Antibacterial and Hemocompatible pH-Responsive Hydrogel for Skin Wound Healing Application: In Vitro Drug Release

The treatment of successive skin wounds necessitates meticulous medical procedures. In the care and treatment of skin wounds, hydrogels produced from natural polymers with controlled drug release play a crucial role. Arabinoxylan is a well-known and widely available biological macromolecule. We prod...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Muhammad Umar Aslam Khan, Saiful Izwan Abd Razaq, Hassan Mehboob, Sarish Rehman, Wafa Shamsan Al-Arjan, Rashid Amin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	antibacterial biomaterials biopolymers controlled drug release hemocompatibility kinetics studies Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/fea8c9185647418fb3663a4d384204b7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fea8c9185647418fb3663a4d384204b7
record_format	dspace
spelling	oai:doaj.org-article:fea8c9185647418fb3663a4d384204b72021-11-11T18:44:17ZAntibacterial and Hemocompatible pH-Responsive Hydrogel for Skin Wound Healing Application: In Vitro Drug Release10.3390/polym132137032073-4360https://doaj.org/article/fea8c9185647418fb3663a4d384204b72021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4360/13/21/3703https://doaj.org/toc/2073-4360The treatment of successive skin wounds necessitates meticulous medical procedures. In the care and treatment of skin wounds, hydrogels produced from natural polymers with controlled drug release play a crucial role. Arabinoxylan is a well-known and widely available biological macromolecule. We produced various formulations of blended composite hydrogels (BCHs) from arabinoxylan (ARX), carrageenan (CG), and reduced graphene oxide (rGO) using and cross-linked them with an optimal amount of tetraethyl orthosilicate (TEOS). The structural, morphological, and mechanical behavior of the BCHs samples were determined using Fourier-transform infrared spectroscopy (FT-IR), Scanning electron microscope (SEM), mechanical testing, and wetting, respectively. The swelling and degradation assays were performed in phosphate-buffered saline (PBS) solution and aqueous media. Maximum swelling was observed at pH 7 and the least swelling in basic pH regions. All composite hydrogels were found to be hemocompatible. In vitro, silver sulfadiazine release profile in PBS solution was analyzed via the Franz diffusion method, and maximum drug release (87.9%) was observed in 48 h. The drug release kinetics was studied against different mathematical models (zero-order, first-order, Higuchi, Hixson–Crowell, Korsmeyer–Peppas, and Baker–Lonsdale models) and compared their regression coefficient (R<sup>2</sup>) values. It was observed that drug release follows the Baker–Lonsdale model, as it has the highest value (0.989) of R<sup>2</sup>. Hence, the obtained results indicated that, due to optimized swelling, wetting, and degradation, the blended composite hydrogel BCH-3 could be an essential wound dressing biomaterial for sustained drug release for skin wound care and treatment.Muhammad Umar Aslam KhanSaiful Izwan Abd RazaqHassan MehboobSarish RehmanWafa Shamsan Al-ArjanRashid AminMDPI AGarticleantibacterialbiomaterialsbiopolymerscontrolled drug releasehemocompatibilitykinetics studiesOrganic chemistryQD241-441ENPolymers, Vol 13, Iss 3703, p 3703 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antibacterial biomaterials biopolymers controlled drug release hemocompatibility kinetics studies Organic chemistry QD241-441
spellingShingle	antibacterial biomaterials biopolymers controlled drug release hemocompatibility kinetics studies Organic chemistry QD241-441 Muhammad Umar Aslam Khan Saiful Izwan Abd Razaq Hassan Mehboob Sarish Rehman Wafa Shamsan Al-Arjan Rashid Amin Antibacterial and Hemocompatible pH-Responsive Hydrogel for Skin Wound Healing Application: In Vitro Drug Release
