Ultra-widefield fluorescein angiography of white without pressure

Anton Orlin, Aalya Fatoo, Joshua Ehrlich, Donald J D'Amico, RV Paul Chan, Szilárd KissDepartment of Ophthalmology, Weill Cornell Medical College, New York, NY, USAPurpose: To describe ultra-widefield fluorescein angiography (UWFA) findings in eyes with white without pressure (WWOP...

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Autores principales:	Orlin A, Fatoo A, Ehrlich J, D&#39;Amico DJ, Chan RVP, Kiss S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/fec3e7b417034e2981eaad49abbdb8e8
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spelling	oai:doaj.org-article:fec3e7b417034e2981eaad49abbdb8e82021-12-02T01:28:56ZUltra-widefield fluorescein angiography of white without pressure1177-54671177-5483https://doaj.org/article/fec3e7b417034e2981eaad49abbdb8e82013-05-01T00:00:00Zhttp://www.dovepress.com/ultra-widefield-fluorescein-angiography-of-white-without-pressure-a13144https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Anton Orlin, Aalya Fatoo, Joshua Ehrlich, Donald J D'Amico, RV Paul Chan, Szilárd KissDepartment of Ophthalmology, Weill Cornell Medical College, New York, NY, USAPurpose: To describe ultra-widefield fluorescein angiography (UWFA) findings in eyes with white without pressure (WWOP) and in eyes without any obvious peripheral chorioretinal disease, and to determine if a difference exists between these two groups.Methods: A retrospective review of 379 eyes undergoing diagnostic UWFA using the Optos 200Tx imaging system. Eyes were excluded if the quality of the color photograph or UWFA prevented reliable evaluation. Eyes were also excluded if there was any evidence of peripheral retinal or choroidal disease, which was thought to have an effect on UWFA (eg, peripheral background diabetic or hypertensive retinopathy, vein occlusion, or any other peripheral vascular disorder). Eyes were determined to have WWOP, based on a dilated fundus examination and color fundus photography that contained areas of peripheral retinal whitening consistent with the diagnosis. UWFA was evaluated by trained masked graders, and determined to have or not have peripheral vascular leakage and/or staining.Results: Of the 379 eyes evaluated, 45 eyes were included in the study. Twelve eyes were determined to have peripheral WWOP; 33 eyes did not have WWOP on examination or color fundus photography. Three common UWFA peripheral patterns were visualized. Eyes with and without WWOP were grouped into one of three patterns. The majority of eyes without WWOP demonstrated UWFA pattern one (69.7%), while those in the WWOP group demonstrated pattern three (50%). The distribution of UWFA patterns is statistically different between those with and without WWOP (P = 0.002). In eyes without WWOP, in patients with no documented systemic microvascular disease (diabetes, hypertension), 71.4% of eyes had UWFA pattern one while 14.3% had both patterns two and three.Conclusion: This study is one of the first to specifically evaluate peripheral vascular leakage/staining in eyes with WWOP as well as in eyes without any obvious peripheral chorioretinal disease. We demonstrate that a significant portion of WWOP eyes exhibit peripheral findings on UWFA (pattern one) compared to eyes without WWOP. Importantly, even in eyes that are apparently unremarkable in the periphery on exam and color photography, UWFA can still show peripheral vascular abnormalities. These results warrant further investigation.Keywords: ocular imaging, ptos imaging, retina peripheryOrlin AFatoo AEhrlich JD&#39;Amico DJChan RVPKiss SDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 959-964 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Orlin A Fatoo A Ehrlich J D&#39;Amico DJ Chan RVP Kiss S Ultra-widefield fluorescein angiography of white without pressure
description	Anton Orlin, Aalya Fatoo, Joshua Ehrlich, Donald J D'Amico, RV Paul Chan, Szilárd KissDepartment of Ophthalmology, Weill Cornell Medical College, New York, NY, USAPurpose: To describe ultra-widefield fluorescein angiography (UWFA) findings in eyes with white without pressure (WWOP) and in eyes without any obvious peripheral chorioretinal disease, and to determine if a difference exists between these two groups.Methods: A retrospective review of 379 eyes undergoing diagnostic UWFA using the Optos 200Tx imaging system. Eyes were excluded if the quality of the color photograph or UWFA prevented reliable evaluation. Eyes were also excluded if there was any evidence of peripheral retinal or choroidal disease, which was thought to have an effect on UWFA (eg, peripheral background diabetic or hypertensive retinopathy, vein occlusion, or any other peripheral vascular disorder). Eyes were determined to have WWOP, based on a dilated fundus examination and color fundus photography that contained areas of peripheral retinal whitening consistent with the diagnosis. UWFA was evaluated by trained masked graders, and determined to have or not have peripheral vascular leakage and/or staining.Results: Of the 379 eyes evaluated, 45 eyes were included in the study. Twelve eyes were determined to have peripheral WWOP; 33 eyes did not have WWOP on examination or color fundus photography. Three common UWFA peripheral patterns were visualized. Eyes with and without WWOP were grouped into one of three patterns. The majority of eyes without WWOP demonstrated UWFA pattern one (69.7%), while those in the WWOP group demonstrated pattern three (50%). The distribution of UWFA patterns is statistically different between those with and without WWOP (P = 0.002). In eyes without WWOP, in patients with no documented systemic microvascular disease (diabetes, hypertension), 71.4% of eyes had UWFA pattern one while 14.3% had both patterns two and three.Conclusion: This study is one of the first to specifically evaluate peripheral vascular leakage/staining in eyes with WWOP as well as in eyes without any obvious peripheral chorioretinal disease. We demonstrate that a significant portion of WWOP eyes exhibit peripheral findings on UWFA (pattern one) compared to eyes without WWOP. Importantly, even in eyes that are apparently unremarkable in the periphery on exam and color photography, UWFA can still show peripheral vascular abnormalities. These results warrant further investigation.Keywords: ocular imaging, ptos imaging, retina periphery
format	article
author	Orlin A Fatoo A Ehrlich J D&#39;Amico DJ Chan RVP Kiss S
author_facet	Orlin A Fatoo A Ehrlich J D&#39;Amico DJ Chan RVP Kiss S
author_sort	Orlin A
title	Ultra-widefield fluorescein angiography of white without pressure
title_short	Ultra-widefield fluorescein angiography of white without pressure
title_full	Ultra-widefield fluorescein angiography of white without pressure
title_fullStr	Ultra-widefield fluorescein angiography of white without pressure
title_full_unstemmed	Ultra-widefield fluorescein angiography of white without pressure
title_sort	ultra-widefield fluorescein angiography of white without pressure
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/fec3e7b417034e2981eaad49abbdb8e8
work_keys_str_mv	AT orlina ultrawidefieldfluoresceinangiographyofwhitewithoutpressure AT fatooa ultrawidefieldfluoresceinangiographyofwhitewithoutpressure AT ehrlichj ultrawidefieldfluoresceinangiographyofwhitewithoutpressure AT damp39amicodj ultrawidefieldfluoresceinangiographyofwhitewithoutpressure AT chanrvp ultrawidefieldfluoresceinangiographyofwhitewithoutpressure AT kisss ultrawidefieldfluoresceinangiographyofwhitewithoutpressure
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Ultra-widefield fluorescein angiography of white without pressure

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