Consistent RNA sequencing contamination in GTEx and other data sets

Sample contamination has been reported in high throughput RNA sequencing. Here the authors analyze the RNA sequencing data from the Genotype-Tissue Expression project and describe how highly expressed, tissue specific genes contaminate across samples, which is corroborated in other data sets.

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Autores principales: Tim O. Nieuwenhuis, Stephanie Y. Yang, Rohan X. Verma, Vamsee Pillalamarri, Dan E. Arking, Avi Z. Rosenberg, Matthew N. McCall, Marc K. Halushka
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/fede4787d2dc40708b7ce5f17be141ab
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spelling oai:doaj.org-article:fede4787d2dc40708b7ce5f17be141ab2021-12-02T15:39:21ZConsistent RNA sequencing contamination in GTEx and other data sets10.1038/s41467-020-15821-92041-1723https://doaj.org/article/fede4787d2dc40708b7ce5f17be141ab2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15821-9https://doaj.org/toc/2041-1723Sample contamination has been reported in high throughput RNA sequencing. Here the authors analyze the RNA sequencing data from the Genotype-Tissue Expression project and describe how highly expressed, tissue specific genes contaminate across samples, which is corroborated in other data sets.Tim O. NieuwenhuisStephanie Y. YangRohan X. VermaVamsee PillalamarriDan E. ArkingAvi Z. RosenbergMatthew N. McCallMarc K. HalushkaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Tim O. Nieuwenhuis
Stephanie Y. Yang
Rohan X. Verma
Vamsee Pillalamarri
Dan E. Arking
Avi Z. Rosenberg
Matthew N. McCall
Marc K. Halushka
Consistent RNA sequencing contamination in GTEx and other data sets
description Sample contamination has been reported in high throughput RNA sequencing. Here the authors analyze the RNA sequencing data from the Genotype-Tissue Expression project and describe how highly expressed, tissue specific genes contaminate across samples, which is corroborated in other data sets.
format article
author Tim O. Nieuwenhuis
Stephanie Y. Yang
Rohan X. Verma
Vamsee Pillalamarri
Dan E. Arking
Avi Z. Rosenberg
Matthew N. McCall
Marc K. Halushka
author_facet Tim O. Nieuwenhuis
Stephanie Y. Yang
Rohan X. Verma
Vamsee Pillalamarri
Dan E. Arking
Avi Z. Rosenberg
Matthew N. McCall
Marc K. Halushka
author_sort Tim O. Nieuwenhuis
title Consistent RNA sequencing contamination in GTEx and other data sets
title_short Consistent RNA sequencing contamination in GTEx and other data sets
title_full Consistent RNA sequencing contamination in GTEx and other data sets
title_fullStr Consistent RNA sequencing contamination in GTEx and other data sets
title_full_unstemmed Consistent RNA sequencing contamination in GTEx and other data sets
title_sort consistent rna sequencing contamination in gtex and other data sets
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/fede4787d2dc40708b7ce5f17be141ab
work_keys_str_mv AT timonieuwenhuis consistentrnasequencingcontaminationingtexandotherdatasets
AT stephanieyyang consistentrnasequencingcontaminationingtexandotherdatasets
AT rohanxverma consistentrnasequencingcontaminationingtexandotherdatasets
AT vamseepillalamarri consistentrnasequencingcontaminationingtexandotherdatasets
AT danearking consistentrnasequencingcontaminationingtexandotherdatasets
AT avizrosenberg consistentrnasequencingcontaminationingtexandotherdatasets
AT matthewnmccall consistentrnasequencingcontaminationingtexandotherdatasets
AT marckhalushka consistentrnasequencingcontaminationingtexandotherdatasets
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