Long-term progression of visual field defects and related factors in medically treated normal tension glaucoma

Keiji Yoshikawa,1 Kazunori Santo,2 Hiroko Hizaki,2 Masayo Hashimoto2 1Yoshikawa Eye Clinic, Tokyo, 2Medical Affairs, Santen Pharmaceutical Co. Ltd., Osaka, Japan Purpose: To analyze factors related to long-term progression of visual field defects (VFD) in patients with normal tension glaucoma (NTG...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yoshikawa K, Santo K, Hizaki H, Hashimoto M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	long-term follow-up MD slope deterioration consecutive decrease in MD value intraocular pressure reduction Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/fef2542a42ed40c980b800490b62967d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fef2542a42ed40c980b800490b62967d
record_format	dspace
spelling	oai:doaj.org-article:fef2542a42ed40c980b800490b62967d2021-12-02T01:57:34ZLong-term progression of visual field defects and related factors in medically treated normal tension glaucoma1177-5483https://doaj.org/article/fef2542a42ed40c980b800490b62967d2018-01-01T00:00:00Zhttps://www.dovepress.com/long-term-progression-of-visual-field-defects-and-related-factors-in-m-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Keiji Yoshikawa,1 Kazunori Santo,2 Hiroko Hizaki,2 Masayo Hashimoto2 1Yoshikawa Eye Clinic, Tokyo, 2Medical Affairs, Santen Pharmaceutical Co. Ltd., Osaka, Japan Purpose: To analyze factors related to long-term progression of visual field defects (VFD) in patients with normal tension glaucoma (NTG) under medical therapy. Patients and methods: Clinical data from 622 eyes of 311 primary open-angle glaucoma and NTG patients were collected from April 2006 to March 2016. Of these patients, those with normal intraocular pressure (IOP); glaucomatous VFD judged by Anderson’s criteria; corrected visual acuity ≥0.7; receiving more than 6 years medical therapy; having undergone ≥10 visual field tests performed at 6-month intervals using a Humphrey field analyzer (Swedish Interactive Threshold Algorithms standard, C 24-2 program); and having reliability coefficients of visual field testing <33% and mean deviation (MD) more than -20 decibels in the initial visual field test were included in data analysis. The relationship between MD slope deterioration at final observation and consecutive decreases in MD value during the observation period, as well as clinical characteristics and IOP-related factors, were analyzed. Results: Of 134 eyes in 134 NTG patients meeting all eligibility criteria, significant MD slope deterioration was observed in 80 eyes (59.7%). MD slope deterioration was significantly associated with consecutive decreases in MD values (Cochran–Armitage trend test: P=0.0000; univariate logistic regression analysis: P<0.0001). While no significant relationship was observed between central corneal thickness, refractive error, or prevalence of disc hemorrhage, consecutive decreases in MD value was significantly related to MD slope deterioration (univariate logistic regression analysis: P<0.0001). A reduction of IOP during the follow-up period was significantly related to nondeterioration of the MD slope (multivariate logistic regression analysis: P=0.0020). Conclusion: In this 6-year observation of NTG patients treated with medical therapy, the occurrence of three or more consecutive decreases in MD value was significantly associated with visual field deterioration. Reduction in IOP was postulated to be contributing in the prevention of VFD progression. Keywords: long-term follow-up, MD slope deterioration, consecutive decrease in MD value, intraocular pressure reductionYoshikawa KSanto KHizaki HHashimoto MDove Medical Pressarticlelong-term follow-upMD slope deteriorationconsecutive decrease in MD valueintraocular pressure reductionOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 247-253 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	long-term follow-up MD slope deterioration consecutive decrease in MD value intraocular pressure reduction Ophthalmology RE1-994
spellingShingle	long-term follow-up MD slope deterioration consecutive decrease in MD value intraocular pressure reduction Ophthalmology RE1-994 Yoshikawa K Santo K Hizaki H Hashimoto M Long-term progression of visual field defects and related factors in medically treated normal tension glaucoma
description	Keiji Yoshikawa,1 Kazunori Santo,2 Hiroko Hizaki,2 Masayo Hashimoto2 1Yoshikawa Eye Clinic, Tokyo, 2Medical Affairs, Santen Pharmaceutical Co. Ltd., Osaka, Japan Purpose: To analyze factors related to long-term progression of visual field defects (VFD) in patients with normal tension glaucoma (NTG) under medical therapy. Patients and methods: Clinical data from 622 eyes of 311 primary open-angle glaucoma and NTG patients were collected from April 2006 to March 2016. Of these patients, those with normal intraocular pressure (IOP); glaucomatous VFD judged by Anderson’s criteria; corrected visual acuity ≥0.7; receiving more than 6 years medical therapy; having undergone ≥10 visual field tests performed at 6-month intervals using a Humphrey field analyzer (Swedish Interactive Threshold Algorithms standard, C 24-2 program); and having reliability coefficients of visual field testing <33% and mean deviation (MD) more than -20 decibels in the initial visual field test were included in data analysis. The relationship between MD slope deterioration at final observation and consecutive decreases in MD value during the observation period, as well as clinical characteristics and IOP-related factors, were analyzed. Results: Of 134 eyes in 134 NTG patients meeting all eligibility criteria, significant MD slope deterioration was observed in 80 eyes (59.7%). MD slope deterioration was significantly associated with consecutive decreases in MD values (Cochran–Armitage trend test: P=0.0000; univariate logistic regression analysis: P<0.0001). While no significant relationship was observed between central corneal thickness, refractive error, or prevalence of disc hemorrhage, consecutive decreases in MD value was significantly related to MD slope deterioration (univariate logistic regression analysis: P<0.0001). A reduction of IOP during the follow-up period was significantly related to nondeterioration of the MD slope (multivariate logistic regression analysis: P=0.0020). Conclusion: In this 6-year observation of NTG patients treated with medical therapy, the occurrence of three or more consecutive decreases in MD value was significantly associated with visual field deterioration. Reduction in IOP was postulated to be contributing in the prevention of VFD progression. Keywords: long-term follow-up, MD slope deterioration, consecutive decrease in MD value, intraocular pressure reduction
format	article
author	Yoshikawa K Santo K Hizaki H Hashimoto M
author_facet	Yoshikawa K Santo K Hizaki H Hashimoto M
author_sort	Yoshikawa K
title	Long-term progression of visual field defects and related factors in medically treated normal tension glaucoma
title_short	Long-term progression of visual field defects and related factors in medically treated normal tension glaucoma
title_full	Long-term progression of visual field defects and related factors in medically treated normal tension glaucoma
title_fullStr	Long-term progression of visual field defects and related factors in medically treated normal tension glaucoma
title_full_unstemmed	Long-term progression of visual field defects and related factors in medically treated normal tension glaucoma
title_sort	long-term progression of visual field defects and related factors in medically treated normal tension glaucoma
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/fef2542a42ed40c980b800490b62967d
work_keys_str_mv	AT yoshikawak longtermprogressionofvisualfielddefectsandrelatedfactorsinmedicallytreatednormaltensionglaucoma AT santok longtermprogressionofvisualfielddefectsandrelatedfactorsinmedicallytreatednormaltensionglaucoma AT hizakih longtermprogressionofvisualfielddefectsandrelatedfactorsinmedicallytreatednormaltensionglaucoma AT hashimotom longtermprogressionofvisualfielddefectsandrelatedfactorsinmedicallytreatednormaltensionglaucoma
_version_	1718402813463101440

Long-term progression of visual field defects and related factors in medically treated normal tension glaucoma

Ejemplares similares