CD200–CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma

CD200–CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma

The role of the CD200–CD200R axis in regulating pulmonary inflammation is not completely understood. Here the authors show CD200R is expressed on type 2 innate lymphoid cells (ILC2s), and its engagement by CD200 ameliorates airway hyperreactivity and allergic asthma via inhibition of NF-κB signaling...

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Bibliographic Details
Main Authors: Pedram Shafiei-Jahani, Doumet Georges Helou, Benjamin P. Hurrell, Emily Howard, Christine Quach, Jacob D. Painter, Lauriane Galle-Treger, Meng Li, Yong-Hwee Eddie Loh, Omid Akbari
Format: article
Language:EN
Published: Nature Portfolio 2021
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Science
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Online Access:https://doaj.org/article/fea260e6f82a47a287a0d596f7eecfe6
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