Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection

Negative selection removes deleterious genetic variation, and can influence genetic architectures and evolution of complex traits. Here, the authors analyze data from 25 UK Biobank diseases and complex traits, and quantify frequency-dependent genetic architectures which suggests actions of negative...

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Autores principales: Armin P. Schoech, Daniel M. Jordan, Po-Ru Loh, Steven Gazal, Luke J. O’Connor, Daniel J. Balick, Pier F. Palamara, Hilary K. Finucane, Shamil R. Sunyaev, Alkes L. Price
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/feb2ef5b1d054956892103cae50e6b53
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spelling oai:doaj.org-article:feb2ef5b1d054956892103cae50e6b532021-12-02T14:39:20ZQuantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection10.1038/s41467-019-08424-62041-1723https://doaj.org/article/feb2ef5b1d054956892103cae50e6b532019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08424-6https://doaj.org/toc/2041-1723Negative selection removes deleterious genetic variation, and can influence genetic architectures and evolution of complex traits. Here, the authors analyze data from 25 UK Biobank diseases and complex traits, and quantify frequency-dependent genetic architectures which suggests actions of negative selection.Armin P. SchoechDaniel M. JordanPo-Ru LohSteven GazalLuke J. O’ConnorDaniel J. BalickPier F. PalamaraHilary K. FinucaneShamil R. SunyaevAlkes L. PriceNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Armin P. Schoech
Daniel M. Jordan
Po-Ru Loh
Steven Gazal
Luke J. O’Connor
Daniel J. Balick
Pier F. Palamara
Hilary K. Finucane
Shamil R. Sunyaev
Alkes L. Price
Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection
description Negative selection removes deleterious genetic variation, and can influence genetic architectures and evolution of complex traits. Here, the authors analyze data from 25 UK Biobank diseases and complex traits, and quantify frequency-dependent genetic architectures which suggests actions of negative selection.
format article
author Armin P. Schoech
Daniel M. Jordan
Po-Ru Loh
Steven Gazal
Luke J. O’Connor
Daniel J. Balick
Pier F. Palamara
Hilary K. Finucane
Shamil R. Sunyaev
Alkes L. Price
author_facet Armin P. Schoech
Daniel M. Jordan
Po-Ru Loh
Steven Gazal
Luke J. O’Connor
Daniel J. Balick
Pier F. Palamara
Hilary K. Finucane
Shamil R. Sunyaev
Alkes L. Price
author_sort Armin P. Schoech
title Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection
title_short Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection
title_full Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection
title_fullStr Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection
title_full_unstemmed Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection
title_sort quantification of frequency-dependent genetic architectures in 25 uk biobank traits reveals action of negative selection
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/feb2ef5b1d054956892103cae50e6b53
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