Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity

Inhibitory interneurons play important roles in brain circuits and in several neuropsychiatric disorders. Here, the authors show that excitatory synapses onto interneurons vs. excitatory neurons differ in their ambient synaptic glutamate level, a finding with important implications for selective pha...

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Main Authors:	Lulu Yao, Teddy Grand, Jesse E. Hanson, Pierre Paoletti, Qiang Zhou
Format:	article
Language:	EN
Published:	Nature Portfolio 2018
Subjects:	Science Q
Online Access:	https://doaj.org/article/feefe7905a1e4c1d9eb779cab0b0b4a6
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id	oai:doaj.org-article:feefe7905a1e4c1d9eb779cab0b0b4a6
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spelling	oai:doaj.org-article:feefe7905a1e4c1d9eb779cab0b0b4a62021-12-02T16:49:49ZHigher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity10.1038/s41467-018-06512-72041-1723https://doaj.org/article/feefe7905a1e4c1d9eb779cab0b0b4a62018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06512-7https://doaj.org/toc/2041-1723Inhibitory interneurons play important roles in brain circuits and in several neuropsychiatric disorders. Here, the authors show that excitatory synapses onto interneurons vs. excitatory neurons differ in their ambient synaptic glutamate level, a finding with important implications for selective pharmacological targeting of inhibitory neuron NMDA receptors.Lulu YaoTeddy GrandJesse E. HansonPierre PaolettiQiang ZhouNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lulu Yao Teddy Grand Jesse E. Hanson Pierre Paoletti Qiang Zhou Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity
description	Inhibitory interneurons play important roles in brain circuits and in several neuropsychiatric disorders. Here, the authors show that excitatory synapses onto interneurons vs. excitatory neurons differ in their ambient synaptic glutamate level, a finding with important implications for selective pharmacological targeting of inhibitory neuron NMDA receptors.
format	article
author	Lulu Yao Teddy Grand Jesse E. Hanson Pierre Paoletti Qiang Zhou
author_facet	Lulu Yao Teddy Grand Jesse E. Hanson Pierre Paoletti Qiang Zhou
author_sort	Lulu Yao
title	Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity
title_short	Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity
title_full	Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity
title_fullStr	Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity
title_full_unstemmed	Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity
title_sort	higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts nmda receptor activity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/feefe7905a1e4c1d9eb779cab0b0b4a6
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_version_	1718383253821325312

Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity

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