Detectable A Disintegrin and Metalloproteinase With Thrombospondin Motifs-1 in Serum Is Associated With Adverse Outcome in Pediatric Sepsis
IMPORTANCE:. A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 is hypothesized to play a role in the pathogenesis of invasive infection, but studies in sepsis are lacking. OBJECTIVES:. To study A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 protein level in pediatric...
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Wolters Kluwer
2021
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oai:doaj.org-article:febca87f969b4928b470dcab2966e7892021-11-25T07:56:59ZDetectable A Disintegrin and Metalloproteinase With Thrombospondin Motifs-1 in Serum Is Associated With Adverse Outcome in Pediatric Sepsis2639-802810.1097/CCE.0000000000000569https://doaj.org/article/febca87f969b4928b470dcab2966e7892021-11-01T00:00:00Zhttp://journals.lww.com/10.1097/CCE.0000000000000569https://doaj.org/toc/2639-8028IMPORTANCE:. A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 is hypothesized to play a role in the pathogenesis of invasive infection, but studies in sepsis are lacking. OBJECTIVES:. To study A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 protein level in pediatric sepsis and to study the association with outcome. DESIGN:. Data from two prospective cohort studies. SETTING AND PARTICIPANTS:. Cohort 1 is from a single-center study involving children admitted to PICU with meningococcal sepsis (samples obtained at three time points). Cohort 2 includes patients from a multicenter study involving children admitted to the hospital with invasive bacterial infections of differing etiologies (samples obtained within 48 hr after hospital admission). MAIN OUTCOMES AND MEASURES:. Primary outcome measure was mortality. Secondary outcome measures were PICU-free days at day 28 and hospital length of stay. RESULTS:. In cohort 1 (n = 59), nonsurvivors more frequently had A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 levels above the detection limit than survivors at admission to PICU (8/11 [73%] and 6/23 [26%], respectively; p = 0.02) and at t = 24 hours (2/3 [67%] and 3/37 [8%], respectively; p = 0.04). In cohort 2 (n = 240), A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 levels in patients within 48 hours after hospital admission were more frequently above the detection limit than in healthy controls (110/240 [46%] and 14/64 [22%], respectively; p = 0.001). Nonsurvivors more often had detectable A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 levels than survivors (16/21 [76%] and 94/219 [43%], respectively; p = 0.003), which was mostly attributable to patients with Neisseria meningitidis. CONCLUSIONS AND RELEVANCE:. In children with bacterial infection, detection of A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 within 48 hours after hospital admission is associated with death, particularly in meningococcal sepsis. Future studies should confirm the prognostic value of A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 and should study pathophysiologic mechanisms.Navin P. Boeddha, MD, PhDGertjan J. Driessen, MD, PhDNienke N. Hagedoorn, MDDaniela S. Kohlfuerst, MDClive J. Hoggart, PhDAngelique L. van Rijswijk, MScEbru Ekinci, MDDebby Priem, BScLuregn J. Schlapbach, MD, PhDJethro A. Herberg, MD, PhDRonald de Groot, MD, PhDSuzanne T. Anderson, MD, PhDColin G. Fink, PhDEnitan D. Carrol, MD, PhDMichiel van der Flier, MD, PhDFederico Martinón-Torres, MD, PhDMichael Levin, MD, PhDFrank W. Leebeek, MD, PhDWerner Zenz, MD, PhDMoniek P. M. de Maat, PhDJan A. Hazelzet, MD, PhDMarieke Emonts, MD, PhDWillem A. Dik, PhDon behalf of the EUCLIDS consortiumWolters KluwerarticleMedical emergencies. Critical care. Intensive care. First aidRC86-88.9ENCritical Care Explorations, Vol 3, Iss 11, p e0569 (2021) |
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DOAJ |
| collection |
DOAJ |
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EN |
| topic |
Medical emergencies. Critical care. Intensive care. First aid RC86-88.9 |
| spellingShingle |
Medical emergencies. Critical care. Intensive care. First aid RC86-88.9 Navin P. Boeddha, MD, PhD Gertjan J. Driessen, MD, PhD Nienke N. Hagedoorn, MD Daniela S. Kohlfuerst, MD Clive J. Hoggart, PhD Angelique L. van Rijswijk, MSc Ebru Ekinci, MD Debby Priem, BSc Luregn J. Schlapbach, MD, PhD Jethro A. Herberg, MD, PhD Ronald de Groot, MD, PhD Suzanne T. Anderson, MD, PhD Colin G. Fink, PhD Enitan D. Carrol, MD, PhD Michiel van der Flier, MD, PhD Federico Martinón-Torres, MD, PhD Michael Levin, MD, PhD Frank W. Leebeek, MD, PhD Werner Zenz, MD, PhD Moniek P. M. de Maat, PhD Jan A. Hazelzet, MD, PhD Marieke Emonts, MD, PhD Willem A. Dik, PhD on behalf of the EUCLIDS consortium Detectable A Disintegrin and Metalloproteinase With Thrombospondin Motifs-1 in Serum Is Associated With Adverse Outcome in Pediatric Sepsis |
| description |
IMPORTANCE:. A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 is hypothesized to play a role in the pathogenesis of invasive infection, but studies in sepsis are lacking.
