Diagnosis and Management of Immunotherapy-related Liver Toxicity

Immune checkpoint inhibitors have revolutionized the treatment of cancer. With the increasing use of immunotherapy, clinicians have observed that immunotherapy is often related to a spectrum of adverse events. Liver toxicity is one of the most common and severe immune-related adverse events. It is v...

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Autores principales:	HUA Yuwei, ZHAO Lin
Formato:	article
Lenguaje:	ZH
Publicado:	Editorial Office of Medical Journal of Peking Union Medical College Hospital 2021
Materias:	immunotherapy-related liver toxicity immune checkpoint inhibitors immune-related adverse events programmed death-1 cytotoxic t lymphocyte associated antigen-4 Medicine R
Acceso en línea:	https://doaj.org/article/fedbee7a61344b0c8c947a5280bf250b
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spelling	oai:doaj.org-article:fedbee7a61344b0c8c947a5280bf250b2021-12-01T01:42:33ZDiagnosis and Management of Immunotherapy-related Liver Toxicity1674-908110.12290/xhyxzz.2021-0138https://doaj.org/article/fedbee7a61344b0c8c947a5280bf250b2021-10-01T00:00:00Zhttps://xhyxzz.pumch.cn/en/article/doi/10.12290/xhyxzz.2021-0138https://doaj.org/toc/1674-9081Immune checkpoint inhibitors have revolutionized the treatment of cancer. With the increasing use of immunotherapy, clinicians have observed that immunotherapy is often related to a spectrum of adverse events. Liver toxicity is one of the most common and severe immune-related adverse events. It is very important to increase awareness and outline a clear and detailed strategy of managing immune-related liver toxicity. Some guidelines have published systematic advice on the management of immune-related liver toxicity. However, there are controversial problems remaining, including the levels of liver toxicity, the minimal effective dosage of hormone, treatments for hormone-refractory patients, and immunotherapy re-challenge. Additional, finding predictors with high specificity and sensitivity is a pressing concern.HUA YuweiZHAO LinEditorial Office of Medical Journal of Peking Union Medical College Hospitalarticleimmunotherapy-related liver toxicityimmune checkpoint inhibitorsimmune-related adverse eventsprogrammed death-1cytotoxic t lymphocyte associated antigen-4MedicineRZHXiehe Yixue Zazhi, Vol 12, Iss 5, Pp 798-806 (2021)
institution	DOAJ
collection	DOAJ
language	ZH
topic	immunotherapy-related liver toxicity immune checkpoint inhibitors immune-related adverse events programmed death-1 cytotoxic t lymphocyte associated antigen-4 Medicine R
spellingShingle	immunotherapy-related liver toxicity immune checkpoint inhibitors immune-related adverse events programmed death-1 cytotoxic t lymphocyte associated antigen-4 Medicine R HUA Yuwei ZHAO Lin Diagnosis and Management of Immunotherapy-related Liver Toxicity
description	Immune checkpoint inhibitors have revolutionized the treatment of cancer. With the increasing use of immunotherapy, clinicians have observed that immunotherapy is often related to a spectrum of adverse events. Liver toxicity is one of the most common and severe immune-related adverse events. It is very important to increase awareness and outline a clear and detailed strategy of managing immune-related liver toxicity. Some guidelines have published systematic advice on the management of immune-related liver toxicity. However, there are controversial problems remaining, including the levels of liver toxicity, the minimal effective dosage of hormone, treatments for hormone-refractory patients, and immunotherapy re-challenge. Additional, finding predictors with high specificity and sensitivity is a pressing concern.
format	article
author	HUA Yuwei ZHAO Lin
author_facet	HUA Yuwei ZHAO Lin
author_sort	HUA Yuwei
title	Diagnosis and Management of Immunotherapy-related Liver Toxicity
title_short	Diagnosis and Management of Immunotherapy-related Liver Toxicity
title_full	Diagnosis and Management of Immunotherapy-related Liver Toxicity
title_fullStr	Diagnosis and Management of Immunotherapy-related Liver Toxicity
title_full_unstemmed	Diagnosis and Management of Immunotherapy-related Liver Toxicity
title_sort	diagnosis and management of immunotherapy-related liver toxicity
publisher	Editorial Office of Medical Journal of Peking Union Medical College Hospital
publishDate	2021
url	https://doaj.org/article/fedbee7a61344b0c8c947a5280bf250b
work_keys_str_mv	AT huayuwei diagnosisandmanagementofimmunotherapyrelatedlivertoxicity AT zhaolin diagnosisandmanagementofimmunotherapyrelatedlivertoxicity
_version_	1718406000676962304

Diagnosis and Management of Immunotherapy-related Liver Toxicity

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