Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection
Negative selection removes deleterious genetic variation, and can influence genetic architectures and evolution of complex traits. Here, the authors analyze data from 25 UK Biobank diseases and complex traits, and quantify frequency-dependent genetic architectures which suggests actions of negative...
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Nature Portfolio
2019
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oai:doaj.org-article:feb2ef5b1d054956892103cae50e6b532021-12-02T14:39:20ZQuantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection10.1038/s41467-019-08424-62041-1723https://doaj.org/article/feb2ef5b1d054956892103cae50e6b532019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08424-6https://doaj.org/toc/2041-1723Negative selection removes deleterious genetic variation, and can influence genetic architectures and evolution of complex traits. Here, the authors analyze data from 25 UK Biobank diseases and complex traits, and quantify frequency-dependent genetic architectures which suggests actions of negative selection.Armin P. SchoechDaniel M. JordanPo-Ru LohSteven GazalLuke J. O’ConnorDaniel J. BalickPier F. PalamaraHilary K. FinucaneShamil R. SunyaevAlkes L. PriceNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019) |
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Science Q Armin P. Schoech Daniel M. Jordan Po-Ru Loh Steven Gazal Luke J. O’Connor Daniel J. Balick Pier F. Palamara Hilary K. Finucane Shamil R. Sunyaev Alkes L. Price Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection |
description |
Negative selection removes deleterious genetic variation, and can influence genetic architectures and evolution of complex traits. Here, the authors analyze data from 25 UK Biobank diseases and complex traits, and quantify frequency-dependent genetic architectures which suggests actions of negative selection. |
format |
article |
author |
Armin P. Schoech Daniel M. Jordan Po-Ru Loh Steven Gazal Luke J. O’Connor Daniel J. Balick Pier F. Palamara Hilary K. Finucane Shamil R. Sunyaev Alkes L. Price |
author_facet |
Armin P. Schoech Daniel M. Jordan Po-Ru Loh Steven Gazal Luke J. O’Connor Daniel J. Balick Pier F. Palamara Hilary K. Finucane Shamil R. Sunyaev Alkes L. Price |
author_sort |
Armin P. Schoech |
title |
Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection |
title_short |
Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection |
title_full |
Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection |
title_fullStr |
Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection |
title_full_unstemmed |
Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection |
title_sort |
quantification of frequency-dependent genetic architectures in 25 uk biobank traits reveals action of negative selection |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/feb2ef5b1d054956892103cae50e6b53 |
work_keys_str_mv |
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