Animal models of frailty: current applications in clinical research

Alice E Kane,1 Sarah N Hilmer,2–4 John Mach,2–4 Sarah J Mitchell,5 Rafael de Cabo,5 Susan E Howlett1 1Department of Pharmacology, Dalhousie University, Halifax, NS, Canada; 2Kolling Institute of Medical Research and Sydney Medical School, University of Sydney, 3Department of Cli...

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Autores principales:	Kane AE, Hilmer SN, Mach J, Mitchell SJ, de Cabo R, Howlett SE
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Mouse Models Frailty Index Frailty Phenotype IL-10 knock-out Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/fecc6d14458b4e42ace086040a41627d
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spelling	oai:doaj.org-article:fecc6d14458b4e42ace086040a41627d2021-12-02T06:01:00ZAnimal models of frailty: current applications in clinical research1178-1998https://doaj.org/article/fecc6d14458b4e42ace086040a41627d2016-10-01T00:00:00Zhttps://www.dovepress.com/animal-models-of-frailty-current-applications-in-clinical-research-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Alice E Kane,1 Sarah N Hilmer,2–4 John Mach,2–4 Sarah J Mitchell,5 Rafael de Cabo,5 Susan E Howlett1 1Department of Pharmacology, Dalhousie University, Halifax, NS, Canada; 2Kolling Institute of Medical Research and Sydney Medical School, University of Sydney, 3Department of Clinical Pharmacology, 4Department of Aged Care, Royal North Shore Hospital, Sydney, NSW, Australia; 5National Institute on Aging, National Institutes of Health, Baltimore, MD, USA Abstract: The ethical, logistical, and biological complications of working with an older population of people inherently limits clinical studies of frailty. The recent development of animal models of frailty, and tools for assessing frailty in animal models provides an invaluable opportunity for frailty research. This review summarizes currently published animal models of frailty including the interleukin-10 knock-out mouse, the mouse frailty phenotype assessment tool, and the mouse clinical frailty index. It discusses both current and potential roles of these models in research into mechanisms of frailty, interventions to prevent/delay frailty, and the effect of frailty on outcomes. Finally, this review discusses some of the challenges and opportunities of translating research findings from animals to humans. Keywords: mouse models, frailty index, frailty phenotype, IL-10 knock-outKane AEHilmer SNMach JMitchell SJde Cabo RHowlett SEDove Medical PressarticleMouse ModelsFrailty IndexFrailty PhenotypeIL-10 knock-outGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 11, Pp 1519-1529 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Mouse Models Frailty Index Frailty Phenotype IL-10 knock-out Geriatrics RC952-954.6
spellingShingle	Mouse Models Frailty Index Frailty Phenotype IL-10 knock-out Geriatrics RC952-954.6 Kane AE Hilmer SN Mach J Mitchell SJ de Cabo R Howlett SE Animal models of frailty: current applications in clinical research
description	Alice E Kane,1 Sarah N Hilmer,2–4 John Mach,2–4 Sarah J Mitchell,5 Rafael de Cabo,5 Susan E Howlett1 1Department of Pharmacology, Dalhousie University, Halifax, NS, Canada; 2Kolling Institute of Medical Research and Sydney Medical School, University of Sydney, 3Department of Clinical Pharmacology, 4Department of Aged Care, Royal North Shore Hospital, Sydney, NSW, Australia; 5National Institute on Aging, National Institutes of Health, Baltimore, MD, USA Abstract: The ethical, logistical, and biological complications of working with an older population of people inherently limits clinical studies of frailty. The recent development of animal models of frailty, and tools for assessing frailty in animal models provides an invaluable opportunity for frailty research. This review summarizes currently published animal models of frailty including the interleukin-10 knock-out mouse, the mouse frailty phenotype assessment tool, and the mouse clinical frailty index. It discusses both current and potential roles of these models in research into mechanisms of frailty, interventions to prevent/delay frailty, and the effect of frailty on outcomes. Finally, this review discusses some of the challenges and opportunities of translating research findings from animals to humans. Keywords: mouse models, frailty index, frailty phenotype, IL-10 knock-out
format	article
author	Kane AE Hilmer SN Mach J Mitchell SJ de Cabo R Howlett SE
author_facet	Kane AE Hilmer SN Mach J Mitchell SJ de Cabo R Howlett SE
author_sort	Kane AE
title	Animal models of frailty: current applications in clinical research
title_short	Animal models of frailty: current applications in clinical research
title_full	Animal models of frailty: current applications in clinical research
title_fullStr	Animal models of frailty: current applications in clinical research
title_full_unstemmed	Animal models of frailty: current applications in clinical research
title_sort	animal models of frailty: current applications in clinical research
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/fecc6d14458b4e42ace086040a41627d
work_keys_str_mv	AT kaneae animalmodelsoffrailtycurrentapplicationsinclinicalresearch AT hilmersn animalmodelsoffrailtycurrentapplicationsinclinicalresearch AT machj animalmodelsoffrailtycurrentapplicationsinclinicalresearch AT mitchellsj animalmodelsoffrailtycurrentapplicationsinclinicalresearch AT decabor animalmodelsoffrailtycurrentapplicationsinclinicalresearch AT howlettse animalmodelsoffrailtycurrentapplicationsinclinicalresearch
_version_	1718400151074111488

Animal models of frailty: current applications in clinical research

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