Hakai is required for stabilization of core components of the m6A mRNA methylation machinery

The E3 ligase Hakai can interact with the m6A methylation machinery but its function is still unclear. Here, the authors show that Hakai is a conserved component of the m6A methyltransferase complex and provide functional and molecular insights into its role in regulating m6A levels in Drosophila.

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Autores principales:	Praveen Bawankar, Tina Lence, Chiara Paolantoni, Irmgard U. Haussmann, Migle Kazlauskiene, Dominik Jacob, Jan B. Heidelberger, Florian M. Richter, Mohanakarthik P. Nallasivan, Violeta Morin, Nastasja Kreim, Petra Beli, Mark Helm, Martin Jinek, Matthias Soller, Jean-Yves Roignant
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fecec708c84b4bd4904def2c94ce32a6
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spelling	oai:doaj.org-article:fecec708c84b4bd4904def2c94ce32a62021-12-02T17:24:08ZHakai is required for stabilization of core components of the m6A mRNA methylation machinery10.1038/s41467-021-23892-52041-1723https://doaj.org/article/fecec708c84b4bd4904def2c94ce32a62021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23892-5https://doaj.org/toc/2041-1723The E3 ligase Hakai can interact with the m6A methylation machinery but its function is still unclear. Here, the authors show that Hakai is a conserved component of the m6A methyltransferase complex and provide functional and molecular insights into its role in regulating m6A levels in Drosophila.Praveen BawankarTina LenceChiara PaolantoniIrmgard U. HaussmannMigle KazlauskieneDominik JacobJan B. HeidelbergerFlorian M. RichterMohanakarthik P. NallasivanVioleta MorinNastasja KreimPetra BeliMark HelmMartin JinekMatthias SollerJean-Yves RoignantNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Praveen Bawankar Tina Lence Chiara Paolantoni Irmgard U. Haussmann Migle Kazlauskiene Dominik Jacob Jan B. Heidelberger Florian M. Richter Mohanakarthik P. Nallasivan Violeta Morin Nastasja Kreim Petra Beli Mark Helm Martin Jinek Matthias Soller Jean-Yves Roignant Hakai is required for stabilization of core components of the m6A mRNA methylation machinery
description	The E3 ligase Hakai can interact with the m6A methylation machinery but its function is still unclear. Here, the authors show that Hakai is a conserved component of the m6A methyltransferase complex and provide functional and molecular insights into its role in regulating m6A levels in Drosophila.
format	article
author	Praveen Bawankar Tina Lence Chiara Paolantoni Irmgard U. Haussmann Migle Kazlauskiene Dominik Jacob Jan B. Heidelberger Florian M. Richter Mohanakarthik P. Nallasivan Violeta Morin Nastasja Kreim Petra Beli Mark Helm Martin Jinek Matthias Soller Jean-Yves Roignant
author_facet	Praveen Bawankar Tina Lence Chiara Paolantoni Irmgard U. Haussmann Migle Kazlauskiene Dominik Jacob Jan B. Heidelberger Florian M. Richter Mohanakarthik P. Nallasivan Violeta Morin Nastasja Kreim Petra Beli Mark Helm Martin Jinek Matthias Soller Jean-Yves Roignant
author_sort	Praveen Bawankar
title	Hakai is required for stabilization of core components of the m6A mRNA methylation machinery
title_short	Hakai is required for stabilization of core components of the m6A mRNA methylation machinery
title_full	Hakai is required for stabilization of core components of the m6A mRNA methylation machinery
title_fullStr	Hakai is required for stabilization of core components of the m6A mRNA methylation machinery
title_full_unstemmed	Hakai is required for stabilization of core components of the m6A mRNA methylation machinery
title_sort	hakai is required for stabilization of core components of the m6a mrna methylation machinery
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fecec708c84b4bd4904def2c94ce32a6
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Hakai is required for stabilization of core components of the m6A mRNA methylation machinery

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