Dietary excess regulates absorption and surface of gut epithelium through intestinal PPARα

Dietary excess regulates absorption and surface of gut epithelium through intestinal PPARα

Intestinal surface changes in size and function, but what propels these alterations is unknown. Here, the authors show that food excess increases the gut absorptive capacity, and that in presence of dietary lipids, intestinal PPARα is indispensable for the adaptive increase in villi length and funct...

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Autores principales: Ozren Stojanović, Jordi Altirriba, Dorothée Rigo, Martina Spiljar, Emilien Evrard, Benedek Roska, Salvatore Fabbiano, Nicola Zamboni, Pierre Maechler, Françoise Rohner-Jeanrenaud, Mirko Trajkovski
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Q
Acceso en línea:https://doaj.org/article/feb666dbd139462abeb8a6b7336b6351
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spelling oai:doaj.org-article:feb666dbd139462abeb8a6b7336b63512021-12-05T12:22:22ZDietary excess regulates absorption and surface of gut epithelium through intestinal PPARα10.1038/s41467-021-27133-72041-1723https://doaj.org/article/feb666dbd139462abeb8a6b7336b63512021-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27133-7https://doaj.org/toc/2041-1723Intestinal surface changes in size and function, but what propels these alterations is unknown. Here, the authors show that food excess increases the gut absorptive capacity, and that in presence of dietary lipids, intestinal PPARα is indispensable for the adaptive increase in villi length and function.Ozren StojanovićJordi AltirribaDorothée RigoMartina SpiljarEmilien EvrardBenedek RoskaSalvatore FabbianoNicola ZamboniPierre MaechlerFrançoise Rohner-JeanrenaudMirko TrajkovskiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ozren Stojanović
Jordi Altirriba
Dorothée Rigo
Martina Spiljar
Emilien Evrard
Benedek Roska
Salvatore Fabbiano
Nicola Zamboni
Pierre Maechler
Françoise Rohner-Jeanrenaud
Mirko Trajkovski
Dietary excess regulates absorption and surface of gut epithelium through intestinal PPARα
description Intestinal surface changes in size and function, but what propels these alterations is unknown. Here, the authors show that food excess increases the gut absorptive capacity, and that in presence of dietary lipids, intestinal PPARα is indispensable for the adaptive increase in villi length and function.
format article
author Ozren Stojanović
Jordi Altirriba
Dorothée Rigo
Martina Spiljar
Emilien Evrard
Benedek Roska
Salvatore Fabbiano
Nicola Zamboni
Pierre Maechler
Françoise Rohner-Jeanrenaud
Mirko Trajkovski
author_facet Ozren Stojanović
Jordi Altirriba
Dorothée Rigo
Martina Spiljar
Emilien Evrard
Benedek Roska
Salvatore Fabbiano
Nicola Zamboni
Pierre Maechler
Françoise Rohner-Jeanrenaud
Mirko Trajkovski
author_sort Ozren Stojanović
title Dietary excess regulates absorption and surface of gut epithelium through intestinal PPARα
title_short Dietary excess regulates absorption and surface of gut epithelium through intestinal PPARα
title_full Dietary excess regulates absorption and surface of gut epithelium through intestinal PPARα
title_fullStr Dietary excess regulates absorption and surface of gut epithelium through intestinal PPARα
title_full_unstemmed Dietary excess regulates absorption and surface of gut epithelium through intestinal PPARα
title_sort dietary excess regulates absorption and surface of gut epithelium through intestinal pparα
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/feb666dbd139462abeb8a6b7336b6351
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AT jordialtirriba dietaryexcessregulatesabsorptionandsurfaceofgutepitheliumthroughintestinalppara
AT dorotheerigo dietaryexcessregulatesabsorptionandsurfaceofgutepitheliumthroughintestinalppara
AT martinaspiljar dietaryexcessregulatesabsorptionandsurfaceofgutepitheliumthroughintestinalppara
AT emilienevrard dietaryexcessregulatesabsorptionandsurfaceofgutepitheliumthroughintestinalppara
AT benedekroska dietaryexcessregulatesabsorptionandsurfaceofgutepitheliumthroughintestinalppara
AT salvatorefabbiano dietaryexcessregulatesabsorptionandsurfaceofgutepitheliumthroughintestinalppara
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AT francoiserohnerjeanrenaud dietaryexcessregulatesabsorptionandsurfaceofgutepitheliumthroughintestinalppara
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