Serotype-dependent recombinant adeno-associated vector (AAV) infection of Epstein–Barr virus-positive B-cells, towards recombinant AAV-based therapy of focal EBV + lymphoproliferative disorders

Serotype-dependent recombinant adeno-associated vector (AAV) infection of Epstein–Barr virus-positive B-cells, towards recombinant AAV-based therapy of focal EBV + lymphoproliferative disorders

Abstract Background B-cell proliferative disorders, such as post-transplant lymphoproliferative disease (PTLD), are increased among persons afflicted by T-cell compromise. Most are Epstein–Barr virus (EBV) + and can first present with a focal lesion. Direct introduction of oncolytic viruses into loc...

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Autores principales: Elham Ahmadi, Mehrdad Ravanshad, Jun Xie, Rajesh Panigrahi, Sandeep S. Jubbal, Santosh Kumar Guru, Gao Guangping, Mazyar Ziyaeyan, Joyce Fingeroth
Formato: article
Lenguaje:EN
Publicado: BMC 2021
Materias:
rAAV
EBV
B-cells
Focal tumors
PTLD
Mononucleosis
Infectious and parasitic diseases
RC109-216
Acceso en línea:https://doaj.org/article/fee1d2b15166479ea75c08b4d27cf077
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