Potent PDE4 inhibitor activates AMPK and Sirt1 to induce mitochondrial biogenesis.

Potent PDE4 inhibitor activates AMPK and Sirt1 to induce mitochondrial biogenesis.

AMP-activated protein kinase (AMPK) is an evolutionarily conserved energy sensor. Activation of AMPK leads to a number of metabolic benefits, including improved mitochondrial function in skeletal muscle and lowering of serum glucose levels in type-2 diabetes models. However, direct activation of AMP...

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Autores principales: Sung-Jun Park, Faiyaz Ahmad, Robert J Bahde, Andrew Philp, Jeonghan Kim, Tianjiao Huang, Myung K Kim, William C Trenkle, Jay H Chung
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/feec3c253475457eb9c0174e3e2d56d8
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