0.8–18.3], p = 0.11). A lower proportion of intact MF and a higher proportion of clubfeet pre- or postnatally were observed in cases with a large MMC sac who underwent a prenatal repair. Trial registration: Clinicaltrials.gov NCT02230072 and NCT03794011 registered on September 3rd, 2014 and January 4th, 2019.
format	article
author	Romain Corroenne Amy R. Mehollin-Ray Rebecca M. Johnson William E. Whitehead Jimmy Espinoza Jonathan Castillo Heidi Castillo Gunes Orman Roopali Donepudi Thierry A. G. M. Huisman Ahmed A. Nassr Michael A. Belfort Magdalena Sanz Cortes Alireza A. Shamshirsaz
author_facet	Romain Corroenne Amy R. Mehollin-Ray Rebecca M. Johnson William E. Whitehead Jimmy Espinoza Jonathan Castillo Heidi Castillo Gunes Orman Roopali Donepudi Thierry A. G. M. Huisman Ahmed A. Nassr Michael A. Belfort Magdalena Sanz Cortes Alireza A. Shamshirsaz
author_sort	Romain Corroenne
title	Impact of the volume of the myelomeningocele sac on imaging, prenatal neurosurgery and motor outcomes: a retrospective cohort study
title_short	Impact of the volume of the myelomeningocele sac on imaging, prenatal neurosurgery and motor outcomes: a retrospective cohort study
title_full	Impact of the volume of the myelomeningocele sac on imaging, prenatal neurosurgery and motor outcomes: a retrospective cohort study
title_fullStr	Impact of the volume of the myelomeningocele sac on imaging, prenatal neurosurgery and motor outcomes: a retrospective cohort study
title_full_unstemmed	Impact of the volume of the myelomeningocele sac on imaging, prenatal neurosurgery and motor outcomes: a retrospective cohort study
title_sort	impact of the volume of the myelomeningocele sac on imaging, prenatal neurosurgery and motor outcomes: a retrospective cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fe9f48bb7123482caf616aa53e624faf
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Impact of the volume of the myelomeningocele sac on imaging, prenatal neurosurgery and motor outcomes: a retrospective cohort study

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