The Impact of NLRP3 Activation on Hematopoietic Stem Cell Transplantation

NLR family pyrin domain-containing 3 (NLRP3) is an intracellular protein that after recognizing a broad spectrum of stressors, such as microbial motifs and endogenous danger signals, promotes the activation and release of the pro-inflammatory cytokines IL-1β and IL-18, thus playing an essential role...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	J. Luis Espinoza, Kosuke Kamio, Vu Quang Lam, Akiyoshi Takami
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	inflammasome bone marrow transplantation transplant related mortality NLRP3 genotypes transplant outcomes Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/fead04cbeb774ef09b53919b332f55fa
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fead04cbeb774ef09b53919b332f55fa
record_format	dspace
spelling	oai:doaj.org-article:fead04cbeb774ef09b53919b332f55fa2021-11-11T17:16:26ZThe Impact of NLRP3 Activation on Hematopoietic Stem Cell Transplantation10.3390/ijms2221118451422-00671661-6596https://doaj.org/article/fead04cbeb774ef09b53919b332f55fa2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11845https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067NLR family pyrin domain-containing 3 (NLRP3) is an intracellular protein that after recognizing a broad spectrum of stressors, such as microbial motifs and endogenous danger signals, promotes the activation and release of the pro-inflammatory cytokines IL-1β and IL-18, thus playing an essential role in the innate immune response. Several blood cell types, including macrophages, dendritic cells, and hematopoietic stem and progenitor cells (HSPCs), express NLRP3, where it has been implicated in various physiological and pathological processes. For example, NLRP3 participates in the development and expansion of HSPCs, and their release from bone marrow into the peripheral blood has been implicated in certain hematological disorders including various types of leukemia. In addition, accumulating evidence indicates that activation of NLRP3 plays a pivotal role in the development of transplant complications in patients receiving hematopoietic stem cell transplantation (HSCT) including graft versus host disease, severe infections, and transplant-related mortality. The majority of these complications are triggered by the severe tissue damage derived from the conditioning regimens utilized in HSCT which, in turn, activates NLRP3 and, ultimately, promotes the release of proinflammatory cytokines such as IL-1β and IL-18. Here, we summarize the implications of NLRP3 in HSCT with an emphasis on the involvement of this inflammasome component in transplant complications.J. Luis EspinozaKosuke KamioVu Quang LamAkiyoshi TakamiMDPI AGarticleinflammasomebone marrow transplantationtransplant related mortalityNLRP3 genotypestransplant outcomesBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11845, p 11845 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	inflammasome bone marrow transplantation transplant related mortality NLRP3 genotypes transplant outcomes Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	inflammasome bone marrow transplantation transplant related mortality NLRP3 genotypes transplant outcomes Biology (General) QH301-705.5 Chemistry QD1-999 J. Luis Espinoza Kosuke Kamio Vu Quang Lam Akiyoshi Takami The Impact of NLRP3 Activation on Hematopoietic Stem Cell Transplantation
description	NLR family pyrin domain-containing 3 (NLRP3) is an intracellular protein that after recognizing a broad spectrum of stressors, such as microbial motifs and endogenous danger signals, promotes the activation and release of the pro-inflammatory cytokines IL-1β and IL-18, thus playing an essential role in the innate immune response. Several blood cell types, including macrophages, dendritic cells, and hematopoietic stem and progenitor cells (HSPCs), express NLRP3, where it has been implicated in various physiological and pathological processes. For example, NLRP3 participates in the development and expansion of HSPCs, and their release from bone marrow into the peripheral blood has been implicated in certain hematological disorders including various types of leukemia. In addition, accumulating evidence indicates that activation of NLRP3 plays a pivotal role in the development of transplant complications in patients receiving hematopoietic stem cell transplantation (HSCT) including graft versus host disease, severe infections, and transplant-related mortality. The majority of these complications are triggered by the severe tissue damage derived from the conditioning regimens utilized in HSCT which, in turn, activates NLRP3 and, ultimately, promotes the release of proinflammatory cytokines such as IL-1β and IL-18. Here, we summarize the implications of NLRP3 in HSCT with an emphasis on the involvement of this inflammasome component in transplant complications.
format	article
author	J. Luis Espinoza Kosuke Kamio Vu Quang Lam Akiyoshi Takami
author_facet	J. Luis Espinoza Kosuke Kamio Vu Quang Lam Akiyoshi Takami
author_sort	J. Luis Espinoza
title	The Impact of NLRP3 Activation on Hematopoietic Stem Cell Transplantation
title_short	The Impact of NLRP3 Activation on Hematopoietic Stem Cell Transplantation
title_full	The Impact of NLRP3 Activation on Hematopoietic Stem Cell Transplantation
title_fullStr	The Impact of NLRP3 Activation on Hematopoietic Stem Cell Transplantation
title_full_unstemmed	The Impact of NLRP3 Activation on Hematopoietic Stem Cell Transplantation
title_sort	impact of nlrp3 activation on hematopoietic stem cell transplantation
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/fead04cbeb774ef09b53919b332f55fa
work_keys_str_mv	AT jluisespinoza theimpactofnlrp3activationonhematopoieticstemcelltransplantation AT kosukekamio theimpactofnlrp3activationonhematopoieticstemcelltransplantation AT vuquanglam theimpactofnlrp3activationonhematopoieticstemcelltransplantation AT akiyoshitakami theimpactofnlrp3activationonhematopoieticstemcelltransplantation AT jluisespinoza impactofnlrp3activationonhematopoieticstemcelltransplantation AT kosukekamio impactofnlrp3activationonhematopoieticstemcelltransplantation AT vuquanglam impactofnlrp3activationonhematopoieticstemcelltransplantation AT akiyoshitakami impactofnlrp3activationonhematopoieticstemcelltransplantation
_version_	1718432157087563776

The Impact of NLRP3 Activation on Hematopoietic Stem Cell Transplantation

Ejemplares similares