OBJECTIVES:. To study A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 protein level in pediatric sepsis and to study the association with outcome.
DESIGN:. Data from two prospective cohort studies.
SETTING AND PARTICIPANTS:. Cohort 1 is from a single-center study involving children admitted to PICU with meningococcal sepsis (samples obtained at three time points). Cohort 2 includes patients from a multicenter study involving children admitted to the hospital with invasive bacterial infections of differing etiologies (samples obtained within 48 hr after hospital admission).
MAIN OUTCOMES AND MEASURES:. Primary outcome measure was mortality. Secondary outcome measures were PICU-free days at day 28 and hospital length of stay.
RESULTS:. In cohort 1 (n = 59), nonsurvivors more frequently had A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 levels above the detection limit than survivors at admission to PICU (8/11 [73%] and 6/23 [26%], respectively; p = 0.02) and at t = 24 hours (2/3 [67%] and 3/37 [8%], respectively; p = 0.04). In cohort 2 (n = 240), A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 levels in patients within 48 hours after hospital admission were more frequently above the detection limit than in healthy controls (110/240 [46%] and 14/64 [22%], respectively; p = 0.001). Nonsurvivors more often had detectable A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 levels than survivors (16/21 [76%] and 94/219 [43%], respectively; p = 0.003), which was mostly attributable to patients with Neisseria meningitidis.
CONCLUSIONS AND RELEVANCE:. In children with bacterial infection, detection of A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 within 48 hours after hospital admission is associated with death, particularly in meningococcal sepsis. Future studies should confirm the prognostic value of A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 and should study pathophysiologic mechanisms. |
| format |
article |
| author |
Navin P. Boeddha, MD, PhD Gertjan J. Driessen, MD, PhD Nienke N. Hagedoorn, MD Daniela S. Kohlfuerst, MD Clive J. Hoggart, PhD Angelique L. van Rijswijk, MSc Ebru Ekinci, MD Debby Priem, BSc Luregn J. Schlapbach, MD, PhD Jethro A. Herberg, MD, PhD Ronald de Groot, MD, PhD Suzanne T. Anderson, MD, PhD Colin G. Fink, PhD Enitan D. Carrol, MD, PhD Michiel van der Flier, MD, PhD Federico Martinón-Torres, MD, PhD Michael Levin, MD, PhD Frank W. Leebeek, MD, PhD Werner Zenz, MD, PhD Moniek P. M. de Maat, PhD Jan A. Hazelzet, MD, PhD Marieke Emonts, MD, PhD Willem A. Dik, PhD on behalf of the EUCLIDS consortium |
| author_facet |
Navin P. Boeddha, MD, PhD Gertjan J. Driessen, MD, PhD Nienke N. Hagedoorn, MD Daniela S. Kohlfuerst, MD Clive J. Hoggart, PhD Angelique L. van Rijswijk, MSc Ebru Ekinci, MD Debby Priem, BSc Luregn J. Schlapbach, MD, PhD Jethro A. Herberg, MD, PhD Ronald de Groot, MD, PhD Suzanne T. Anderson, MD, PhD Colin G. Fink, PhD Enitan D. Carrol, MD, PhD Michiel van der Flier, MD, PhD Federico Martinón-Torres, MD, PhD Michael Levin, MD, PhD Frank W. Leebeek, MD, PhD Werner Zenz, MD, PhD Moniek P. M. de Maat, PhD Jan A. Hazelzet, MD, PhD Marieke Emonts, MD, PhD Willem A. Dik, PhD on behalf of the EUCLIDS consortium |
| author_sort |
Navin P. Boeddha, MD, PhD |
| title |
Detectable A Disintegrin and Metalloproteinase With Thrombospondin Motifs-1 in Serum Is Associated With Adverse Outcome in Pediatric Sepsis |
| title_short |
Detectable A Disintegrin and Metalloproteinase With Thrombospondin Motifs-1 in Serum Is Associated With Adverse Outcome in Pediatric Sepsis |
| title_full |
Detectable A Disintegrin and Metalloproteinase With Thrombospondin Motifs-1 in Serum Is Associated With Adverse Outcome in Pediatric Sepsis |
| title_fullStr |
Detectable A Disintegrin and Metalloproteinase With Thrombospondin Motifs-1 in Serum Is Associated With Adverse Outcome in Pediatric Sepsis |
| title_full_unstemmed |
Detectable A Disintegrin and Metalloproteinase With Thrombospondin Motifs-1 in Serum Is Associated With Adverse Outcome in Pediatric Sepsis |
| title_sort |
detectable a disintegrin and metalloproteinase with thrombospondin motifs-1 in serum is associated with adverse outcome in pediatric sepsis |
| publisher |
Wolters Kluwer |
| publishDate |
2021 |
| url |
https://doaj.org/article/febca87f969b4928b470dcab2966e789 |
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