Force-clamp spectroscopy identifies a catch bond mechanism in a Gram-positive pathogen

During colonization of host tissues and biomaterials, staphylococci are exposed to extreme mechanical forces. Here authors use force-clamp spectroscopy and show that the dock, lock and latch interaction between staphylococcal surface protein SpsD and fibrinogen is extremely strong, and exhibits an u...

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Autores principales:	Marion Mathelié-Guinlet, Felipe Viela, Giampiero Pietrocola, Pietro Speziale, David Alsteens, Yves F. Dufrêne
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/feca3bc0c89c4e12a02e7b8246148655
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spelling	oai:doaj.org-article:feca3bc0c89c4e12a02e7b82461486552021-12-02T17:31:57ZForce-clamp spectroscopy identifies a catch bond mechanism in a Gram-positive pathogen10.1038/s41467-020-19216-82041-1723https://doaj.org/article/feca3bc0c89c4e12a02e7b82461486552020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19216-8https://doaj.org/toc/2041-1723During colonization of host tissues and biomaterials, staphylococci are exposed to extreme mechanical forces. Here authors use force-clamp spectroscopy and show that the dock, lock and latch interaction between staphylococcal surface protein SpsD and fibrinogen is extremely strong, and exhibits an unusual catch-slip transition.Marion Mathelié-GuinletFelipe VielaGiampiero PietrocolaPietro SpezialeDavid AlsteensYves F. DufrêneNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marion Mathelié-Guinlet Felipe Viela Giampiero Pietrocola Pietro Speziale David Alsteens Yves F. Dufrêne Force-clamp spectroscopy identifies a catch bond mechanism in a Gram-positive pathogen
description	During colonization of host tissues and biomaterials, staphylococci are exposed to extreme mechanical forces. Here authors use force-clamp spectroscopy and show that the dock, lock and latch interaction between staphylococcal surface protein SpsD and fibrinogen is extremely strong, and exhibits an unusual catch-slip transition.
format	article
author	Marion Mathelié-Guinlet Felipe Viela Giampiero Pietrocola Pietro Speziale David Alsteens Yves F. Dufrêne
author_facet	Marion Mathelié-Guinlet Felipe Viela Giampiero Pietrocola Pietro Speziale David Alsteens Yves F. Dufrêne
author_sort	Marion Mathelié-Guinlet
title	Force-clamp spectroscopy identifies a catch bond mechanism in a Gram-positive pathogen
title_short	Force-clamp spectroscopy identifies a catch bond mechanism in a Gram-positive pathogen
title_full	Force-clamp spectroscopy identifies a catch bond mechanism in a Gram-positive pathogen
title_fullStr	Force-clamp spectroscopy identifies a catch bond mechanism in a Gram-positive pathogen
title_full_unstemmed	Force-clamp spectroscopy identifies a catch bond mechanism in a Gram-positive pathogen
title_sort	force-clamp spectroscopy identifies a catch bond mechanism in a gram-positive pathogen
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/feca3bc0c89c4e12a02e7b8246148655
work_keys_str_mv	AT marionmathelieguinlet forceclampspectroscopyidentifiesacatchbondmechanisminagrampositivepathogen AT felipeviela forceclampspectroscopyidentifiesacatchbondmechanisminagrampositivepathogen AT giampieropietrocola forceclampspectroscopyidentifiesacatchbondmechanisminagrampositivepathogen AT pietrospeziale forceclampspectroscopyidentifiesacatchbondmechanisminagrampositivepathogen AT davidalsteens forceclampspectroscopyidentifiesacatchbondmechanisminagrampositivepathogen AT yvesfdufrene forceclampspectroscopyidentifiesacatchbondmechanisminagrampositivepathogen
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Force-clamp spectroscopy identifies a catch bond mechanism in a Gram-positive pathogen

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