Modification of Magnetite Nanoparticles with Triazine-Based Dendrons and Their Application as Drug-Transporting Systems

The following research aims at the synthesis of magnetite nanoparticles functionalized with triazine-based dendrons and the application of the obtained materials as effective sorptive materials dedicated to acidic bioactive compounds. The adopted synthetic approach involved: (1) the synthesis of nan...

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Autores principales:	Mateusz Pawlaczyk, Grzegorz Schroeder
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	triazine-based dendrons magnetite nanoparticles magnetic hybrid materials in vitro drug delivery adsorption Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/fea94ee3dcce4675b90f05e49e894d5e
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spelling	oai:doaj.org-article:fea94ee3dcce4675b90f05e49e894d5e2021-11-11T16:49:47ZModification of Magnetite Nanoparticles with Triazine-Based Dendrons and Their Application as Drug-Transporting Systems10.3390/ijms2221113531422-00671661-6596https://doaj.org/article/fea94ee3dcce4675b90f05e49e894d5e2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11353https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The following research aims at the synthesis of magnetite nanoparticles functionalized with triazine-based dendrons and the application of the obtained materials as effective sorptive materials dedicated to acidic bioactive compounds. The adopted synthetic approach involved: (1) the synthesis of nanosized Fe<sub>3</sub>O<sub>4</sub> particles via classic co-precipitation method, (2) the introduction of amine groups on their surface leading to materials’ precursor, and (3) the final synthesis of branched triazine-based dendrons on the support surface by an iterative reaction between cyanuric chloride (CC) and piperazine (p) or diethylenetriamine (DETA) via nucleophilic substitution. The characterized materials were tested for their adsorptive properties towards folic acid, 18β–glycyrrhetinic acid, and vancomycin, showing high adsorption capacities varying in the ranges of 53.33–401.61, 75.82–223.71, and 68.17–132.45 mg g<sup>−1</sup>, respectively. The formed material–drug complexes were also characterized for the drug-delivery potential, performed as in vitro release studies at pH 2.0 and 7.4, which mimics the physiological conditions. The release profiles showed that the proposed materials are able to deliver up to 95.2% of the drugs within 48 h, which makes them efficient candidates for further biomedical applications.Mateusz PawlaczykGrzegorz SchroederMDPI AGarticletriazine-based dendronsmagnetite nanoparticlesmagnetic hybrid materialsin vitro drug deliveryadsorptionBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11353, p 11353 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	triazine-based dendrons magnetite nanoparticles magnetic hybrid materials in vitro drug delivery adsorption Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	triazine-based dendrons magnetite nanoparticles magnetic hybrid materials in vitro drug delivery adsorption Biology (General) QH301-705.5 Chemistry QD1-999 Mateusz Pawlaczyk Grzegorz Schroeder Modification of Magnetite Nanoparticles with Triazine-Based Dendrons and Their Application as Drug-Transporting Systems
description	The following research aims at the synthesis of magnetite nanoparticles functionalized with triazine-based dendrons and the application of the obtained materials as effective sorptive materials dedicated to acidic bioactive compounds. The adopted synthetic approach involved: (1) the synthesis of nanosized Fe<sub>3</sub>O<sub>4</sub> particles via classic co-precipitation method, (2) the introduction of amine groups on their surface leading to materials’ precursor, and (3) the final synthesis of branched triazine-based dendrons on the support surface by an iterative reaction between cyanuric chloride (CC) and piperazine (p) or diethylenetriamine (DETA) via nucleophilic substitution. The characterized materials were tested for their adsorptive properties towards folic acid, 18β–glycyrrhetinic acid, and vancomycin, showing high adsorption capacities varying in the ranges of 53.33–401.61, 75.82–223.71, and 68.17–132.45 mg g<sup>−1</sup>, respectively. The formed material–drug complexes were also characterized for the drug-delivery potential, performed as in vitro release studies at pH 2.0 and 7.4, which mimics the physiological conditions. The release profiles showed that the proposed materials are able to deliver up to 95.2% of the drugs within 48 h, which makes them efficient candidates for further biomedical applications.
format	article
author	Mateusz Pawlaczyk Grzegorz Schroeder
author_facet	Mateusz Pawlaczyk Grzegorz Schroeder
author_sort	Mateusz Pawlaczyk
title	Modification of Magnetite Nanoparticles with Triazine-Based Dendrons and Their Application as Drug-Transporting Systems
title_short	Modification of Magnetite Nanoparticles with Triazine-Based Dendrons and Their Application as Drug-Transporting Systems
title_full	Modification of Magnetite Nanoparticles with Triazine-Based Dendrons and Their Application as Drug-Transporting Systems
title_fullStr	Modification of Magnetite Nanoparticles with Triazine-Based Dendrons and Their Application as Drug-Transporting Systems
title_full_unstemmed	Modification of Magnetite Nanoparticles with Triazine-Based Dendrons and Their Application as Drug-Transporting Systems
title_sort	modification of magnetite nanoparticles with triazine-based dendrons and their application as drug-transporting systems
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/fea94ee3dcce4675b90f05e49e894d5e
work_keys_str_mv	AT mateuszpawlaczyk modificationofmagnetitenanoparticleswithtriazinebaseddendronsandtheirapplicationasdrugtransportingsystems AT grzegorzschroeder modificationofmagnetitenanoparticleswithtriazinebaseddendronsandtheirapplicationasdrugtransportingsystems
_version_	1718432277441019904

Modification of Magnetite Nanoparticles with Triazine-Based Dendrons and Their Application as Drug-Transporting Systems

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