Aberrant telomere length and mitochondrial DNA copy number in suicide completers

Abstract Short telomere length (TL) occurs in individuals under psychological stress, and with various psychiatric diseases. Recent studies have also reported mitochondrial DNA copy number (mtDNAcn) alterations under several neuropsychiatric conditions. However, no study has examined whether aberran...

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Autores principales:	Ikuo Otsuka, Takeshi Izumi, Shuken Boku, Atsushi Kimura, Yuan Zhang, Kentaro Mouri, Satoshi Okazaki, Kyoichi Shiroiwa, Motonori Takahashi, Yasuhiro Ueno, Osamu Shirakawa, Ichiro Sora, Akitoyo Hishimoto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/feba59d0afea4c6b90b620a9083fb79c
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spelling	oai:doaj.org-article:feba59d0afea4c6b90b620a9083fb79c2021-12-02T15:06:00ZAberrant telomere length and mitochondrial DNA copy number in suicide completers10.1038/s41598-017-03599-82045-2322https://doaj.org/article/feba59d0afea4c6b90b620a9083fb79c2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03599-8https://doaj.org/toc/2045-2322Abstract Short telomere length (TL) occurs in individuals under psychological stress, and with various psychiatric diseases. Recent studies have also reported mitochondrial DNA copy number (mtDNAcn) alterations under several neuropsychiatric conditions. However, no study has examined whether aberrant TL or mtDNAcn occur in completed suicide, one of the most serious outcomes of mental illnesses. TL and mtDNAcn in post-mortem samples from 528 suicide completers without severe physical illness (508 peripheral bloods; 20 brains) and 560 samples from control subjects (peripheral bloods from 535 healthy individuals; 25 post-mortem brains) were analysed by quantitative polymerase chain reaction. Suicide completers had significantly shorter TL and higher mtDNAcn of peripheral bloods with sex/age-dependent differences (shorter TL was more remarkably in female/young suicides; higher mtDNAcn more so in male/elderly suicides). The normal age-related decline of TL and mtDNAcn were significantly altered in suicide completers. Furthermore, shorter TL and lower mtDNAcn of post-mortem prefrontal cortex were seen in suicide completers compared to controls. This study shows the first association of aberrant telomeres and mtDNA content with suicide completion. Our results indicate that further research on telomere shortening and mitochondrial dysfunction may help elucidate the molecular underpinnings of suicide-related pathophysiology.Ikuo OtsukaTakeshi IzumiShuken BokuAtsushi KimuraYuan ZhangKentaro MouriSatoshi OkazakiKyoichi ShiroiwaMotonori TakahashiYasuhiro UenoOsamu ShirakawaIchiro SoraAkitoyo HishimotoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ikuo Otsuka Takeshi Izumi Shuken Boku Atsushi Kimura Yuan Zhang Kentaro Mouri Satoshi Okazaki Kyoichi Shiroiwa Motonori Takahashi Yasuhiro Ueno Osamu Shirakawa Ichiro Sora Akitoyo Hishimoto Aberrant telomere length and mitochondrial DNA copy number in suicide completers
description	Abstract Short telomere length (TL) occurs in individuals under psychological stress, and with various psychiatric diseases. Recent studies have also reported mitochondrial DNA copy number (mtDNAcn) alterations under several neuropsychiatric conditions. However, no study has examined whether aberrant TL or mtDNAcn occur in completed suicide, one of the most serious outcomes of mental illnesses. TL and mtDNAcn in post-mortem samples from 528 suicide completers without severe physical illness (508 peripheral bloods; 20 brains) and 560 samples from control subjects (peripheral bloods from 535 healthy individuals; 25 post-mortem brains) were analysed by quantitative polymerase chain reaction. Suicide completers had significantly shorter TL and higher mtDNAcn of peripheral bloods with sex/age-dependent differences (shorter TL was more remarkably in female/young suicides; higher mtDNAcn more so in male/elderly suicides). The normal age-related decline of TL and mtDNAcn were significantly altered in suicide completers. Furthermore, shorter TL and lower mtDNAcn of post-mortem prefrontal cortex were seen in suicide completers compared to controls. This study shows the first association of aberrant telomeres and mtDNA content with suicide completion. Our results indicate that further research on telomere shortening and mitochondrial dysfunction may help elucidate the molecular underpinnings of suicide-related pathophysiology.
format	article
author	Ikuo Otsuka Takeshi Izumi Shuken Boku Atsushi Kimura Yuan Zhang Kentaro Mouri Satoshi Okazaki Kyoichi Shiroiwa Motonori Takahashi Yasuhiro Ueno Osamu Shirakawa Ichiro Sora Akitoyo Hishimoto
author_facet	Ikuo Otsuka Takeshi Izumi Shuken Boku Atsushi Kimura Yuan Zhang Kentaro Mouri Satoshi Okazaki Kyoichi Shiroiwa Motonori Takahashi Yasuhiro Ueno Osamu Shirakawa Ichiro Sora Akitoyo Hishimoto
author_sort	Ikuo Otsuka
title	Aberrant telomere length and mitochondrial DNA copy number in suicide completers
title_short	Aberrant telomere length and mitochondrial DNA copy number in suicide completers
title_full	Aberrant telomere length and mitochondrial DNA copy number in suicide completers
title_fullStr	Aberrant telomere length and mitochondrial DNA copy number in suicide completers
title_full_unstemmed	Aberrant telomere length and mitochondrial DNA copy number in suicide completers
title_sort	aberrant telomere length and mitochondrial dna copy number in suicide completers
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/feba59d0afea4c6b90b620a9083fb79c
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Aberrant telomere length and mitochondrial DNA copy number in suicide completers

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