Transcript-targeted analysis reveals isoform alterations and double-hop fusions in breast cancer

Namba et al develop a new pipeline called MuSTA to enable the efficient assembly of transcriptome from long-read sequencing data of breast cancer samples. This method enables the authors to discover subtype-specific isoforms, find that fusion transcript structures depend on their genomic context and...

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Autores principales:	Shinichi Namba, Toshihide Ueno, Shinya Kojima, Kenya Kobayashi, Katsushige Kawase, Yosuke Tanaka, Satoshi Inoue, Fumishi Kishigami, Shusuke Kawashima, Noriko Maeda, Tomoko Ogawa, Shoichi Hazama, Yosuke Togashi, Mizuo Ando, Yuichi Shiraishi, Hiroyuki Mano, Masahito Kawazu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/fed8f30c93874058b219cc151c3f2be3
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spelling	oai:doaj.org-article:fed8f30c93874058b219cc151c3f2be32021-11-28T12:10:23ZTranscript-targeted analysis reveals isoform alterations and double-hop fusions in breast cancer10.1038/s42003-021-02833-42399-3642https://doaj.org/article/fed8f30c93874058b219cc151c3f2be32021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02833-4https://doaj.org/toc/2399-3642Namba et al develop a new pipeline called MuSTA to enable the efficient assembly of transcriptome from long-read sequencing data of breast cancer samples. This method enables the authors to discover subtype-specific isoforms, find that fusion transcript structures depend on their genomic context and identify a double-hop fusion that results in aberrant expression of an endogenous retroviral gene.Shinichi NambaToshihide UenoShinya KojimaKenya KobayashiKatsushige KawaseYosuke TanakaSatoshi InoueFumishi KishigamiShusuke KawashimaNoriko MaedaTomoko OgawaShoichi HazamaYosuke TogashiMizuo AndoYuichi ShiraishiHiroyuki ManoMasahito KawazuNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Shinichi Namba Toshihide Ueno Shinya Kojima Kenya Kobayashi Katsushige Kawase Yosuke Tanaka Satoshi Inoue Fumishi Kishigami Shusuke Kawashima Noriko Maeda Tomoko Ogawa Shoichi Hazama Yosuke Togashi Mizuo Ando Yuichi Shiraishi Hiroyuki Mano Masahito Kawazu Transcript-targeted analysis reveals isoform alterations and double-hop fusions in breast cancer
description	Namba et al develop a new pipeline called MuSTA to enable the efficient assembly of transcriptome from long-read sequencing data of breast cancer samples. This method enables the authors to discover subtype-specific isoforms, find that fusion transcript structures depend on their genomic context and identify a double-hop fusion that results in aberrant expression of an endogenous retroviral gene.
format	article
author	Shinichi Namba Toshihide Ueno Shinya Kojima Kenya Kobayashi Katsushige Kawase Yosuke Tanaka Satoshi Inoue Fumishi Kishigami Shusuke Kawashima Noriko Maeda Tomoko Ogawa Shoichi Hazama Yosuke Togashi Mizuo Ando Yuichi Shiraishi Hiroyuki Mano Masahito Kawazu
author_facet	Shinichi Namba Toshihide Ueno Shinya Kojima Kenya Kobayashi Katsushige Kawase Yosuke Tanaka Satoshi Inoue Fumishi Kishigami Shusuke Kawashima Noriko Maeda Tomoko Ogawa Shoichi Hazama Yosuke Togashi Mizuo Ando Yuichi Shiraishi Hiroyuki Mano Masahito Kawazu
author_sort	Shinichi Namba
title	Transcript-targeted analysis reveals isoform alterations and double-hop fusions in breast cancer
title_short	Transcript-targeted analysis reveals isoform alterations and double-hop fusions in breast cancer
title_full	Transcript-targeted analysis reveals isoform alterations and double-hop fusions in breast cancer
title_fullStr	Transcript-targeted analysis reveals isoform alterations and double-hop fusions in breast cancer
title_full_unstemmed	Transcript-targeted analysis reveals isoform alterations and double-hop fusions in breast cancer
title_sort	transcript-targeted analysis reveals isoform alterations and double-hop fusions in breast cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fed8f30c93874058b219cc151c3f2be3
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Transcript-targeted analysis reveals isoform alterations and double-hop fusions in breast cancer

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