Genomic Analysis of the Emergence of Vancomycin-Resistant <named-content content-type="genus-species">Staphylococcus aureus</named-content>

ABSTRACT Staphylococcus aureus is a human commensal bacterium and a prominent cause of infections globally. The high incidence of S. aureus infections is compounded by the ability of the microbe to readily acquire resistance to antibiotics. In the United States, methicillin-resistant S. aureus (MRSA...

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Autores principales:	Scott D. Kobayashi, James M. Musser, Frank R. DeLeo
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2012
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/feaed35dee324f7190141426a9482551
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spelling	oai:doaj.org-article:feaed35dee324f7190141426a94825512021-11-15T15:39:10ZGenomic Analysis of the Emergence of Vancomycin-Resistant <named-content content-type="genus-species">Staphylococcus aureus</named-content>10.1128/mBio.00170-122150-7511https://doaj.org/article/feaed35dee324f7190141426a94825512012-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00170-12https://doaj.org/toc/2150-7511ABSTRACT Staphylococcus aureus is a human commensal bacterium and a prominent cause of infections globally. The high incidence of S. aureus infections is compounded by the ability of the microbe to readily acquire resistance to antibiotics. In the United States, methicillin-resistant S. aureus (MRSA) is a leading cause of morbidity and mortality by a single infectious agent. Therapeutic options for severe MRSA infections are limited to a few antibiotics to which the organism is typically susceptible, including vancomycin. Acquisition of high-level vancomycin resistance by MRSA is a major concern, but to date, there have been only 12 vancomycin-resistant S. aureus (VRSA) isolates reported in the United States and all belong to a phylogenetic lineage known as clonal complex 5. To gain enhanced understanding of the genetic characteristics conducive to the acquisition of vancomycin resistance by S. aureus, V. N. Kos et al. performed whole-genome sequencing of all 12 VRSA isolates and compared the DNA sequences to the genomes of other S. aureus strains. The findings provide new information about the evolutionary history of VRSA and identify genetic features that may bear on the relationship between S. aureus clonal complex 5 strains and the acquisition of vancomycin resistance genes from enterococci.Scott D. KobayashiJames M. MusserFrank R. DeLeoAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 3, Iss 4 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Scott D. Kobayashi James M. Musser Frank R. DeLeo Genomic Analysis of the Emergence of Vancomycin-Resistant <named-content content-type="genus-species">Staphylococcus aureus</named-content>
description	ABSTRACT Staphylococcus aureus is a human commensal bacterium and a prominent cause of infections globally. The high incidence of S. aureus infections is compounded by the ability of the microbe to readily acquire resistance to antibiotics. In the United States, methicillin-resistant S. aureus (MRSA) is a leading cause of morbidity and mortality by a single infectious agent. Therapeutic options for severe MRSA infections are limited to a few antibiotics to which the organism is typically susceptible, including vancomycin. Acquisition of high-level vancomycin resistance by MRSA is a major concern, but to date, there have been only 12 vancomycin-resistant S. aureus (VRSA) isolates reported in the United States and all belong to a phylogenetic lineage known as clonal complex 5. To gain enhanced understanding of the genetic characteristics conducive to the acquisition of vancomycin resistance by S. aureus, V. N. Kos et al. performed whole-genome sequencing of all 12 VRSA isolates and compared the DNA sequences to the genomes of other S. aureus strains. The findings provide new information about the evolutionary history of VRSA and identify genetic features that may bear on the relationship between S. aureus clonal complex 5 strains and the acquisition of vancomycin resistance genes from enterococci.
format	article
author	Scott D. Kobayashi James M. Musser Frank R. DeLeo
author_facet	Scott D. Kobayashi James M. Musser Frank R. DeLeo
author_sort	Scott D. Kobayashi
title	Genomic Analysis of the Emergence of Vancomycin-Resistant <named-content content-type="genus-species">Staphylococcus aureus</named-content>
title_short	Genomic Analysis of the Emergence of Vancomycin-Resistant <named-content content-type="genus-species">Staphylococcus aureus</named-content>
title_full	Genomic Analysis of the Emergence of Vancomycin-Resistant <named-content content-type="genus-species">Staphylococcus aureus</named-content>
title_fullStr	Genomic Analysis of the Emergence of Vancomycin-Resistant <named-content content-type="genus-species">Staphylococcus aureus</named-content>
title_full_unstemmed	Genomic Analysis of the Emergence of Vancomycin-Resistant <named-content content-type="genus-species">Staphylococcus aureus</named-content>
title_sort	genomic analysis of the emergence of vancomycin-resistant <named-content content-type="genus-species">staphylococcus aureus</named-content>
publisher	American Society for Microbiology
publishDate	2012
url	https://doaj.org/article/feaed35dee324f7190141426a9482551
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Genomic Analysis of the Emergence of Vancomycin-Resistant <named-content content-type="genus-species">Staphylococcus aureus</named-content>

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