Ventricular depolarisation vectors in exercise induced myocardial ischaemia

Abstract Ischaemia reduces membrane excitability and conduction of myocardial depolarisation. This would alter the synergy of electromotive forces that contribute to a resultant force at any instant. Changes in magnitude and direction of resultant forces are reflected in electrocardiographic signals...

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Autores principales:	Cameruddin W. Vellani, Mohammad Yusuf, Sadia Mahmud, Satwat Hashmi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fea2cd0c0bc9401c94b612d4dcf4ac66
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spelling	oai:doaj.org-article:fea2cd0c0bc9401c94b612d4dcf4ac662021-12-02T15:06:06ZVentricular depolarisation vectors in exercise induced myocardial ischaemia10.1038/s41598-017-14865-02045-2322https://doaj.org/article/fea2cd0c0bc9401c94b612d4dcf4ac662017-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-14865-0https://doaj.org/toc/2045-2322Abstract Ischaemia reduces membrane excitability and conduction of myocardial depolarisation. This would alter the synergy of electromotive forces that contribute to a resultant force at any instant. Changes in magnitude and direction of resultant forces are reflected in electrocardiographic signals. Here we show a method for obtaining the coordinates of resultant electrical forces during exercise derived from a bipolar orthogonal lead system for calculation of electrical vectors in three planes. In a trial, analysis of changes in vectors indicated that the extent of reduction in magnitude with exercise was significantly greater in groups of patients categorized by impaired effort tolerance and signs of ischaemia. Measurement of changes in the spectrum of depolarisation vectors during exercise has the potential for non-invasive assessment of myocardial ischaemia. This could be the basis of a portable, low-cost tool for investigation of patients with symptoms suggestive of coronary artery disease.Cameruddin W. VellaniMohammad YusufSadia MahmudSatwat HashmiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cameruddin W. Vellani Mohammad Yusuf Sadia Mahmud Satwat Hashmi Ventricular depolarisation vectors in exercise induced myocardial ischaemia
description	Abstract Ischaemia reduces membrane excitability and conduction of myocardial depolarisation. This would alter the synergy of electromotive forces that contribute to a resultant force at any instant. Changes in magnitude and direction of resultant forces are reflected in electrocardiographic signals. Here we show a method for obtaining the coordinates of resultant electrical forces during exercise derived from a bipolar orthogonal lead system for calculation of electrical vectors in three planes. In a trial, analysis of changes in vectors indicated that the extent of reduction in magnitude with exercise was significantly greater in groups of patients categorized by impaired effort tolerance and signs of ischaemia. Measurement of changes in the spectrum of depolarisation vectors during exercise has the potential for non-invasive assessment of myocardial ischaemia. This could be the basis of a portable, low-cost tool for investigation of patients with symptoms suggestive of coronary artery disease.
format	article
author	Cameruddin W. Vellani Mohammad Yusuf Sadia Mahmud Satwat Hashmi
author_facet	Cameruddin W. Vellani Mohammad Yusuf Sadia Mahmud Satwat Hashmi
author_sort	Cameruddin W. Vellani
title	Ventricular depolarisation vectors in exercise induced myocardial ischaemia
title_short	Ventricular depolarisation vectors in exercise induced myocardial ischaemia
title_full	Ventricular depolarisation vectors in exercise induced myocardial ischaemia
title_fullStr	Ventricular depolarisation vectors in exercise induced myocardial ischaemia
title_full_unstemmed	Ventricular depolarisation vectors in exercise induced myocardial ischaemia
title_sort	ventricular depolarisation vectors in exercise induced myocardial ischaemia
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/fea2cd0c0bc9401c94b612d4dcf4ac66
work_keys_str_mv	AT cameruddinwvellani ventriculardepolarisationvectorsinexerciseinducedmyocardialischaemia AT mohammadyusuf ventriculardepolarisationvectorsinexerciseinducedmyocardialischaemia AT sadiamahmud ventriculardepolarisationvectorsinexerciseinducedmyocardialischaemia AT satwathashmi ventriculardepolarisationvectorsinexerciseinducedmyocardialischaemia
_version_	1718388621318291456

Ventricular depolarisation vectors in exercise induced myocardial ischaemia

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