Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation

How reproducible human kidney organoids derived from different iPSC lines are, and how faithful they are to human kidney tissue remain unclear. Here, the authors use four human iPSC lines to derive kidney organoids and show how organoid composition is reproducible, comparable to human tissue and of...

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Autores principales:	Ayshwarya Subramanian, Eriene-Heidi Sidhom, Maheswarareddy Emani, Katherine Vernon, Nareh Sahakian, Yiming Zhou, Maria Kost-Alimova, Michal Slyper, Julia Waldman, Danielle Dionne, Lan T. Nguyen, Astrid Weins, Jamie L. Marshall, Orit Rosenblatt-Rosen, Aviv Regev, Anna Greka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fec9d1d79cc3436c8e6951c9b267d13d
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spelling	oai:doaj.org-article:fec9d1d79cc3436c8e6951c9b267d13d2021-12-02T15:35:10ZSingle cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation10.1038/s41467-019-13382-02041-1723https://doaj.org/article/fec9d1d79cc3436c8e6951c9b267d13d2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13382-0https://doaj.org/toc/2041-1723How reproducible human kidney organoids derived from different iPSC lines are, and how faithful they are to human kidney tissue remain unclear. Here, the authors use four human iPSC lines to derive kidney organoids and show how organoid composition is reproducible, comparable to human tissue and of improved quality after transplantation.Ayshwarya SubramanianEriene-Heidi SidhomMaheswarareddy EmaniKatherine VernonNareh SahakianYiming ZhouMaria Kost-AlimovaMichal SlyperJulia WaldmanDanielle DionneLan T. NguyenAstrid WeinsJamie L. MarshallOrit Rosenblatt-RosenAviv RegevAnna GrekaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ayshwarya Subramanian Eriene-Heidi Sidhom Maheswarareddy Emani Katherine Vernon Nareh Sahakian Yiming Zhou Maria Kost-Alimova Michal Slyper Julia Waldman Danielle Dionne Lan T. Nguyen Astrid Weins Jamie L. Marshall Orit Rosenblatt-Rosen Aviv Regev Anna Greka Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation
description	How reproducible human kidney organoids derived from different iPSC lines are, and how faithful they are to human kidney tissue remain unclear. Here, the authors use four human iPSC lines to derive kidney organoids and show how organoid composition is reproducible, comparable to human tissue and of improved quality after transplantation.
format	article
author	Ayshwarya Subramanian Eriene-Heidi Sidhom Maheswarareddy Emani Katherine Vernon Nareh Sahakian Yiming Zhou Maria Kost-Alimova Michal Slyper Julia Waldman Danielle Dionne Lan T. Nguyen Astrid Weins Jamie L. Marshall Orit Rosenblatt-Rosen Aviv Regev Anna Greka
author_facet	Ayshwarya Subramanian Eriene-Heidi Sidhom Maheswarareddy Emani Katherine Vernon Nareh Sahakian Yiming Zhou Maria Kost-Alimova Michal Slyper Julia Waldman Danielle Dionne Lan T. Nguyen Astrid Weins Jamie L. Marshall Orit Rosenblatt-Rosen Aviv Regev Anna Greka
author_sort	Ayshwarya Subramanian
title	Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation
title_short	Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation
title_full	Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation
title_fullStr	Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation
title_full_unstemmed	Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation
title_sort	single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/fec9d1d79cc3436c8e6951c9b267d13d
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Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation

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