Serum uric acid and chronic kidney disease: the role of hypertension.

<h4>Background</h4>There are inconsistent findings on the role of hyperuricemia as an independent risk factor for chronic kidney disease (CKD). Hypertension has been implicated as a factor influencing the association between serum uric acid and CKD. In this population-based study we inve...

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Autores principales:	Sanaz Sedaghat, Ewout J Hoorn, Frank J A van Rooij, Albert Hofman, Oscar H Franco, Jacqueline C M Witteman, Abbas Dehghan
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fec3cc9a2f4d4488bdd902b567db76c9
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spelling	oai:doaj.org-article:fec3cc9a2f4d4488bdd902b567db76c92021-11-18T08:47:07ZSerum uric acid and chronic kidney disease: the role of hypertension.1932-620310.1371/journal.pone.0076827https://doaj.org/article/fec3cc9a2f4d4488bdd902b567db76c92013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24265674/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>There are inconsistent findings on the role of hyperuricemia as an independent risk factor for chronic kidney disease (CKD). Hypertension has been implicated as a factor influencing the association between serum uric acid and CKD. In this population-based study we investigated the association between serum uric acid and decline in renal function and tested whether hypertension moderates this association.<h4>Methods</h4>We included 2601 subjects aged 55 years and over from the Rotterdam Study. Serum uric acid and estimated glomerular filtration rate (eGFR) were assessed at baseline. After average 6.5 years of follow-up, second eGFR was assessed. CKD was defined as eGFR<60 ml/min/1.73 m(2). All associations were corrected for socio-demographic and cardiovascular factors.<h4>Results</h4>Each unit (mg/dL) increase in serum uric acid was associated with 0.19 ml/min per 1.73 m(2) faster annual decline in eGFR. While the association between serum uric acid and incidence of CKD was not significant in our study population (Hazard Ratio: 1.12, 95% confidence interval [CI]: 0.98-1.28), incorporating our results in a meta-analysis with eleven published studies revealed a significant association (Relative Risk: 1.18, 95%CI: 1.15-1.22). In the stratified analyses, we observed that the associations of serum uric acid with eGFR decline and incident CKD were stronger in hypertensive subjects (P for interaction = 0.046 and 0.024, respectively).<h4>Conclusions</h4>Our findings suggest that hyperuricemia is independently associated with a decline in renal function. Stronger association in hypertensive individuals may indicate that hypertension mediates the association between serum uric acid and CKD.Sanaz SedaghatEwout J HoornFrank J A van RooijAlbert HofmanOscar H FrancoJacqueline C M WittemanAbbas DehghanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e76827 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sanaz Sedaghat Ewout J Hoorn Frank J A van Rooij Albert Hofman Oscar H Franco Jacqueline C M Witteman Abbas Dehghan Serum uric acid and chronic kidney disease: the role of hypertension.
description	<h4>Background</h4>There are inconsistent findings on the role of hyperuricemia as an independent risk factor for chronic kidney disease (CKD). Hypertension has been implicated as a factor influencing the association between serum uric acid and CKD. In this population-based study we investigated the association between serum uric acid and decline in renal function and tested whether hypertension moderates this association.<h4>Methods</h4>We included 2601 subjects aged 55 years and over from the Rotterdam Study. Serum uric acid and estimated glomerular filtration rate (eGFR) were assessed at baseline. After average 6.5 years of follow-up, second eGFR was assessed. CKD was defined as eGFR<60 ml/min/1.73 m(2). All associations were corrected for socio-demographic and cardiovascular factors.<h4>Results</h4>Each unit (mg/dL) increase in serum uric acid was associated with 0.19 ml/min per 1.73 m(2) faster annual decline in eGFR. While the association between serum uric acid and incidence of CKD was not significant in our study population (Hazard Ratio: 1.12, 95% confidence interval [CI]: 0.98-1.28), incorporating our results in a meta-analysis with eleven published studies revealed a significant association (Relative Risk: 1.18, 95%CI: 1.15-1.22). In the stratified analyses, we observed that the associations of serum uric acid with eGFR decline and incident CKD were stronger in hypertensive subjects (P for interaction = 0.046 and 0.024, respectively).<h4>Conclusions</h4>Our findings suggest that hyperuricemia is independently associated with a decline in renal function. Stronger association in hypertensive individuals may indicate that hypertension mediates the association between serum uric acid and CKD.
format	article
author	Sanaz Sedaghat Ewout J Hoorn Frank J A van Rooij Albert Hofman Oscar H Franco Jacqueline C M Witteman Abbas Dehghan
author_facet	Sanaz Sedaghat Ewout J Hoorn Frank J A van Rooij Albert Hofman Oscar H Franco Jacqueline C M Witteman Abbas Dehghan
author_sort	Sanaz Sedaghat
title	Serum uric acid and chronic kidney disease: the role of hypertension.
title_short	Serum uric acid and chronic kidney disease: the role of hypertension.
title_full	Serum uric acid and chronic kidney disease: the role of hypertension.
title_fullStr	Serum uric acid and chronic kidney disease: the role of hypertension.
title_full_unstemmed	Serum uric acid and chronic kidney disease: the role of hypertension.
title_sort	serum uric acid and chronic kidney disease: the role of hypertension.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/fec3cc9a2f4d4488bdd902b567db76c9
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Serum uric acid and chronic kidney disease: the role of hypertension.

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