Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3’ regulatory region

The IgH3’ regulatory region contains an evolutionarily conserved palindromic sequence flanking important enhancer elements. Here the authors show that the palindrome is required for generating antibody diversity.

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Autores principales:	Alexis Saintamand, Christelle Vincent-Fabert, Armand Garot, Pauline Rouaud, Zeliha Oruc, Virginie Magnone, Michel Cogné, Yves Denizot
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fecbd343ebf14565a1611923292c4611
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spelling	oai:doaj.org-article:fecbd343ebf14565a1611923292c46112021-12-02T17:33:20ZDeciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3’ regulatory region10.1038/ncomms107302041-1723https://doaj.org/article/fecbd343ebf14565a1611923292c46112016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10730https://doaj.org/toc/2041-1723The IgH3’ regulatory region contains an evolutionarily conserved palindromic sequence flanking important enhancer elements. Here the authors show that the palindrome is required for generating antibody diversity.Alexis SaintamandChristelle Vincent-FabertArmand GarotPauline RouaudZeliha OrucVirginie MagnoneMichel CognéYves DenizotNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexis Saintamand Christelle Vincent-Fabert Armand Garot Pauline Rouaud Zeliha Oruc Virginie Magnone Michel Cogné Yves Denizot Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3’ regulatory region
description	The IgH3’ regulatory region contains an evolutionarily conserved palindromic sequence flanking important enhancer elements. Here the authors show that the palindrome is required for generating antibody diversity.
format	article
author	Alexis Saintamand Christelle Vincent-Fabert Armand Garot Pauline Rouaud Zeliha Oruc Virginie Magnone Michel Cogné Yves Denizot
author_facet	Alexis Saintamand Christelle Vincent-Fabert Armand Garot Pauline Rouaud Zeliha Oruc Virginie Magnone Michel Cogné Yves Denizot
author_sort	Alexis Saintamand
title	Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3’ regulatory region
title_short	Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3’ regulatory region
title_full	Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3’ regulatory region
title_fullStr	Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3’ regulatory region
title_full_unstemmed	Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3’ regulatory region
title_sort	deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3’ regulatory region
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/fecbd343ebf14565a1611923292c4611
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Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3’ regulatory region

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