CD200–CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma

The role of the CD200–CD200R axis in regulating pulmonary inflammation is not completely understood. Here the authors show CD200R is expressed on type 2 innate lymphoid cells (ILC2s), and its engagement by CD200 ameliorates airway hyperreactivity and allergic asthma via inhibition of NF-κB signaling...

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Autores principales:	Pedram Shafiei-Jahani, Doumet Georges Helou, Benjamin P. Hurrell, Emily Howard, Christine Quach, Jacob D. Painter, Lauriane Galle-Treger, Meng Li, Yong-Hwee Eddie Loh, Omid Akbari
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fea260e6f82a47a287a0d596f7eecfe6
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id	oai:doaj.org-article:fea260e6f82a47a287a0d596f7eecfe6
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spelling	oai:doaj.org-article:fea260e6f82a47a287a0d596f7eecfe62021-12-02T14:29:13ZCD200–CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma10.1038/s41467-021-22832-72041-1723https://doaj.org/article/fea260e6f82a47a287a0d596f7eecfe62021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22832-7https://doaj.org/toc/2041-1723The role of the CD200–CD200R axis in regulating pulmonary inflammation is not completely understood. Here the authors show CD200R is expressed on type 2 innate lymphoid cells (ILC2s), and its engagement by CD200 ameliorates airway hyperreactivity and allergic asthma via inhibition of NF-κB signaling.Pedram Shafiei-JahaniDoumet Georges HelouBenjamin P. HurrellEmily HowardChristine QuachJacob D. PainterLauriane Galle-TregerMeng LiYong-Hwee Eddie LohOmid AkbariNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pedram Shafiei-Jahani Doumet Georges Helou Benjamin P. Hurrell Emily Howard Christine Quach Jacob D. Painter Lauriane Galle-Treger Meng Li Yong-Hwee Eddie Loh Omid Akbari CD200–CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma
description	The role of the CD200–CD200R axis in regulating pulmonary inflammation is not completely understood. Here the authors show CD200R is expressed on type 2 innate lymphoid cells (ILC2s), and its engagement by CD200 ameliorates airway hyperreactivity and allergic asthma via inhibition of NF-κB signaling.
format	article
author	Pedram Shafiei-Jahani Doumet Georges Helou Benjamin P. Hurrell Emily Howard Christine Quach Jacob D. Painter Lauriane Galle-Treger Meng Li Yong-Hwee Eddie Loh Omid Akbari
author_facet	Pedram Shafiei-Jahani Doumet Georges Helou Benjamin P. Hurrell Emily Howard Christine Quach Jacob D. Painter Lauriane Galle-Treger Meng Li Yong-Hwee Eddie Loh Omid Akbari
author_sort	Pedram Shafiei-Jahani
title	CD200–CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma
title_short	CD200–CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma
title_full	CD200–CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma
title_fullStr	CD200–CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma
title_full_unstemmed	CD200–CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma
title_sort	cd200–cd200r immune checkpoint engagement regulates ilc2 effector function and ameliorates lung inflammation in asthma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fea260e6f82a47a287a0d596f7eecfe6
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CD200–CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma

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