Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis

BRAF-MAPK activating mutations are reported in histiocytoses—hematological neoplasms with widespread pro-inflammatory myeloid cells. Here, the authors show that an activating mutant BRAF in haematopoietic stem and progenitor cells causes an oncogene-induced senescence response leading to myeloid res...

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Autores principales:	Riccardo Biavasco, Emanuele Lettera, Kety Giannetti, Diego Gilioli, Stefano Beretta, Anastasia Conti, Serena Scala, Daniela Cesana, Pierangela Gallina, Margherita Norelli, Luca Basso-Ricci, Attilio Bondanza, Giulio Cavalli, Maurilio Ponzoni, Lorenzo Dagna, Claudio Doglioni, Alessandro Aiuti, Ivan Merelli, Raffaella Di Micco, Eugenio Montini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fee49380e85c4d6fa86a0b00aa340aa0
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spelling	oai:doaj.org-article:fee49380e85c4d6fa86a0b00aa340aa02021-12-02T18:47:00ZOncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis10.1038/s41467-021-24876-12041-1723https://doaj.org/article/fee49380e85c4d6fa86a0b00aa340aa02021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24876-1https://doaj.org/toc/2041-1723BRAF-MAPK activating mutations are reported in histiocytoses—hematological neoplasms with widespread pro-inflammatory myeloid cells. Here, the authors show that an activating mutant BRAF in haematopoietic stem and progenitor cells causes an oncogene-induced senescence response leading to myeloid restricted haematopoiesis, inflammation and histiocytosis.Riccardo BiavascoEmanuele LetteraKety GiannettiDiego GilioliStefano BerettaAnastasia ContiSerena ScalaDaniela CesanaPierangela GallinaMargherita NorelliLuca Basso-RicciAttilio BondanzaGiulio CavalliMaurilio PonzoniLorenzo DagnaClaudio DoglioniAlessandro AiutiIvan MerelliRaffaella Di MiccoEugenio MontiniNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Riccardo Biavasco Emanuele Lettera Kety Giannetti Diego Gilioli Stefano Beretta Anastasia Conti Serena Scala Daniela Cesana Pierangela Gallina Margherita Norelli Luca Basso-Ricci Attilio Bondanza Giulio Cavalli Maurilio Ponzoni Lorenzo Dagna Claudio Doglioni Alessandro Aiuti Ivan Merelli Raffaella Di Micco Eugenio Montini Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis
description	BRAF-MAPK activating mutations are reported in histiocytoses—hematological neoplasms with widespread pro-inflammatory myeloid cells. Here, the authors show that an activating mutant BRAF in haematopoietic stem and progenitor cells causes an oncogene-induced senescence response leading to myeloid restricted haematopoiesis, inflammation and histiocytosis.
format	article
author	Riccardo Biavasco Emanuele Lettera Kety Giannetti Diego Gilioli Stefano Beretta Anastasia Conti Serena Scala Daniela Cesana Pierangela Gallina Margherita Norelli Luca Basso-Ricci Attilio Bondanza Giulio Cavalli Maurilio Ponzoni Lorenzo Dagna Claudio Doglioni Alessandro Aiuti Ivan Merelli Raffaella Di Micco Eugenio Montini
author_facet	Riccardo Biavasco Emanuele Lettera Kety Giannetti Diego Gilioli Stefano Beretta Anastasia Conti Serena Scala Daniela Cesana Pierangela Gallina Margherita Norelli Luca Basso-Ricci Attilio Bondanza Giulio Cavalli Maurilio Ponzoni Lorenzo Dagna Claudio Doglioni Alessandro Aiuti Ivan Merelli Raffaella Di Micco Eugenio Montini
author_sort	Riccardo Biavasco
title	Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis
title_short	Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis
title_full	Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis
title_fullStr	Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis
title_full_unstemmed	Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis
title_sort	oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fee49380e85c4d6fa86a0b00aa340aa0
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Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis

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