Schizophrenia and toxoplasmosis: association with catatonic symptoms

Introduction. The association between schizophrenia and toxoplasmosis has been demonstrated in a numberof studies: the prevalence of schizophrenia is significantly higher in toxoplasmosis positive subjects than in those withT.gondii negative status. However, the clinical significance of this associa...

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Autores principales:	Dmitry V. Romanov, Aleksey Iu. Brazhnikov, Denis S. Andreyuk, N. V. Zakharova, L. V. Bravve, Vasilisa A. Kovaleva, Evgeniya V. Abbazova, Dmitriy B. Goncharov, Irina V. Titova, Elvira A. Domonova, G. P. Kostyuk
Formato:	article
Lenguaje:	EN RU
Publicado:	Eco-Vector 2020
Materias:	schizophrenia toxoplasmosis t.gondii catatonia positive and negative syndrome scale panss Psychiatry RC435-571 Psychology BF1-990
Acceso en línea:	https://doaj.org/article/fec0a9ac3b35424f98567b9fe53102c7
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spelling	oai:doaj.org-article:fec0a9ac3b35424f98567b9fe53102c72021-12-02T18:52:33ZSchizophrenia and toxoplasmosis: association with catatonic symptoms2712-76722713-291910.17650/2712-7672-2020-1-1-22-29https://doaj.org/article/fec0a9ac3b35424f98567b9fe53102c72020-08-01T00:00:00Zhttps://www.consortium-psy.com/jour/article/viewFile/29/6https://doaj.org/toc/2712-7672https://doaj.org/toc/2713-2919Introduction. The association between schizophrenia and toxoplasmosis has been demonstrated in a numberof studies: the prevalence of schizophrenia is significantly higher in toxoplasmosis positive subjects than in those withT.gondii negative status. However, the clinical significance of this association remains poorly understood. Objectives. To identify clinical phenomena that are typical for toxoplasmosis-associated (T.gondii seropositive)schizophrenia compared to Toxoplasma-seronegative schizophrenia. Methods. A retrospective database analysis of serum samples from 105 inpatients with schizophrenia (ICD-10code: F20; including 55 male patients; mean age of 27.4 6.4 years) was carried out. The clinical examinationinvolved a structured interview including ICD-10 and E. Bleulers criteria for schizophrenia and psychometric tests(Positive and Negative Scales of PANSS). Serum antibodies (IgG) to T.gondii were identified using ELISA. Thestatistical significance of any differences were evaluated using the non-parametric Mann-Whitney (U) and 2 tests. Results. The proportion of seropositive patients in the sample was 16.2%. Comparing schizophrenia patients, whowere seropositive or seronegative for toxoplasmosis, there were no statistically significant differences for the meantotal PANSS score, mean PANSS-P, PANSS-N or PANSS-G scores. For the majority of PANSS items, differences werealso statistically insignificant, except for G5 and G6mannerism and posturing. Seropositive patients had a higherscore for this item than seronegative patients: 3.5 versus 2.1 points (U=389.5; р=0.001). Depression, on the contrary,was less pronounced in seropositive than seronegative patients: 1.4 versus 2.4 points (U=509.5; р=0.023). In addition,in seropositive patients, the frequency of symptoms such as mutism according to ICD-10 criteria for schizophreniawas significantly higher (23.5% versus 3.4%, 2=9.27, р=0.013), and the whole group of catatonic symptoms accordingto the E. Bleulers criteria for schizophrenia was higher (52.9% versus 28.4%, 2=3.916, p = 0.048). Conclusion. The association between a positive toxoplasmosis status in patients with schizophrenia and catatonicsymptoms has been revealed for the first time and should be verified in larger studies.Dmitry V. RomanovAleksey Iu. BrazhnikovDenis S. AndreyukN. V. ZakharovaL. V. BravveVasilisa A. KovalevaEvgeniya V. AbbazovaDmitriy B. GoncharovIrina V. TitovaElvira A. DomonovaG. P. KostyukEco-Vectorarticleschizophreniatoxoplasmosist.gondiicatatoniapositive and negative syndrome scalepanssPsychiatryRC435-571PsychologyBF1-990ENRUConsortium Psychiatricum, Vol 1, Iss 1, Pp 22-29 (2020)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	schizophrenia toxoplasmosis t.gondii catatonia positive and negative syndrome scale panss Psychiatry RC435-571 Psychology BF1-990