description	The treatment of successive skin wounds necessitates meticulous medical procedures. In the care and treatment of skin wounds, hydrogels produced from natural polymers with controlled drug release play a crucial role. Arabinoxylan is a well-known and widely available biological macromolecule. We produced various formulations of blended composite hydrogels (BCHs) from arabinoxylan (ARX), carrageenan (CG), and reduced graphene oxide (rGO) using and cross-linked them with an optimal amount of tetraethyl orthosilicate (TEOS). The structural, morphological, and mechanical behavior of the BCHs samples were determined using Fourier-transform infrared spectroscopy (FT-IR), Scanning electron microscope (SEM), mechanical testing, and wetting, respectively. The swelling and degradation assays were performed in phosphate-buffered saline (PBS) solution and aqueous media. Maximum swelling was observed at pH 7 and the least swelling in basic pH regions. All composite hydrogels were found to be hemocompatible. In vitro, silver sulfadiazine release profile in PBS solution was analyzed via the Franz diffusion method, and maximum drug release (87.9%) was observed in 48 h. The drug release kinetics was studied against different mathematical models (zero-order, first-order, Higuchi, Hixson–Crowell, Korsmeyer–Peppas, and Baker–Lonsdale models) and compared their regression coefficient (R<sup>2</sup>) values. It was observed that drug release follows the Baker–Lonsdale model, as it has the highest value (0.989) of R<sup>2</sup>. Hence, the obtained results indicated that, due to optimized swelling, wetting, and degradation, the blended composite hydrogel BCH-3 could be an essential wound dressing biomaterial for sustained drug release for skin wound care and treatment.
format	article
author	Muhammad Umar Aslam Khan Saiful Izwan Abd Razaq Hassan Mehboob Sarish Rehman Wafa Shamsan Al-Arjan Rashid Amin
author_facet	Muhammad Umar Aslam Khan Saiful Izwan Abd Razaq Hassan Mehboob Sarish Rehman Wafa Shamsan Al-Arjan Rashid Amin
author_sort	Muhammad Umar Aslam Khan
title	Antibacterial and Hemocompatible pH-Responsive Hydrogel for Skin Wound Healing Application: In Vitro Drug Release
title_short	Antibacterial and Hemocompatible pH-Responsive Hydrogel for Skin Wound Healing Application: In Vitro Drug Release
title_full	Antibacterial and Hemocompatible pH-Responsive Hydrogel for Skin Wound Healing Application: In Vitro Drug Release
title_fullStr	Antibacterial and Hemocompatible pH-Responsive Hydrogel for Skin Wound Healing Application: In Vitro Drug Release
title_full_unstemmed	Antibacterial and Hemocompatible pH-Responsive Hydrogel for Skin Wound Healing Application: In Vitro Drug Release
title_sort	antibacterial and hemocompatible ph-responsive hydrogel for skin wound healing application: in vitro drug release
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/fea8c9185647418fb3663a4d384204b7
work_keys_str_mv	AT muhammadumaraslamkhan antibacterialandhemocompatiblephresponsivehydrogelforskinwoundhealingapplicationinvitrodrugrelease AT saifulizwanabdrazaq antibacterialandhemocompatiblephresponsivehydrogelforskinwoundhealingapplicationinvitrodrugrelease AT hassanmehboob antibacterialandhemocompatiblephresponsivehydrogelforskinwoundhealingapplicationinvitrodrugrelease AT sarishrehman antibacterialandhemocompatiblephresponsivehydrogelforskinwoundhealingapplicationinvitrodrugrelease AT wafashamsanalarjan antibacterialandhemocompatiblephresponsivehydrogelforskinwoundhealingapplicationinvitrodrugrelease AT rashidamin antibacterialandhemocompatiblephresponsivehydrogelforskinwoundhealingapplicationinvitrodrugrelease
_version_	1718431800658755584

Antibacterial and Hemocompatible pH-Responsive Hydrogel for Skin Wound Healing Application: In Vitro Drug Release

Ejemplares similares