A simple optogenetic MAPK inhibitor design reveals resonance between transcription-regulating circuitry and temporally-encoded inputs

Light-sensitive regulators of protein kinases could offer valuable insights into intracellular signalling. Here the authors design an optogenetic inhibitor of c-Jun N-terminal kinase (JNK) and show evidence for resonance in JNK signalling circuits in neurons, and use the same design principle to dev...

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Autores principales:	Raquel M. Melero-Fernandez de Mera, Li-Li Li, Arkadiusz Popinigis, Katryna Cisek, Minna Tuittila, Leena Yadav, Andrius Serva, Michael J. Courtney
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fee39ade45e447a1bfd925b99e2fe32f
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spelling	oai:doaj.org-article:fee39ade45e447a1bfd925b99e2fe32f2021-12-02T15:37:01ZA simple optogenetic MAPK inhibitor design reveals resonance between transcription-regulating circuitry and temporally-encoded inputs10.1038/ncomms150172041-1723https://doaj.org/article/fee39ade45e447a1bfd925b99e2fe32f2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15017https://doaj.org/toc/2041-1723Light-sensitive regulators of protein kinases could offer valuable insights into intracellular signalling. Here the authors design an optogenetic inhibitor of c-Jun N-terminal kinase (JNK) and show evidence for resonance in JNK signalling circuits in neurons, and use the same design principle to develop an inhibitor for p38MAPK.Raquel M. Melero-Fernandez de MeraLi-Li LiArkadiusz PopinigisKatryna CisekMinna TuittilaLeena YadavAndrius ServaMichael J. CourtneyNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Raquel M. Melero-Fernandez de Mera Li-Li Li Arkadiusz Popinigis Katryna Cisek Minna Tuittila Leena Yadav Andrius Serva Michael J. Courtney A simple optogenetic MAPK inhibitor design reveals resonance between transcription-regulating circuitry and temporally-encoded inputs
description	Light-sensitive regulators of protein kinases could offer valuable insights into intracellular signalling. Here the authors design an optogenetic inhibitor of c-Jun N-terminal kinase (JNK) and show evidence for resonance in JNK signalling circuits in neurons, and use the same design principle to develop an inhibitor for p38MAPK.
format	article
author	Raquel M. Melero-Fernandez de Mera Li-Li Li Arkadiusz Popinigis Katryna Cisek Minna Tuittila Leena Yadav Andrius Serva Michael J. Courtney
author_facet	Raquel M. Melero-Fernandez de Mera Li-Li Li Arkadiusz Popinigis Katryna Cisek Minna Tuittila Leena Yadav Andrius Serva Michael J. Courtney
author_sort	Raquel M. Melero-Fernandez de Mera
title	A simple optogenetic MAPK inhibitor design reveals resonance between transcription-regulating circuitry and temporally-encoded inputs
title_short	A simple optogenetic MAPK inhibitor design reveals resonance between transcription-regulating circuitry and temporally-encoded inputs
title_full	A simple optogenetic MAPK inhibitor design reveals resonance between transcription-regulating circuitry and temporally-encoded inputs
title_fullStr	A simple optogenetic MAPK inhibitor design reveals resonance between transcription-regulating circuitry and temporally-encoded inputs
title_full_unstemmed	A simple optogenetic MAPK inhibitor design reveals resonance between transcription-regulating circuitry and temporally-encoded inputs
title_sort	simple optogenetic mapk inhibitor design reveals resonance between transcription-regulating circuitry and temporally-encoded inputs
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/fee39ade45e447a1bfd925b99e2fe32f
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A simple optogenetic MAPK inhibitor design reveals resonance between transcription-regulating circuitry and temporally-encoded inputs

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