KLF-1 orchestrates a xenobiotic detoxification program essential for longevity of mitochondrial mutants

Cytochrome P450 oxidases (CYPs) are enzymes that participate in the xenobiotic detoxification and their expression is enhanced in long-lived model organisms. Here the authors show that KLF-1 promotes cyp expression and ensures lifespan extension in C. elegans mitomutants by activating mitohormesis.

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Auteurs principaux:	Marija Herholz, Estela Cepeda, Linda Baumann, Alexandra Kukat, Johannes Hermeling, Sarah Maciej, Karolina Szczepanowska, Victor Pavlenko, Peter Frommolt, Aleksandra Trifunovic
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/feab04d3410f49848f0f76132fec5107
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id	oai:doaj.org-article:feab04d3410f49848f0f76132fec5107
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spelling	oai:doaj.org-article:feab04d3410f49848f0f76132fec51072021-12-02T16:51:00ZKLF-1 orchestrates a xenobiotic detoxification program essential for longevity of mitochondrial mutants10.1038/s41467-019-11275-w2041-1723https://doaj.org/article/feab04d3410f49848f0f76132fec51072019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11275-whttps://doaj.org/toc/2041-1723Cytochrome P450 oxidases (CYPs) are enzymes that participate in the xenobiotic detoxification and their expression is enhanced in long-lived model organisms. Here the authors show that KLF-1 promotes cyp expression and ensures lifespan extension in C. elegans mitomutants by activating mitohormesis.Marija HerholzEstela CepedaLinda BaumannAlexandra KukatJohannes HermelingSarah MaciejKarolina SzczepanowskaVictor PavlenkoPeter FrommoltAleksandra TrifunovicNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marija Herholz Estela Cepeda Linda Baumann Alexandra Kukat Johannes Hermeling Sarah Maciej Karolina Szczepanowska Victor Pavlenko Peter Frommolt Aleksandra Trifunovic KLF-1 orchestrates a xenobiotic detoxification program essential for longevity of mitochondrial mutants
description	Cytochrome P450 oxidases (CYPs) are enzymes that participate in the xenobiotic detoxification and their expression is enhanced in long-lived model organisms. Here the authors show that KLF-1 promotes cyp expression and ensures lifespan extension in C. elegans mitomutants by activating mitohormesis.
format	article
author	Marija Herholz Estela Cepeda Linda Baumann Alexandra Kukat Johannes Hermeling Sarah Maciej Karolina Szczepanowska Victor Pavlenko Peter Frommolt Aleksandra Trifunovic
author_facet	Marija Herholz Estela Cepeda Linda Baumann Alexandra Kukat Johannes Hermeling Sarah Maciej Karolina Szczepanowska Victor Pavlenko Peter Frommolt Aleksandra Trifunovic
author_sort	Marija Herholz
title	KLF-1 orchestrates a xenobiotic detoxification program essential for longevity of mitochondrial mutants
title_short	KLF-1 orchestrates a xenobiotic detoxification program essential for longevity of mitochondrial mutants
title_full	KLF-1 orchestrates a xenobiotic detoxification program essential for longevity of mitochondrial mutants
title_fullStr	KLF-1 orchestrates a xenobiotic detoxification program essential for longevity of mitochondrial mutants
title_full_unstemmed	KLF-1 orchestrates a xenobiotic detoxification program essential for longevity of mitochondrial mutants
title_sort	klf-1 orchestrates a xenobiotic detoxification program essential for longevity of mitochondrial mutants
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/feab04d3410f49848f0f76132fec5107
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KLF-1 orchestrates a xenobiotic detoxification program essential for longevity of mitochondrial mutants

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