Short-Term Efficacy and Safety of Switching from a Latanoprost/Timolol Fixed Combination to a Latanoprost/Carteolol Fixed Combination

Kenji Inoue,1 Hua Piao,1 Mayumi Iwasa,1 Kyoko Ishida,2 Goji Tomita2 1Inouye Eye Hospital, Tokyo, Japan; 2Department of Ophthalmology, Toho University Ohashi Medical Center, Tokyo, JapanCorrespondence: Kenji InoueInouye Eye Hospital, Chiyoda-ku, Tokyo, JapanTel +81 3 3295 0911Fax +81 3 3295 0917Email...

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Autores principales:	Inoue K, Piao H, Iwasa M, Ishida K, Tomita G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	adverse reactions eye drops glaucoma intraocular pressure Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/fecffd67709648908a84922920246f99
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spelling	oai:doaj.org-article:fecffd67709648908a84922920246f992021-12-02T10:38:57ZShort-Term Efficacy and Safety of Switching from a Latanoprost/Timolol Fixed Combination to a Latanoprost/Carteolol Fixed Combination1177-5483https://doaj.org/article/fecffd67709648908a84922920246f992020-05-01T00:00:00Zhttps://www.dovepress.com/short-term-efficacy-and-safety-of-switching-from-a-latanoprosttimolol--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Kenji Inoue,1 Hua Piao,1 Mayumi Iwasa,1 Kyoko Ishida,2 Goji Tomita2 1Inouye Eye Hospital, Tokyo, Japan; 2Department of Ophthalmology, Toho University Ohashi Medical Center, Tokyo, JapanCorrespondence: Kenji InoueInouye Eye Hospital, Chiyoda-ku, Tokyo, JapanTel +81 3 3295 0911Fax +81 3 3295 0917Email inoue-k@inouye-eye.or.jpPurpose: To investigate the short-term intraocular pressure-lowering efficacy and safety of switching from a fixed combination of latanoprost/timolol to a fixed combination of latanoprost/carteolol.Patients and Methods: The subjects were 30 eyes of 30 adult patients with primary open-angle glaucoma, normal-tension glaucoma, or ocular hypertension who were using a latanoprost-/timolol-fixed combination with insufficient intraocular pressure-lowering efficacy or adverse reactions. The subjects were switched from once-daily latanoprost/timolol to once-daily latanoprost/carteolol with no washout interval. Intraocular pressure, tear film break-up time, corneal epithelial defects, conjunctival hyperemia, blood pressure, and pulse rate were measured and compared before and 1 and 3 months after switching. Patients were monitored for adverse reactions at each visit, and dropouts were recorded.Results: The mean intraocular pressure at 1 month (15.9± 3.1 mmHg) and 3 months (16.3± 3.8 mmHg) was not significantly different from that at baseline (16.1± 3.1 mmHg). The tear film break-up time and corneal epithelial defects were significantly improved after switching (p< 0.01 and p< 0.0001, respectively). There was a significant decrease in systolic blood pressure after 1 month and diastolic pressure after 3 months (p< 0.05). There was no significant change in pulse rate during the study. Adverse reactions (blurred vision, blepharitis, and conjunctival hyperemia) occurred in 3 patients (10.0%). Four patients (13.3%) discontinued treatment during the 3-month study period.Conclusion: A switch from a fixed combination of latanoprost/timolol to that of latanoprost/carteolol can maintain intraocular pressure and adherence with once-daily administration while improving tear film break-up time and corneal epithelial defects.Keywords: adverse reactions, eye drops, glaucoma, intraocular pressureInoue KPiao HIwasa MIshida KTomita GDove Medical Pressarticleadverse reactionseye dropsglaucomaintraocular pressureOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 1207-1214 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	adverse reactions eye drops glaucoma intraocular pressure Ophthalmology RE1-994
spellingShingle	adverse reactions eye drops glaucoma intraocular pressure Ophthalmology RE1-994 Inoue K Piao H Iwasa M Ishida K Tomita G Short-Term Efficacy and Safety of Switching from a Latanoprost/Timolol Fixed Combination to a Latanoprost/Carteolol Fixed Combination
description	Kenji Inoue,1 Hua Piao,1 Mayumi Iwasa,1 Kyoko Ishida,2 Goji Tomita2 1Inouye Eye Hospital, Tokyo, Japan; 2Department of Ophthalmology, Toho University Ohashi Medical Center, Tokyo, JapanCorrespondence: Kenji InoueInouye Eye Hospital, Chiyoda-ku, Tokyo, JapanTel +81 3 3295 0911Fax +81 3 3295 0917Email inoue-k@inouye-eye.or.jpPurpose: To investigate the short-term intraocular pressure-lowering efficacy and safety of switching from a fixed combination of latanoprost/timolol to a fixed combination of latanoprost/carteolol.Patients and Methods: The subjects were 30 eyes of 30 adult patients with primary open-angle glaucoma, normal-tension glaucoma, or ocular hypertension who were using a latanoprost-/timolol-fixed combination with insufficient intraocular pressure-lowering efficacy or adverse reactions. The subjects were switched from once-daily latanoprost/timolol to once-daily latanoprost/carteolol with no washout interval. Intraocular pressure, tear film break-up time, corneal epithelial defects, conjunctival hyperemia, blood pressure, and pulse rate were measured and compared before and 1 and 3 months after switching. Patients were monitored for adverse reactions at each visit, and dropouts were recorded.Results: The mean intraocular pressure at 1 month (15.9± 3.1 mmHg) and 3 months (16.3± 3.8 mmHg) was not significantly different from that at baseline (16.1± 3.1 mmHg). The tear film break-up time and corneal epithelial defects were significantly improved after switching (p< 0.01 and p< 0.0001, respectively). There was a significant decrease in systolic blood pressure after 1 month and diastolic pressure after 3 months (p< 0.05). There was no significant change in pulse rate during the study. Adverse reactions (blurred vision, blepharitis, and conjunctival hyperemia) occurred in 3 patients (10.0%). Four patients (13.3%) discontinued treatment during the 3-month study period.Conclusion: A switch from a fixed combination of latanoprost/timolol to that of latanoprost/carteolol can maintain intraocular pressure and adherence with once-daily administration while improving tear film break-up time and corneal epithelial defects.Keywords: adverse reactions, eye drops, glaucoma, intraocular pressure
format	article
author	Inoue K Piao H Iwasa M Ishida K Tomita G
author_facet	Inoue K Piao H Iwasa M Ishida K Tomita G
author_sort	Inoue K
title	Short-Term Efficacy and Safety of Switching from a Latanoprost/Timolol Fixed Combination to a Latanoprost/Carteolol Fixed Combination
title_short	Short-Term Efficacy and Safety of Switching from a Latanoprost/Timolol Fixed Combination to a Latanoprost/Carteolol Fixed Combination
title_full	Short-Term Efficacy and Safety of Switching from a Latanoprost/Timolol Fixed Combination to a Latanoprost/Carteolol Fixed Combination
title_fullStr	Short-Term Efficacy and Safety of Switching from a Latanoprost/Timolol Fixed Combination to a Latanoprost/Carteolol Fixed Combination
title_full_unstemmed	Short-Term Efficacy and Safety of Switching from a Latanoprost/Timolol Fixed Combination to a Latanoprost/Carteolol Fixed Combination
title_sort	short-term efficacy and safety of switching from a latanoprost/timolol fixed combination to a latanoprost/carteolol fixed combination
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/fecffd67709648908a84922920246f99
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Short-Term Efficacy and Safety of Switching from a Latanoprost/Timolol Fixed Combination to a Latanoprost/Carteolol Fixed Combination

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