Social isolation suppresses actin dynamics and synaptic plasticity through ADF/cofilin inactivation in the developing rat barrel cortex

Abstract Exposure to a stressful environment early in life can cause psychiatric disorders by disrupting circuit formation. Actin plays central roles in regulating neuronal structure and protein trafficking. We have recently reported that neonatal isolation inactivated ADF/cofilin, the actin depolym...

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Autores principales:	Hirobumi Tada, Tomoyuki Miyazaki, Kiwamu Takemoto, Susumu Jitsuki, Waki Nakajima, Mayu Koide, Naoko Yamamoto, Akiko Taguchi, Honami Kawai, Kasane Komiya, Kumiko Suyama, Hiroki Abe, Akane Sano, Takuya Takahashi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/febcb8090736488ca072289b8a580921
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spelling	oai:doaj.org-article:febcb8090736488ca072289b8a5809212021-12-02T15:06:24ZSocial isolation suppresses actin dynamics and synaptic plasticity through ADF/cofilin inactivation in the developing rat barrel cortex10.1038/s41598-017-08849-32045-2322https://doaj.org/article/febcb8090736488ca072289b8a5809212017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08849-3https://doaj.org/toc/2045-2322Abstract Exposure to a stressful environment early in life can cause psychiatric disorders by disrupting circuit formation. Actin plays central roles in regulating neuronal structure and protein trafficking. We have recently reported that neonatal isolation inactivated ADF/cofilin, the actin depolymerizing factor, resulted in a reduced actin dynamics at spines and an attenuation of synaptic α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor delivery in the juvenile rat medial prefrontal cortex (mPFC), leading to altered social behaviours. Here, we investigated the impact of neonatal social isolation in the developing rat barrel cortex. Similar to the mPFC study, we detected an increase in stable actin fraction in spines and this resulted in a decreased synaptic AMPA receptor delivery. Thus, we conclude that early life social isolation affects multiple cortical areas with common molecular changes.Hirobumi TadaTomoyuki MiyazakiKiwamu TakemotoSusumu JitsukiWaki NakajimaMayu KoideNaoko YamamotoAkiko TaguchiHonami KawaiKasane KomiyaKumiko SuyamaHiroki AbeAkane SanoTakuya TakahashiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hirobumi Tada Tomoyuki Miyazaki Kiwamu Takemoto Susumu Jitsuki Waki Nakajima Mayu Koide Naoko Yamamoto Akiko Taguchi Honami Kawai Kasane Komiya Kumiko Suyama Hiroki Abe Akane Sano Takuya Takahashi Social isolation suppresses actin dynamics and synaptic plasticity through ADF/cofilin inactivation in the developing rat barrel cortex
description	Abstract Exposure to a stressful environment early in life can cause psychiatric disorders by disrupting circuit formation. Actin plays central roles in regulating neuronal structure and protein trafficking. We have recently reported that neonatal isolation inactivated ADF/cofilin, the actin depolymerizing factor, resulted in a reduced actin dynamics at spines and an attenuation of synaptic α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor delivery in the juvenile rat medial prefrontal cortex (mPFC), leading to altered social behaviours. Here, we investigated the impact of neonatal social isolation in the developing rat barrel cortex. Similar to the mPFC study, we detected an increase in stable actin fraction in spines and this resulted in a decreased synaptic AMPA receptor delivery. Thus, we conclude that early life social isolation affects multiple cortical areas with common molecular changes.
format	article
author	Hirobumi Tada Tomoyuki Miyazaki Kiwamu Takemoto Susumu Jitsuki Waki Nakajima Mayu Koide Naoko Yamamoto Akiko Taguchi Honami Kawai Kasane Komiya Kumiko Suyama Hiroki Abe Akane Sano Takuya Takahashi
author_facet	Hirobumi Tada Tomoyuki Miyazaki Kiwamu Takemoto Susumu Jitsuki Waki Nakajima Mayu Koide Naoko Yamamoto Akiko Taguchi Honami Kawai Kasane Komiya Kumiko Suyama Hiroki Abe Akane Sano Takuya Takahashi
author_sort	Hirobumi Tada
title	Social isolation suppresses actin dynamics and synaptic plasticity through ADF/cofilin inactivation in the developing rat barrel cortex
title_short	Social isolation suppresses actin dynamics and synaptic plasticity through ADF/cofilin inactivation in the developing rat barrel cortex
title_full	Social isolation suppresses actin dynamics and synaptic plasticity through ADF/cofilin inactivation in the developing rat barrel cortex
title_fullStr	Social isolation suppresses actin dynamics and synaptic plasticity through ADF/cofilin inactivation in the developing rat barrel cortex
title_full_unstemmed	Social isolation suppresses actin dynamics and synaptic plasticity through ADF/cofilin inactivation in the developing rat barrel cortex
title_sort	social isolation suppresses actin dynamics and synaptic plasticity through adf/cofilin inactivation in the developing rat barrel cortex
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/febcb8090736488ca072289b8a580921
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Social isolation suppresses actin dynamics and synaptic plasticity through ADF/cofilin inactivation in the developing rat barrel cortex

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