Doxycycline Combined with NB-UVB Phototherapy for Acquired Reactive Perforating Collagenosis

Limu Gao, Lixiong Gu, Zhen Chen, Shuanglin Cao Department of Dermatology, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, People’s Republic of ChinaCorrespondence: Shuanglin CaoDepartment of Dermatology, Affiliated Hospital of Nantong University, 20th Xisi Road, Nanto...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Gao L, Gu L, Chen Z, Cao S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	acquired reactive perforating collagenosis doxycycline nb-uvb hypertension Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/fef4dd96b93949ab9d52a6d52704e92b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fef4dd96b93949ab9d52a6d52704e92b
record_format	dspace
spelling	oai:doaj.org-article:fef4dd96b93949ab9d52a6d52704e92b2021-12-02T13:04:02ZDoxycycline Combined with NB-UVB Phototherapy for Acquired Reactive Perforating Collagenosis1178-203Xhttps://doaj.org/article/fef4dd96b93949ab9d52a6d52704e92b2020-09-01T00:00:00Zhttps://www.dovepress.com/doxycycline-combined-with-nb-uvb-phototherapy-for-acquired-reactive-pe-peer-reviewed-article-TCRMhttps://doaj.org/toc/1178-203XLimu Gao, Lixiong Gu, Zhen Chen, Shuanglin Cao Department of Dermatology, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, People’s Republic of ChinaCorrespondence: Shuanglin CaoDepartment of Dermatology, Affiliated Hospital of Nantong University, 20th Xisi Road, Nantong, People’s Republic of ChinaEmail slcao@medmail.com.cnBackground: Acquired reactive perforating collagenosis is a rare skin disease characterized by the discharge of collagen fibers through the epidermis. There is no standard treatment for this disease currently. Here, we report a case of ARPC that has been successfully treated and cured.Case Description: A 32-year-old man developed severe itching papules on his torso and limbs for 3 months. Skin lesions were keratotic papules scattered on the limbs and trunk, with a diameter of 3 to 12 mm. Some lesions had umbilical recesses and the shape of a crater with positive isomorphic reactions. The patient scratched his severe itching lesions which merged into large ones. This patient had histories of hypertension and dilated cardiomyopathy with mild congestive heart failure. The clinical presentation and histopathology of skin lesions met Faver’s diagnostic criteria for ARPC.Treatment: Oral Doxycycline 100mg/d, NB-UVB phototherapy 3 times a week with initial dose 400mJ/cm2, gradually increased to 1200mJ/cm2(total cumulative dose 16700J/cm2).Outcomes: After a week of treatment, the patient’s itching symptoms were significantly reduced and stopped presenting any new skin lesions. Most of the lesions healed in 6 weeks of treatment.Lessons: Doxycycline combined with NB-UVB may be an effective treatment for ARPC.Keywords: acquired reactive perforating collagenosis, doxycycline, NB-UVB, hypertensionGao LGu LChen ZCao SDove Medical Pressarticleacquired reactive perforating collagenosisdoxycyclinenb-uvbhypertensionTherapeutics. PharmacologyRM1-950ENTherapeutics and Clinical Risk Management, Vol Volume 16, Pp 917-921 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	acquired reactive perforating collagenosis doxycycline nb-uvb hypertension Therapeutics. Pharmacology RM1-950
spellingShingle	acquired reactive perforating collagenosis doxycycline nb-uvb hypertension Therapeutics. Pharmacology RM1-950 Gao L Gu L Chen Z Cao S Doxycycline Combined with NB-UVB Phototherapy for Acquired Reactive Perforating Collagenosis
description	Limu Gao, Lixiong Gu, Zhen Chen, Shuanglin Cao Department of Dermatology, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, People’s Republic of ChinaCorrespondence: Shuanglin CaoDepartment of Dermatology, Affiliated Hospital of Nantong University, 20th Xisi Road, Nantong, People’s Republic of ChinaEmail slcao@medmail.com.cnBackground: Acquired reactive perforating collagenosis is a rare skin disease characterized by the discharge of collagen fibers through the epidermis. There is no standard treatment for this disease currently. Here, we report a case of ARPC that has been successfully treated and cured.Case Description: A 32-year-old man developed severe itching papules on his torso and limbs for 3 months. Skin lesions were keratotic papules scattered on the limbs and trunk, with a diameter of 3 to 12 mm. Some lesions had umbilical recesses and the shape of a crater with positive isomorphic reactions. The patient scratched his severe itching lesions which merged into large ones. This patient had histories of hypertension and dilated cardiomyopathy with mild congestive heart failure. The clinical presentation and histopathology of skin lesions met Faver’s diagnostic criteria for ARPC.Treatment: Oral Doxycycline 100mg/d, NB-UVB phototherapy 3 times a week with initial dose 400mJ/cm2, gradually increased to 1200mJ/cm2(total cumulative dose 16700J/cm2).Outcomes: After a week of treatment, the patient’s itching symptoms were significantly reduced and stopped presenting any new skin lesions. Most of the lesions healed in 6 weeks of treatment.Lessons: Doxycycline combined with NB-UVB may be an effective treatment for ARPC.Keywords: acquired reactive perforating collagenosis, doxycycline, NB-UVB, hypertension
format	article
author	Gao L Gu L Chen Z Cao S
author_facet	Gao L Gu L Chen Z Cao S
author_sort	Gao L
title	Doxycycline Combined with NB-UVB Phototherapy for Acquired Reactive Perforating Collagenosis
title_short	Doxycycline Combined with NB-UVB Phototherapy for Acquired Reactive Perforating Collagenosis
title_full	Doxycycline Combined with NB-UVB Phototherapy for Acquired Reactive Perforating Collagenosis
title_fullStr	Doxycycline Combined with NB-UVB Phototherapy for Acquired Reactive Perforating Collagenosis
title_full_unstemmed	Doxycycline Combined with NB-UVB Phototherapy for Acquired Reactive Perforating Collagenosis
title_sort	doxycycline combined with nb-uvb phototherapy for acquired reactive perforating collagenosis
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/fef4dd96b93949ab9d52a6d52704e92b
work_keys_str_mv	AT gaol doxycyclinecombinedwithnbuvbphototherapyforacquiredreactiveperforatingcollagenosis AT gul doxycyclinecombinedwithnbuvbphototherapyforacquiredreactiveperforatingcollagenosis AT chenz doxycyclinecombinedwithnbuvbphototherapyforacquiredreactiveperforatingcollagenosis AT caos doxycyclinecombinedwithnbuvbphototherapyforacquiredreactiveperforatingcollagenosis
_version_	1718393544957231104

Doxycycline Combined with NB-UVB Phototherapy for Acquired Reactive Perforating Collagenosis

Ejemplares similares