Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency

Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency

Point mutations have been found in induced pluripotent stem cells (iPSCs) but when they arise is unclear. Here, the authors show that a G1/S cell cycle checkpoint deficiency transiently occurs early in genome reprogramming, suggesting a common developmental pathway between iPSC and tumorigenesis, an...

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Autores principales: Ryoko Araki, Yuko Hoki, Tomo Suga, Chizuka Obara, Misato Sunayama, Kaori Imadome, Mayumi Fujita, Satoshi Kamimura, Miki Nakamura, Sayaka Wakayama, Andras Nagy, Teruhiko Wakayama, Masumi Abe
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/fead58306cee46a28867f75c35cbe41b
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