MICAL2 Promotes Proliferation and Migration of Glioblastoma Cells Through TGF-β/p-Smad2/EMT-Like Signaling Pathway

Recent studies showed that molecule interacting with CasL2 (MICAL2) could be a novel tumor growth factor, and it is closely associated with tumor growth and invasion. However, the role it plays in glioblastoma (GBM) and its potential mechanisms are currently unknown. Our study is designed to identif...

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Autores principales:	Bei Pu, Xu Zhang, Tengfeng Yan, Yuntao Li, Baohui Liu, Zhihong Jian, Omer Kamal Mahgoub, Lijuan Gu, Xiaoxing Xiong, Ning Zou
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	MICAL2 TGF-β EMT proliferation migration Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/fef30f250ac5468a9d79b53d8dee73f2
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spelling	oai:doaj.org-article:fef30f250ac5468a9d79b53d8dee73f22021-11-12T05:07:08ZMICAL2 Promotes Proliferation and Migration of Glioblastoma Cells Through TGF-β/p-Smad2/EMT-Like Signaling Pathway2234-943X10.3389/fonc.2021.735180https://doaj.org/article/fef30f250ac5468a9d79b53d8dee73f22021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.735180/fullhttps://doaj.org/toc/2234-943XRecent studies showed that molecule interacting with CasL2 (MICAL2) could be a novel tumor growth factor, and it is closely associated with tumor growth and invasion. However, the role it plays in glioblastoma (GBM) and its potential mechanisms are currently unknown. Our study is designed to identify the effect of MICAL2 on GBM cells and the potential mechanisms behind it. Here, we found that MICAL2 interacts with TGF receptor-type I (TGFRI) and promotes the proliferation and migration of glioblastoma through the TGF-β/p-Smad2/EMT-like signaling pathway. MICAL2-knockdown inhibited the proliferation of glioblastoma cells, which was related to cell cycle arrest and downregulation of DNA replication. The invasion abilities of U87 and U251 cells were reduced after the knockdown of MICAL2. MICAL2 promoted the growth of GBM in nude mice. High MICAL2 predicts poor outcome of GBM patients. MICAL2 could be identified as a novel promising therapeutic target for human GBM.Bei PuXu ZhangTengfeng YanYuntao LiYuntao LiBaohui LiuZhihong JianOmer Kamal MahgoubLijuan GuXiaoxing XiongXiaoxing XiongNing ZouFrontiers Media S.A.articleMICAL2TGF-βEMTproliferationmigrationNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	MICAL2 TGF-β EMT proliferation migration Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	MICAL2 TGF-β EMT proliferation migration Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Bei Pu Xu Zhang Tengfeng Yan Yuntao Li Yuntao Li Baohui Liu Zhihong Jian Omer Kamal Mahgoub Lijuan Gu Xiaoxing Xiong Xiaoxing Xiong Ning Zou MICAL2 Promotes Proliferation and Migration of Glioblastoma Cells Through TGF-β/p-Smad2/EMT-Like Signaling Pathway
description	Recent studies showed that molecule interacting with CasL2 (MICAL2) could be a novel tumor growth factor, and it is closely associated with tumor growth and invasion. However, the role it plays in glioblastoma (GBM) and its potential mechanisms are currently unknown. Our study is designed to identify the effect of MICAL2 on GBM cells and the potential mechanisms behind it. Here, we found that MICAL2 interacts with TGF receptor-type I (TGFRI) and promotes the proliferation and migration of glioblastoma through the TGF-β/p-Smad2/EMT-like signaling pathway. MICAL2-knockdown inhibited the proliferation of glioblastoma cells, which was related to cell cycle arrest and downregulation of DNA replication. The invasion abilities of U87 and U251 cells were reduced after the knockdown of MICAL2. MICAL2 promoted the growth of GBM in nude mice. High MICAL2 predicts poor outcome of GBM patients. MICAL2 could be identified as a novel promising therapeutic target for human GBM.
format	article
author	Bei Pu Xu Zhang Tengfeng Yan Yuntao Li Yuntao Li Baohui Liu Zhihong Jian Omer Kamal Mahgoub Lijuan Gu Xiaoxing Xiong Xiaoxing Xiong Ning Zou
author_facet	Bei Pu Xu Zhang Tengfeng Yan Yuntao Li Yuntao Li Baohui Liu Zhihong Jian Omer Kamal Mahgoub Lijuan Gu Xiaoxing Xiong Xiaoxing Xiong Ning Zou
author_sort	Bei Pu
title	MICAL2 Promotes Proliferation and Migration of Glioblastoma Cells Through TGF-β/p-Smad2/EMT-Like Signaling Pathway
title_short	MICAL2 Promotes Proliferation and Migration of Glioblastoma Cells Through TGF-β/p-Smad2/EMT-Like Signaling Pathway
title_full	MICAL2 Promotes Proliferation and Migration of Glioblastoma Cells Through TGF-β/p-Smad2/EMT-Like Signaling Pathway
title_fullStr	MICAL2 Promotes Proliferation and Migration of Glioblastoma Cells Through TGF-β/p-Smad2/EMT-Like Signaling Pathway
title_full_unstemmed	MICAL2 Promotes Proliferation and Migration of Glioblastoma Cells Through TGF-β/p-Smad2/EMT-Like Signaling Pathway
title_sort	mical2 promotes proliferation and migration of glioblastoma cells through tgf-β/p-smad2/emt-like signaling pathway
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/fef30f250ac5468a9d79b53d8dee73f2
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MICAL2 Promotes Proliferation and Migration of Glioblastoma Cells Through TGF-β/p-Smad2/EMT-Like Signaling Pathway

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