Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency

Point mutations have been found in induced pluripotent stem cells (iPSCs) but when they arise is unclear. Here, the authors show that a G1/S cell cycle checkpoint deficiency transiently occurs early in genome reprogramming, suggesting a common developmental pathway between iPSC and tumorigenesis, an...

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Autores principales:	Ryoko Araki, Yuko Hoki, Tomo Suga, Chizuka Obara, Misato Sunayama, Kaori Imadome, Mayumi Fujita, Satoshi Kamimura, Miki Nakamura, Sayaka Wakayama, Andras Nagy, Teruhiko Wakayama, Masumi Abe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fead58306cee46a28867f75c35cbe41b
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spelling	oai:doaj.org-article:fead58306cee46a28867f75c35cbe41b2021-12-02T16:49:59ZGenetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency10.1038/s41467-019-13830-x2041-1723https://doaj.org/article/fead58306cee46a28867f75c35cbe41b2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13830-xhttps://doaj.org/toc/2041-1723Point mutations have been found in induced pluripotent stem cells (iPSCs) but when they arise is unclear. Here, the authors show that a G1/S cell cycle checkpoint deficiency transiently occurs early in genome reprogramming, suggesting a common developmental pathway between iPSC and tumorigenesis, and generate genetic burden-free human iPSCs.Ryoko ArakiYuko HokiTomo SugaChizuka ObaraMisato SunayamaKaori ImadomeMayumi FujitaSatoshi KamimuraMiki NakamuraSayaka WakayamaAndras NagyTeruhiko WakayamaMasumi AbeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ryoko Araki Yuko Hoki Tomo Suga Chizuka Obara Misato Sunayama Kaori Imadome Mayumi Fujita Satoshi Kamimura Miki Nakamura Sayaka Wakayama Andras Nagy Teruhiko Wakayama Masumi Abe Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency
description	Point mutations have been found in induced pluripotent stem cells (iPSCs) but when they arise is unclear. Here, the authors show that a G1/S cell cycle checkpoint deficiency transiently occurs early in genome reprogramming, suggesting a common developmental pathway between iPSC and tumorigenesis, and generate genetic burden-free human iPSCs.
format	article
author	Ryoko Araki Yuko Hoki Tomo Suga Chizuka Obara Misato Sunayama Kaori Imadome Mayumi Fujita Satoshi Kamimura Miki Nakamura Sayaka Wakayama Andras Nagy Teruhiko Wakayama Masumi Abe
author_facet	Ryoko Araki Yuko Hoki Tomo Suga Chizuka Obara Misato Sunayama Kaori Imadome Mayumi Fujita Satoshi Kamimura Miki Nakamura Sayaka Wakayama Andras Nagy Teruhiko Wakayama Masumi Abe
author_sort	Ryoko Araki
title	Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency
title_short	Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency
title_full	Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency
title_fullStr	Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency
title_full_unstemmed	Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency
title_sort	genetic aberrations in ipscs are introduced by a transient g1/s cell cycle checkpoint deficiency
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/fead58306cee46a28867f75c35cbe41b
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Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency

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