Diffusion Tensor Tractography Characteristics of White Matter Tracts are Associated with Post-Stroke Depression

Lijun Deng,1 Rubo Sui,1 Lei Zhang2 1Department of Neurology, First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, People’s Republic of China; 2School of Nursing, Jinzhou Medical University, Jinzhou, Liaoning, People’s Republic of ChinaCorrespondence: Rubo S...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Deng L, Sui R, Zhang L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	post-stroke depression white matter tracts diffusion tensor imaging diffusion tensor tractography Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/fee7ababc6a74443b334773e99dbb5a0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fee7ababc6a74443b334773e99dbb5a0
record_format	dspace
spelling	oai:doaj.org-article:fee7ababc6a74443b334773e99dbb5a02021-12-02T14:17:44ZDiffusion Tensor Tractography Characteristics of White Matter Tracts are Associated with Post-Stroke Depression1178-2021https://doaj.org/article/fee7ababc6a74443b334773e99dbb5a02021-01-01T00:00:00Zhttps://www.dovepress.com/diffusion-tensor-tractography-characteristics-of-white-matter-tracts-a-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Lijun Deng,1 Rubo Sui,1 Lei Zhang2 1Department of Neurology, First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, People’s Republic of China; 2School of Nursing, Jinzhou Medical University, Jinzhou, Liaoning, People’s Republic of ChinaCorrespondence: Rubo SuiDepartment of Neurology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, People’s Republic of ChinaTel +8613204525199Email 627079227@qq.comPurpose: To analyze the changes in white matter tracts in patients with post-stroke depression (PSD), and the correlation between these changes and the depressive state.Patients and Methods: The numbers of white matter tracts and corresponding fractional anisotropy (FA) in the acute phase (the onset time < 72 hours) were examined in each subject by diffusion tensor tractography (DTT). Diffusion tensor imaging (DTT), a new development of diffusion tensor imaging (DTI), enables visualization of white matter fiber tracts, which are thought to be closely related to the occurrence of PSD, According to the scores of Hamilton Depression Scale (HAMD) recorded at the 2nd week, 1st month, 3rd month, 6th month, and 12th month, forty patients were randomly selected and were classified into PSD group (n=20), non-depression post-stroke group (N-PSD, n=20), and control normal group (NORM, n=20), respectively. Correlations between the number of bundles (lines) in the white matter tract and corresponding FA, and HAMD score were finally assessed.Results: 1) FAs of the ipsilesional crossed corticocerebellar tract, the corticospinal tract, and the anterior thalamic radiation in PSD group were significantly lower than those in N-PSD and NORM groups (P< 0.01); 2) Lines in the three areas in the PSD group were significantly lower than those in the N-PSD and NORM groups (P< 0.01); and 3) FA and lines in the three areas of PSD patients were negatively correlated to HAMD scores (correlation coefficient=− 0.586, − 0.793, − 0.626, − 0.533, − 0.642, and − 0.524, respectively, all P< 0.05).Conclusion: FA and lines of the ipsilesional crossed corticocerebellar tract, the corticospinal tract, and the anterior thalamic radiation in PSD patients are significantly correlated to the depressive state. The crossed corticocerebellar tract, the corticospinal tract and the anterior thalamic radiation are involved in the development of PSD.Keywords: post-stroke depression, white matter tracts, diffusion tensor imaging, diffusion tensor tractographyDeng LSui RZhang LDove Medical Pressarticlepost-stroke depressionwhite matter tractsdiffusion tensor imagingdiffusion tensor tractographyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 167-181 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	post-stroke depression white matter tracts diffusion tensor imaging diffusion tensor tractography Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	post-stroke depression white matter tracts diffusion tensor imaging diffusion tensor tractography Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Deng L Sui R Zhang L Diffusion Tensor Tractography Characteristics of White Matter Tracts are Associated with Post-Stroke Depression
description	Lijun Deng,1 Rubo Sui,1 Lei Zhang2 1Department of Neurology, First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, People’s Republic of China; 2School of Nursing, Jinzhou Medical University, Jinzhou, Liaoning, People’s Republic of ChinaCorrespondence: Rubo SuiDepartment of Neurology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, People’s Republic of ChinaTel +8613204525199Email 627079227@qq.comPurpose: To analyze the changes in white matter tracts in patients with post-stroke depression (PSD), and the correlation between these changes and the depressive state.Patients and Methods: The numbers of white matter tracts and corresponding fractional anisotropy (FA) in the acute phase (the onset time < 72 hours) were examined in each subject by diffusion tensor tractography (DTT). Diffusion tensor imaging (DTT), a new development of diffusion tensor imaging (DTI), enables visualization of white matter fiber tracts, which are thought to be closely related to the occurrence of PSD, According to the scores of Hamilton Depression Scale (HAMD) recorded at the 2nd week, 1st month, 3rd month, 6th month, and 12th month, forty patients were randomly selected and were classified into PSD group (n=20), non-depression post-stroke group (N-PSD, n=20), and control normal group (NORM, n=20), respectively. Correlations between the number of bundles (lines) in the white matter tract and corresponding FA, and HAMD score were finally assessed.Results: 1) FAs of the ipsilesional crossed corticocerebellar tract, the corticospinal tract, and the anterior thalamic radiation in PSD group were significantly lower than those in N-PSD and NORM groups (P< 0.01); 2) Lines in the three areas in the PSD group were significantly lower than those in the N-PSD and NORM groups (P< 0.01); and 3) FA and lines in the three areas of PSD patients were negatively correlated to HAMD scores (correlation coefficient=− 0.586, − 0.793, − 0.626, − 0.533, − 0.642, and − 0.524, respectively, all P< 0.05).Conclusion: FA and lines of the ipsilesional crossed corticocerebellar tract, the corticospinal tract, and the anterior thalamic radiation in PSD patients are significantly correlated to the depressive state. The crossed corticocerebellar tract, the corticospinal tract and the anterior thalamic radiation are involved in the development of PSD.Keywords: post-stroke depression, white matter tracts, diffusion tensor imaging, diffusion tensor tractography
format	article
author	Deng L Sui R Zhang L
author_facet	Deng L Sui R Zhang L
author_sort	Deng L
title	Diffusion Tensor Tractography Characteristics of White Matter Tracts are Associated with Post-Stroke Depression
title_short	Diffusion Tensor Tractography Characteristics of White Matter Tracts are Associated with Post-Stroke Depression
title_full	Diffusion Tensor Tractography Characteristics of White Matter Tracts are Associated with Post-Stroke Depression
title_fullStr	Diffusion Tensor Tractography Characteristics of White Matter Tracts are Associated with Post-Stroke Depression
title_full_unstemmed	Diffusion Tensor Tractography Characteristics of White Matter Tracts are Associated with Post-Stroke Depression
title_sort	diffusion tensor tractography characteristics of white matter tracts are associated with post-stroke depression
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/fee7ababc6a74443b334773e99dbb5a0
work_keys_str_mv	AT dengl diffusiontensortractographycharacteristicsofwhitemattertractsareassociatedwithpoststrokedepression AT suir diffusiontensortractographycharacteristicsofwhitemattertractsareassociatedwithpoststrokedepression AT zhangl diffusiontensortractographycharacteristicsofwhitemattertractsareassociatedwithpoststrokedepression
_version_	1718391644178350080

Diffusion Tensor Tractography Characteristics of White Matter Tracts are Associated with Post-Stroke Depression

Ejemplares similares