Factors associated with the high medication regimen complexity index in pediatric patients with chronic renal disease

Objective: To determine the factors associated with the high medication regimen complexity in pediatric patients with chronic kidney disease. Methods: An observational, cross-sectional, descriptive and analytical study was conducted with patients treated at a multiprofessional outpatient clinic of...

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Autores principales:	Amanda M. PAIVA, Lívia P. SILVEIRA, Ronara C. GROIA-VELOSO, Isabela B. RAGGI, Máyra R. FERNANDES, Patrícia G. ARAÚJO, Maria D. SILVA, Clarice CHEMELLO
Formato:	article
Lenguaje:	EN PT
Publicado:	Sociedade Brasileira de Farmácia Hospitalar e Serviços de Saúde 2020
Materias:	Public aspects of medicine RA1-1270 Pharmacy and materia medica RS1-441 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/fec79ea3abce48898549cee8a30cdb3c
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spelling	oai:doaj.org-article:fec79ea3abce48898549cee8a30cdb3c2021-11-28T02:44:08ZFactors associated with the high medication regimen complexity index in pediatric patients with chronic renal disease10.30968/rbfhss.2020.114.05112179-59242316-7750https://doaj.org/article/fec79ea3abce48898549cee8a30cdb3c2020-12-01T00:00:00Zhttps://www.rbfhss.org.br/sbrafh/article/view/511https://doaj.org/toc/2179-5924https://doaj.org/toc/2316-7750 Objective: To determine the factors associated with the high medication regimen complexity in pediatric patients with chronic kidney disease. Methods: An observational, cross-sectional, descriptive and analytical study was conducted with patients treated at a multiprofessional outpatient clinic of a public teaching hospital. Data were collected from July to September 2019 from the medical record and pharmacotherapeutic follow-up form. The medication regimen complexity was the dependent variable and was assessed by the Medication Regimen Complexity Index. The independent variables were sex, age, number of diseases, number of medications, adherence to treatment and access to health services. The complexity was considered high when the the Medication Regimen Complexity Index was greater than 13.5 points. The association between the occurrence of high complexity of pharmacotherapy and the independent variables was performed using Pearson’s chi-square test and Fisher’s exact test. For univariate and multivariate analysis, the magnitude of the association was expressed by the odds ratio with a 95% confidence interval. Results: All patients treated during the study period were included in the study (n = 31). 67.7% of patients (n = 21) used at least four drugs, the same percentage presented complexity of high pharmacotherapy, being associated with the number of drugs used (p <0.001). The class of drugs, plus drugs that do not act on the cardiovascular system, 30% (n = 30). The most used medication by patients was sodium bicarbonate (n = 22; 70%). Conclusions: The high medication regimen complexity was associated with the number of drugs used and was observed in most patients studied, highlighting the importance of assessing the ICFT in children to optimize pharmacotherapy and, consequently, pediatric patient safety. Amanda M. PAIVALívia P. SILVEIRARonara C. GROIA-VELOSOIsabela B. RAGGIMáyra R. FERNANDESPatrícia G. ARAÚJOMaria D. SILVAClarice CHEMELLOSociedade Brasileira de Farmácia Hospitalar e Serviços de SaúdearticlePublic aspects of medicineRA1-1270Pharmacy and materia medicaRS1-441Therapeutics. PharmacologyRM1-950ENPTRevista Brasileira de Farmácia Hospitalar e Serviços de Saúde, Vol 11, Iss 4 (2020)
institution	DOAJ
collection	DOAJ
language	EN PT
topic	Public aspects of medicine RA1-1270 Pharmacy and materia medica RS1-441 Therapeutics. Pharmacology RM1-950
spellingShingle	Public aspects of medicine RA1-1270 Pharmacy and materia medica RS1-441 Therapeutics. Pharmacology RM1-950 Amanda M. PAIVA Lívia P. SILVEIRA Ronara C. GROIA-VELOSO Isabela B. RAGGI Máyra R. FERNANDES Patrícia G. ARAÚJO Maria D. SILVA Clarice CHEMELLO Factors associated with the high medication regimen complexity index in pediatric patients with chronic renal disease
description	Objective: To determine the factors associated with the high medication regimen complexity in pediatric patients with chronic kidney disease. Methods: An observational, cross-sectional, descriptive and analytical study was conducted with patients treated at a multiprofessional outpatient clinic of a public teaching hospital. Data were collected from July to September 2019 from the medical record and pharmacotherapeutic follow-up form. The medication regimen complexity was the dependent variable and was assessed by the Medication Regimen Complexity Index. The independent variables were sex, age, number of diseases, number of medications, adherence to treatment and access to health services. The complexity was considered high when the the Medication Regimen Complexity Index was greater than 13.5 points. The association between the occurrence of high complexity of pharmacotherapy and the independent variables was performed using Pearson’s chi-square test and Fisher’s exact test. For univariate and multivariate analysis, the magnitude of the association was expressed by the odds ratio with a 95% confidence interval. Results: All patients treated during the study period were included in the study (n = 31). 67.7% of patients (n = 21) used at least four drugs, the same percentage presented complexity of high pharmacotherapy, being associated with the number of drugs used (p <0.001). The class of drugs, plus drugs that do not act on the cardiovascular system, 30% (n = 30). The most used medication by patients was sodium bicarbonate (n = 22; 70%). Conclusions: The high medication regimen complexity was associated with the number of drugs used and was observed in most patients studied, highlighting the importance of assessing the ICFT in children to optimize pharmacotherapy and, consequently, pediatric patient safety.
format	article
author	Amanda M. PAIVA Lívia P. SILVEIRA Ronara C. GROIA-VELOSO Isabela B. RAGGI Máyra R. FERNANDES Patrícia G. ARAÚJO Maria D. SILVA Clarice CHEMELLO
author_facet	Amanda M. PAIVA Lívia P. SILVEIRA Ronara C. GROIA-VELOSO Isabela B. RAGGI Máyra R. FERNANDES Patrícia G. ARAÚJO Maria D. SILVA Clarice CHEMELLO
author_sort	Amanda M. PAIVA
title	Factors associated with the high medication regimen complexity index in pediatric patients with chronic renal disease
title_short	Factors associated with the high medication regimen complexity index in pediatric patients with chronic renal disease
title_full	Factors associated with the high medication regimen complexity index in pediatric patients with chronic renal disease
title_fullStr	Factors associated with the high medication regimen complexity index in pediatric patients with chronic renal disease
title_full_unstemmed	Factors associated with the high medication regimen complexity index in pediatric patients with chronic renal disease
title_sort	factors associated with the high medication regimen complexity index in pediatric patients with chronic renal disease
publisher	Sociedade Brasileira de Farmácia Hospitalar e Serviços de Saúde
publishDate	2020
url	https://doaj.org/article/fec79ea3abce48898549cee8a30cdb3c
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Factors associated with the high medication regimen complexity index in pediatric patients with chronic renal disease

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