Aminoguanidine Prevents the Oxidative Stress, Inhibiting Elements of Inflammation, Endothelial Activation, Mesenchymal Markers, and Confers a Renoprotective Effect in Renal Ischemia and Reperfusion Injury

Aminoguanidine Prevents the Oxidative Stress, Inhibiting Elements of Inflammation, Endothelial Activation, Mesenchymal Markers, and Confers a Renoprotective Effect in Renal Ischemia and Reperfusion Injury

Oxidative stress produces macromolecules dysfunction and cellular damage. Renal ischemia-reperfusion injury (IRI) induces oxidative stress, inflammation, epithelium and endothelium damage, and cessation of renal function. The IRI is an inevitable process during kidney transplantation. Preliminary st...

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Bibliographic Details
Main Authors: Consuelo Pasten, Mauricio Lozano, Jocelyn Rocco, Flavio Carrión, Cristobal Alvarado, Jéssica Liberona, Luis Michea, Carlos E. Irarrázabal
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
aminoguanidine
antioxidants
oxidative stress
ischemia-reperfusion injury
renal protection
Therapeutics. Pharmacology
RM1-950
Online Access:https://doaj.org/article/fee9d9f49e0143bd846d5ad3c90ca4e8
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https://doaj.org/article/fee9d9f49e0143bd846d5ad3c90ca4e8

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