Correlation between plasma proBNP, echocardiographic and clinical parameters in patientswith type 2 diabetes mellitus

Aims. To assess plasma level of N-terminal precursor for brain natriuretic peptide (proBNP) in patients with type 2 diabetes mellitus (T2DM) and arterial hypertension without overt heart failure ? and further estimation of its correlation with data from echocardiog- raphy and clinical parameters (s...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Irina Arkad'evna Bondar', Daria Vladimirovna Grazhdankina, S V Ivanov, Tatiana Viktorovna Panteleeva
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2013
Materias:	ischemic heart disease type 2 diabetes mellitus heart failure nt-probnp Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/fed770e8a2bd4759b7b862497fbe6bc7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fed770e8a2bd4759b7b862497fbe6bc7
record_format	dspace
spelling	oai:doaj.org-article:fed770e8a2bd4759b7b862497fbe6bc72021-11-14T09:00:18ZCorrelation between plasma proBNP, echocardiographic and clinical parameters in patientswith type 2 diabetes mellitus2072-03512072-037810.14341/2072-0351-3593https://doaj.org/article/fed770e8a2bd4759b7b862497fbe6bc72013-03-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/3593https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aims. To assess plasma level of N-terminal precursor for brain natriuretic peptide (proBNP) in patients with type 2 diabetes mellitus (T2DM) and arterial hypertension without overt heart failure ? and further estimation of its correlation with data from echocardiog- raphy and clinical parameters (severity of ischemic heart disease (IHD), age, sex, duration of T2DM and hypertension experience, characteristics of glucose and lipid metabolism, renal function. Materials and methods. We examined 94 patients with T2DM and arterial hypertension (aged 40?65 years), determining character- istics of glucose and lipid metabolism and renal function. We also performed six minute walk test, ECG, echocardiography and blood tests for N-terminal proBNP (NT-proBNP) in all study subjects. Acquired data was compared to the group of 30 healthy controls. Results. We observed an increase in plasma NT-proBNP in patients with IHD, history of left venctricular (LV) myocardial infarction or clinical signs of heart failure (II NYHA class and higher). Results from patients with T2DM and arterial hypertension but without IHD did not significantly differ from control group. Plasma NT-proBNP levels correlated with left ventricular ejection fraction, left ventricular EDD and ESD, but not with LV diastolic function parameters. Duration of T2DM and arterial hypertension, HbA1c levels,27Сахар ный диабет КардиологияСахарный диабет. 2013;(1):27?32BMI, lipid and uric acid metabolism parameters had no influence on plasma NT-proBNP in diabetic patients. Conclusion. According to our study, NT-proBNP was elevated in T2DM patients with IHD (and a history of LV myocardial infarc- tion in particular) or clinical evidence for heart failure beyond II NYHA class, thus indicating unfavorable prognosis for this group of patients and need for correction of therapy with subsequent re-evaluation of plasma NT-proBNP.Irina Arkad'evna Bondar'Daria Vladimirovna GrazhdankinaS V IvanovTatiana Viktorovna PanteleevaEndocrinology Research Centrearticleischemic heart diseasetype 2 diabetes mellitusheart failurent-probnpNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 16, Iss 1, Pp 27-32 (2013)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	ischemic heart disease type 2 diabetes mellitus heart failure nt-probnp Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	ischemic heart disease type 2 diabetes mellitus heart failure nt-probnp Nutritional diseases. Deficiency diseases RC620-627 Irina Arkad'evna Bondar' Daria Vladimirovna Grazhdankina S V Ivanov Tatiana Viktorovna Panteleeva Correlation between plasma proBNP, echocardiographic and clinical parameters in patientswith type 2 diabetes mellitus
description	Aims. To assess plasma level of N-terminal precursor for brain natriuretic peptide (proBNP) in patients with type 2 diabetes mellitus (T2DM) and arterial hypertension without overt heart failure ? and further estimation of its correlation with data from echocardiog- raphy and clinical parameters (severity of ischemic heart disease (IHD), age, sex, duration of T2DM and hypertension experience, characteristics of glucose and lipid metabolism, renal function. Materials and methods. We examined 94 patients with T2DM and arterial hypertension (aged 40?65 years), determining character- istics of glucose and lipid metabolism and renal function. We also performed six minute walk test, ECG, echocardiography and blood tests for N-terminal proBNP (NT-proBNP) in all study subjects. Acquired data was compared to the group of 30 healthy controls. Results. We observed an increase in plasma NT-proBNP in patients with IHD, history of left venctricular (LV) myocardial infarction or clinical signs of heart failure (II NYHA class and higher). Results from patients with T2DM and arterial hypertension but without IHD did not significantly differ from control group. Plasma NT-proBNP levels correlated with left ventricular ejection fraction, left ventricular EDD and ESD, but not with LV diastolic function parameters. Duration of T2DM and arterial hypertension, HbA1c levels,27Сахар ный диабет КардиологияСахарный диабет. 2013;(1):27?32BMI, lipid and uric acid metabolism parameters had no influence on plasma NT-proBNP in diabetic patients. Conclusion. According to our study, NT-proBNP was elevated in T2DM patients with IHD (and a history of LV myocardial infarc- tion in particular) or clinical evidence for heart failure beyond II NYHA class, thus indicating unfavorable prognosis for this group of patients and need for correction of therapy with subsequent re-evaluation of plasma NT-proBNP.
format	article
author	Irina Arkad'evna Bondar' Daria Vladimirovna Grazhdankina S V Ivanov Tatiana Viktorovna Panteleeva
author_facet	Irina Arkad'evna Bondar' Daria Vladimirovna Grazhdankina S V Ivanov Tatiana Viktorovna Panteleeva
author_sort	Irina Arkad'evna Bondar'
title	Correlation between plasma proBNP, echocardiographic and clinical parameters in patientswith type 2 diabetes mellitus
title_short	Correlation between plasma proBNP, echocardiographic and clinical parameters in patientswith type 2 diabetes mellitus
title_full	Correlation between plasma proBNP, echocardiographic and clinical parameters in patientswith type 2 diabetes mellitus
title_fullStr	Correlation between plasma proBNP, echocardiographic and clinical parameters in patientswith type 2 diabetes mellitus
title_full_unstemmed	Correlation between plasma proBNP, echocardiographic and clinical parameters in patientswith type 2 diabetes mellitus
title_sort	correlation between plasma probnp, echocardiographic and clinical parameters in patientswith type 2 diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2013
url	https://doaj.org/article/fed770e8a2bd4759b7b862497fbe6bc7
work_keys_str_mv	AT irinaarkadevnabondar correlationbetweenplasmaprobnpechocardiographicandclinicalparametersinpatientswithtype2diabetesmellitus AT dariavladimirovnagrazhdankina correlationbetweenplasmaprobnpechocardiographicandclinicalparametersinpatientswithtype2diabetesmellitus AT svivanov correlationbetweenplasmaprobnpechocardiographicandclinicalparametersinpatientswithtype2diabetesmellitus AT tatianaviktorovnapanteleeva correlationbetweenplasmaprobnpechocardiographicandclinicalparametersinpatientswithtype2diabetesmellitus
_version_	1718429629506650112

Correlation between plasma proBNP, echocardiographic and clinical parameters in patientswith type 2 diabetes mellitus

Ejemplares similares