Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3’ regulatory region

Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3’ regulatory region

The IgH3’ regulatory region contains an evolutionarily conserved palindromic sequence flanking important enhancer elements. Here the authors show that the palindrome is required for generating antibody diversity.

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Detalles Bibliográficos
Autores principales: Alexis Saintamand, Christelle Vincent-Fabert, Armand Garot, Pauline Rouaud, Zeliha Oruc, Virginie Magnone, Michel Cogné, Yves Denizot
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
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Acceso en línea:https://doaj.org/article/fecbd343ebf14565a1611923292c4611
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