Identifying DNase I hypersensitive sites as driver distal regulatory elements in breast cancer

Cancer driver mutations can occur within noncoding genomic sequences. Here, the authors develop a statistical approach to identify candidate noncoding driver mutations in DNase I hypersensitive sites in breast cancer and experimentally demonstrate they are regulatory elements of known cancer genes.

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Autores principales:	Matteo D′Antonio, Donate Weghorn, Agnieszka D′Antonio-Chronowska, Florence Coulet, Katrina M. Olson, Christopher DeBoever, Frauke Drees, Angelo Arias, Hakan Alakus, Andrea L. Richardson, Richard B. Schwab, Emma K. Farley, Shamil R. Sunyaev, Kelly A Frazer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fed8c71471284e789fe9fe3936d957c5
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spelling	oai:doaj.org-article:fed8c71471284e789fe9fe3936d957c52021-12-02T15:38:50ZIdentifying DNase I hypersensitive sites as driver distal regulatory elements in breast cancer10.1038/s41467-017-00100-x2041-1723https://doaj.org/article/fed8c71471284e789fe9fe3936d957c52017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00100-xhttps://doaj.org/toc/2041-1723Cancer driver mutations can occur within noncoding genomic sequences. Here, the authors develop a statistical approach to identify candidate noncoding driver mutations in DNase I hypersensitive sites in breast cancer and experimentally demonstrate they are regulatory elements of known cancer genes.Matteo D′AntonioDonate WeghornAgnieszka D′Antonio-ChronowskaFlorence CouletKatrina M. OlsonChristopher DeBoeverFrauke DreesAngelo AriasHakan AlakusAndrea L. RichardsonRichard B. SchwabEmma K. FarleyShamil R. SunyaevKelly A FrazerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matteo D′Antonio Donate Weghorn Agnieszka D′Antonio-Chronowska Florence Coulet Katrina M. Olson Christopher DeBoever Frauke Drees Angelo Arias Hakan Alakus Andrea L. Richardson Richard B. Schwab Emma K. Farley Shamil R. Sunyaev Kelly A Frazer Identifying DNase I hypersensitive sites as driver distal regulatory elements in breast cancer
description	Cancer driver mutations can occur within noncoding genomic sequences. Here, the authors develop a statistical approach to identify candidate noncoding driver mutations in DNase I hypersensitive sites in breast cancer and experimentally demonstrate they are regulatory elements of known cancer genes.
format	article
author	Matteo D′Antonio Donate Weghorn Agnieszka D′Antonio-Chronowska Florence Coulet Katrina M. Olson Christopher DeBoever Frauke Drees Angelo Arias Hakan Alakus Andrea L. Richardson Richard B. Schwab Emma K. Farley Shamil R. Sunyaev Kelly A Frazer
author_facet	Matteo D′Antonio Donate Weghorn Agnieszka D′Antonio-Chronowska Florence Coulet Katrina M. Olson Christopher DeBoever Frauke Drees Angelo Arias Hakan Alakus Andrea L. Richardson Richard B. Schwab Emma K. Farley Shamil R. Sunyaev Kelly A Frazer
author_sort	Matteo D′Antonio
title	Identifying DNase I hypersensitive sites as driver distal regulatory elements in breast cancer
title_short	Identifying DNase I hypersensitive sites as driver distal regulatory elements in breast cancer
title_full	Identifying DNase I hypersensitive sites as driver distal regulatory elements in breast cancer
title_fullStr	Identifying DNase I hypersensitive sites as driver distal regulatory elements in breast cancer
title_full_unstemmed	Identifying DNase I hypersensitive sites as driver distal regulatory elements in breast cancer
title_sort	identifying dnase i hypersensitive sites as driver distal regulatory elements in breast cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/fed8c71471284e789fe9fe3936d957c5
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Identifying DNase I hypersensitive sites as driver distal regulatory elements in breast cancer

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