Force-clamp spectroscopy identifies a catch bond mechanism in a Gram-positive pathogen
During colonization of host tissues and biomaterials, staphylococci are exposed to extreme mechanical forces. Here authors use force-clamp spectroscopy and show that the dock, lock and latch interaction between staphylococcal surface protein SpsD and fibrinogen is extremely strong, and exhibits an u...
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| Autores principales: | , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2020
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/feca3bc0c89c4e12a02e7b8246148655 |
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| Sumario: | During colonization of host tissues and biomaterials, staphylococci are exposed to extreme mechanical forces. Here authors use force-clamp spectroscopy and show that the dock, lock and latch interaction between staphylococcal surface protein SpsD and fibrinogen is extremely strong, and exhibits an unusual catch-slip transition. |
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