A unified drug–target interaction prediction framework based on knowledge graph and recommendation system

Prediction of drug-target interactions (DTI) plays a vital role in drug development through applications in various areas, such as virtual screening for lead discovery, drug repurposing and identification of potential drug side effects. Here, the authors develop a unified framework for DTI predictio...

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Autores principales: Qing Ye, Chang-Yu Hsieh, Ziyi Yang, Yu Kang, Jiming Chen, Dongsheng Cao, Shibo He, Tingjun Hou
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/feb43093b20a4dbf8bf7f4189d80feff
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Sumario:Prediction of drug-target interactions (DTI) plays a vital role in drug development through applications in various areas, such as virtual screening for lead discovery, drug repurposing and identification of potential drug side effects. Here, the authors develop a unified framework for DTI prediction by combining a knowledge graph and a recommendation system.