IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection

Rosa et al. find that genes associated with Interferon (IFN) signaling, neutrophil degranulation and innate immune pathways are induced in the lungs of macaques in response to SARS-CoV-2 infection, whereas genes associated with collagen formation and regulation are reduced. Authors also note an over...

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Autores principales:	Bruce A. Rosa, Mushtaq Ahmed, Dhiraj K. Singh, José Alberto Choreño-Parra, Journey Cole, Luis Armando Jiménez-Álvarez, Tatiana Sofía Rodríguez-Reyna, Bindu Singh, Olga Gonzalez, Ricardo Carrion, Larry S. Schlesinger, John Martin, Joaquín Zúñiga, Makedonka Mitreva, Deepak Kaushal, Shabaana A. Khader
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/fee1d848484c4499aa50fa45ecb7d32f
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spelling	oai:doaj.org-article:fee1d848484c4499aa50fa45ecb7d32f2021-12-02T13:19:27ZIFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection10.1038/s42003-021-01829-42399-3642https://doaj.org/article/fee1d848484c4499aa50fa45ecb7d32f2021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01829-4https://doaj.org/toc/2399-3642Rosa et al. find that genes associated with Interferon (IFN) signaling, neutrophil degranulation and innate immune pathways are induced in the lungs of macaques in response to SARS-CoV-2 infection, whereas genes associated with collagen formation and regulation are reduced. Authors also note an overlap of genes associated with SARS-CoV-2 infection and tuberculosis, altogether providing new insights into the immunopathogenesis of COVID-19 disease.Bruce A. RosaMushtaq AhmedDhiraj K. SinghJosé Alberto Choreño-ParraJourney ColeLuis Armando Jiménez-ÁlvarezTatiana Sofía Rodríguez-ReynaBindu SinghOlga GonzalezRicardo CarrionLarry S. SchlesingerJohn MartinJoaquín ZúñigaMakedonka MitrevaDeepak KaushalShabaana A. KhaderNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Bruce A. Rosa Mushtaq Ahmed Dhiraj K. Singh José Alberto Choreño-Parra Journey Cole Luis Armando Jiménez-Álvarez Tatiana Sofía Rodríguez-Reyna Bindu Singh Olga Gonzalez Ricardo Carrion Larry S. Schlesinger John Martin Joaquín Zúñiga Makedonka Mitreva Deepak Kaushal Shabaana A. Khader IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection
description	Rosa et al. find that genes associated with Interferon (IFN) signaling, neutrophil degranulation and innate immune pathways are induced in the lungs of macaques in response to SARS-CoV-2 infection, whereas genes associated with collagen formation and regulation are reduced. Authors also note an overlap of genes associated with SARS-CoV-2 infection and tuberculosis, altogether providing new insights into the immunopathogenesis of COVID-19 disease.
format	article
author	Bruce A. Rosa Mushtaq Ahmed Dhiraj K. Singh José Alberto Choreño-Parra Journey Cole Luis Armando Jiménez-Álvarez Tatiana Sofía Rodríguez-Reyna Bindu Singh Olga Gonzalez Ricardo Carrion Larry S. Schlesinger John Martin Joaquín Zúñiga Makedonka Mitreva Deepak Kaushal Shabaana A. Khader
author_facet	Bruce A. Rosa Mushtaq Ahmed Dhiraj K. Singh José Alberto Choreño-Parra Journey Cole Luis Armando Jiménez-Álvarez Tatiana Sofía Rodríguez-Reyna Bindu Singh Olga Gonzalez Ricardo Carrion Larry S. Schlesinger John Martin Joaquín Zúñiga Makedonka Mitreva Deepak Kaushal Shabaana A. Khader
author_sort	Bruce A. Rosa
title	IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection
title_short	IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection
title_full	IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection
title_fullStr	IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection
title_full_unstemmed	IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection
title_sort	ifn signaling and neutrophil degranulation transcriptional signatures are induced during sars-cov-2 infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fee1d848484c4499aa50fa45ecb7d32f
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IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection

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