Paracrine cellular senescence exacerbates biliary injury and impairs regeneration

Senescence has been suggested as causing biliary cholangiopathies but how this is regulated is unclear. Here, the authors generate a mouse model of biliary senescence by deleting Mdm2 in bile ducts and show that inhibiting TGFβ limits senescence-dependent aggravation of cholangiopathies.

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Autores principales:	Sofia Ferreira-Gonzalez, Wei-Yu Lu, Alexander Raven, Benjamin Dwyer, Tak Yung Man, Eoghan O’Duibhir, Philip J. Starkey Lewis, Lara Campana, Tim J. Kendall, Thomas G. Bird, Nuria Tarrats, Juan-Carlos Acosta, Luke Boulter, Stuart J. Forbes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fec37437098140028922b5a6d61c5040
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spelling	oai:doaj.org-article:fec37437098140028922b5a6d61c50402021-12-02T17:33:05ZParacrine cellular senescence exacerbates biliary injury and impairs regeneration10.1038/s41467-018-03299-52041-1723https://doaj.org/article/fec37437098140028922b5a6d61c50402018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03299-5https://doaj.org/toc/2041-1723Senescence has been suggested as causing biliary cholangiopathies but how this is regulated is unclear. Here, the authors generate a mouse model of biliary senescence by deleting Mdm2 in bile ducts and show that inhibiting TGFβ limits senescence-dependent aggravation of cholangiopathies.Sofia Ferreira-GonzalezWei-Yu LuAlexander RavenBenjamin DwyerTak Yung ManEoghan O’DuibhirPhilip J. Starkey LewisLara CampanaTim J. KendallThomas G. BirdNuria TarratsJuan-Carlos AcostaLuke BoulterStuart J. ForbesNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sofia Ferreira-Gonzalez Wei-Yu Lu Alexander Raven Benjamin Dwyer Tak Yung Man Eoghan O’Duibhir Philip J. Starkey Lewis Lara Campana Tim J. Kendall Thomas G. Bird Nuria Tarrats Juan-Carlos Acosta Luke Boulter Stuart J. Forbes Paracrine cellular senescence exacerbates biliary injury and impairs regeneration
description	Senescence has been suggested as causing biliary cholangiopathies but how this is regulated is unclear. Here, the authors generate a mouse model of biliary senescence by deleting Mdm2 in bile ducts and show that inhibiting TGFβ limits senescence-dependent aggravation of cholangiopathies.
format	article
author	Sofia Ferreira-Gonzalez Wei-Yu Lu Alexander Raven Benjamin Dwyer Tak Yung Man Eoghan O’Duibhir Philip J. Starkey Lewis Lara Campana Tim J. Kendall Thomas G. Bird Nuria Tarrats Juan-Carlos Acosta Luke Boulter Stuart J. Forbes
author_facet	Sofia Ferreira-Gonzalez Wei-Yu Lu Alexander Raven Benjamin Dwyer Tak Yung Man Eoghan O’Duibhir Philip J. Starkey Lewis Lara Campana Tim J. Kendall Thomas G. Bird Nuria Tarrats Juan-Carlos Acosta Luke Boulter Stuart J. Forbes
author_sort	Sofia Ferreira-Gonzalez
title	Paracrine cellular senescence exacerbates biliary injury and impairs regeneration
title_short	Paracrine cellular senescence exacerbates biliary injury and impairs regeneration
title_full	Paracrine cellular senescence exacerbates biliary injury and impairs regeneration
title_fullStr	Paracrine cellular senescence exacerbates biliary injury and impairs regeneration
title_full_unstemmed	Paracrine cellular senescence exacerbates biliary injury and impairs regeneration
title_sort	paracrine cellular senescence exacerbates biliary injury and impairs regeneration
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/fec37437098140028922b5a6d61c5040
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Paracrine cellular senescence exacerbates biliary injury and impairs regeneration

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