An investigation into the avoidability of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome

Abstract Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rising morbidity amongst hospitalized patients. Whilst clinical protocols for the management of individual DRESS cases have been well established, determination of potential prevention of these cases by utilizing no...

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Autores principales:	Mohammed Ibn-Mas’ud Danjuma, Lina Mohammad Ahmad Naseralallah, Bodoor AbouJabal, Mouhand Faisal Mohamed, Ibrahim Y. Abubeker, Layla Abdul Jabbar, Abdelnaser Elzouki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fef04f6bebf343948c09a4373a777835
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spelling	oai:doaj.org-article:fef04f6bebf343948c09a4373a7778352021-12-02T19:13:48ZAn investigation into the avoidability of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome10.1038/s41598-021-97381-62045-2322https://doaj.org/article/fef04f6bebf343948c09a4373a7778352021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97381-6https://doaj.org/toc/2045-2322Abstract Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rising morbidity amongst hospitalized patients. Whilst clinical protocols for the management of individual DRESS cases have been well established, determination of potential prevention of these cases by utilizing novel “avoidability” tools has remained unexplored. This retrospective study reviewed records of patients who presented to the emergency department of Weill Cornell Medicine-affiliated Hamad General Hospital, Doha Qatar with suspected DRESS syndrome. These cases were independently adjudicated (utilizing the RegiSCAR, and JSCAR tools) as DRESS-drug pairs by a team of two clinical pharmacists and two General Physicians. They were then rated for potential avoidability with the Liverpool adverse drug reactions avoidability tool (LAAT) by the same team of raters. A total of 16 patients satisfied RegiSCAR criteria for DRESS syndrome. The mean age of the study population was 41.5 years (SD ± 13.3). The study population was predominantly male (n = 12; [75%]). The median latent period from drug ingestion to clinical presentation was 14 days (interquartile range [IQR] 6.5, 29). The median RegiSCAR and J-SCAR scores were 6 (IQR 5, 6.8), 5 (IQR 4, 5.8) respectively. Utilizing the LAAT, about 60% of the DRESS syndrome-drug pairs were rated as “avoidable” (“probable” or “definite”). The overall Krippendorf’s alpha with the LAAT was 0.81 (SE 0.10, CI 0.59–1.00); with an intraclass correlation coefficient (ICC) of 0.90 (CI 0.77, 0.96.). In a randomly selected cohort of DRESS syndrome-drug pairs, a significant proportion was potentially avoidable (“possibly” and “definitely”) utilizing the LAAT. This will need validation by larger sample-sized prospective studies utilizing the updated LAAT proposed by this study.Mohammed Ibn-Mas’ud DanjumaLina Mohammad Ahmad NaseralallahBodoor AbouJabalMouhand Faisal MohamedIbrahim Y. AbubekerLayla Abdul JabbarAbdelnaser ElzoukiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mohammed Ibn-Mas’ud Danjuma Lina Mohammad Ahmad Naseralallah Bodoor AbouJabal Mouhand Faisal Mohamed Ibrahim Y. Abubeker Layla Abdul Jabbar Abdelnaser Elzouki An investigation into the avoidability of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome
description	Abstract Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rising morbidity amongst hospitalized patients. Whilst clinical protocols for the management of individual DRESS cases have been well established, determination of potential prevention of these cases by utilizing novel “avoidability” tools has remained unexplored. This retrospective study reviewed records of patients who presented to the emergency department of Weill Cornell Medicine-affiliated Hamad General Hospital, Doha Qatar with suspected DRESS syndrome. These cases were independently adjudicated (utilizing the RegiSCAR, and JSCAR tools) as DRESS-drug pairs by a team of two clinical pharmacists and two General Physicians. They were then rated for potential avoidability with the Liverpool adverse drug reactions avoidability tool (LAAT) by the same team of raters. A total of 16 patients satisfied RegiSCAR criteria for DRESS syndrome. The mean age of the study population was 41.5 years (SD ± 13.3). The study population was predominantly male (n = 12; [75%]). The median latent period from drug ingestion to clinical presentation was 14 days (interquartile range [IQR] 6.5, 29). The median RegiSCAR and J-SCAR scores were 6 (IQR 5, 6.8), 5 (IQR 4, 5.8) respectively. Utilizing the LAAT, about 60% of the DRESS syndrome-drug pairs were rated as “avoidable” (“probable” or “definite”). The overall Krippendorf’s alpha with the LAAT was 0.81 (SE 0.10, CI 0.59–1.00); with an intraclass correlation coefficient (ICC) of 0.90 (CI 0.77, 0.96.). In a randomly selected cohort of DRESS syndrome-drug pairs, a significant proportion was potentially avoidable (“possibly” and “definitely”) utilizing the LAAT. This will need validation by larger sample-sized prospective studies utilizing the updated LAAT proposed by this study.
format	article
author	Mohammed Ibn-Mas’ud Danjuma Lina Mohammad Ahmad Naseralallah Bodoor AbouJabal Mouhand Faisal Mohamed Ibrahim Y. Abubeker Layla Abdul Jabbar Abdelnaser Elzouki
author_facet	Mohammed Ibn-Mas’ud Danjuma Lina Mohammad Ahmad Naseralallah Bodoor AbouJabal Mouhand Faisal Mohamed Ibrahim Y. Abubeker Layla Abdul Jabbar Abdelnaser Elzouki
author_sort	Mohammed Ibn-Mas’ud Danjuma
title	An investigation into the avoidability of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome
title_short	An investigation into the avoidability of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome
title_full	An investigation into the avoidability of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome
title_fullStr	An investigation into the avoidability of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome
title_full_unstemmed	An investigation into the avoidability of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome
title_sort	investigation into the avoidability of drug reaction with eosinophilia and systemic symptoms (dress) syndrome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fef04f6bebf343948c09a4373a777835
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An investigation into the avoidability of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome

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