spellingShingle	schizophrenia toxoplasmosis t.gondii catatonia positive and negative syndrome scale panss Psychiatry RC435-571 Psychology BF1-990 Dmitry V. Romanov Aleksey Iu. Brazhnikov Denis S. Andreyuk N. V. Zakharova L. V. Bravve Vasilisa A. Kovaleva Evgeniya V. Abbazova Dmitriy B. Goncharov Irina V. Titova Elvira A. Domonova G. P. Kostyuk Schizophrenia and toxoplasmosis: association with catatonic symptoms
description	Introduction. The association between schizophrenia and toxoplasmosis has been demonstrated in a numberof studies: the prevalence of schizophrenia is significantly higher in toxoplasmosis positive subjects than in those withT.gondii negative status. However, the clinical significance of this association remains poorly understood. Objectives. To identify clinical phenomena that are typical for toxoplasmosis-associated (T.gondii seropositive)schizophrenia compared to Toxoplasma-seronegative schizophrenia. Methods. A retrospective database analysis of serum samples from 105 inpatients with schizophrenia (ICD-10code: F20; including 55 male patients; mean age of 27.4 6.4 years) was carried out. The clinical examinationinvolved a structured interview including ICD-10 and E. Bleulers criteria for schizophrenia and psychometric tests(Positive and Negative Scales of PANSS). Serum antibodies (IgG) to T.gondii were identified using ELISA. Thestatistical significance of any differences were evaluated using the non-parametric Mann-Whitney (U) and 2 tests. Results. The proportion of seropositive patients in the sample was 16.2%. Comparing schizophrenia patients, whowere seropositive or seronegative for toxoplasmosis, there were no statistically significant differences for the meantotal PANSS score, mean PANSS-P, PANSS-N or PANSS-G scores. For the majority of PANSS items, differences werealso statistically insignificant, except for G5 and G6mannerism and posturing. Seropositive patients had a higherscore for this item than seronegative patients: 3.5 versus 2.1 points (U=389.5; р=0.001). Depression, on the contrary,was less pronounced in seropositive than seronegative patients: 1.4 versus 2.4 points (U=509.5; р=0.023). In addition,in seropositive patients, the frequency of symptoms such as mutism according to ICD-10 criteria for schizophreniawas significantly higher (23.5% versus 3.4%, 2=9.27, р=0.013), and the whole group of catatonic symptoms accordingto the E. Bleulers criteria for schizophrenia was higher (52.9% versus 28.4%, 2=3.916, p = 0.048). Conclusion. The association between a positive toxoplasmosis status in patients with schizophrenia and catatonicsymptoms has been revealed for the first time and should be verified in larger studies.
format	article
author	Dmitry V. Romanov Aleksey Iu. Brazhnikov Denis S. Andreyuk N. V. Zakharova L. V. Bravve Vasilisa A. Kovaleva Evgeniya V. Abbazova Dmitriy B. Goncharov Irina V. Titova Elvira A. Domonova G. P. Kostyuk
author_facet	Dmitry V. Romanov Aleksey Iu. Brazhnikov Denis S. Andreyuk N. V. Zakharova L. V. Bravve Vasilisa A. Kovaleva Evgeniya V. Abbazova Dmitriy B. Goncharov Irina V. Titova Elvira A. Domonova G. P. Kostyuk
author_sort	Dmitry V. Romanov
title	Schizophrenia and toxoplasmosis: association with catatonic symptoms
title_short	Schizophrenia and toxoplasmosis: association with catatonic symptoms
title_full	Schizophrenia and toxoplasmosis: association with catatonic symptoms
title_fullStr	Schizophrenia and toxoplasmosis: association with catatonic symptoms
title_full_unstemmed	Schizophrenia and toxoplasmosis: association with catatonic symptoms
title_sort	schizophrenia and toxoplasmosis: association with catatonic symptoms
publisher	Eco-Vector
publishDate	2020
url	https://doaj.org/article/fec0a9ac3b35424f98567b9fe53102c7
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Schizophrenia and toxoplasmosis: association with catatonic symptoms

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