Differences in heart rate variability and body composition in breast cancer survivors and women without cancer

Abstract The aim of this study was to explore cardiac autonomic changes assessed by linear and nonlinear indexes of heart rate variability (HRV) and body composition modifications in breast cancer survivors and cancer-free control women. Women who were breast cancer survivors (BCS, n = 27) and witho...

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Autores principales:	Daniel Escutia-Reyes, José de Jesús Garduño-García, Gerardo Emilio-López-Chávez, Ángel Gómez-Villanueva, Adriana Cristina Pliego-Carrillo, Alexandra Estela Soto-Piña, José Javier Reyes-Lagos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fef57517a6984b2cb36839623485af81
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spelling	oai:doaj.org-article:fef57517a6984b2cb36839623485af812021-12-02T16:14:17ZDifferences in heart rate variability and body composition in breast cancer survivors and women without cancer10.1038/s41598-021-93713-82045-2322https://doaj.org/article/fef57517a6984b2cb36839623485af812021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93713-8https://doaj.org/toc/2045-2322Abstract The aim of this study was to explore cardiac autonomic changes assessed by linear and nonlinear indexes of heart rate variability (HRV) and body composition modifications in breast cancer survivors and cancer-free control women. Women who were breast cancer survivors (BCS, n = 27) and without cancer with similar characteristics (Control, n = 31) were recruited for this study. We calculated some relevant linear and nonlinear parameters of 5 min of RR interval time series such as mean RR interval (RRave), the corrected Poincaré index (cSD1/SD2), the sample entropy (SampEn), the long-term fractal scaling exponent (α2) and 2UV from symbolic dynamics. Additionally, we indirectly assessed body composition measures such as body weight, fat mass, visceral fat rating (VFR), normalized VRF (nVFR), muscle mass, metabolic age, and total body water. We found that diverse HRV indexes and only one body composition measure showed statistical differences (p < 0.05) between the BCS and Control groups. RRave: 729 (648–802) vs. 795 (713–852) ms; cSD2/SD1: 3.4 (2.7–5.0) vs. 2.9 (2.3–3.5); SampEn: 1.5 (1.3–1.8) vs. 1.7 (1.5–1.8); α2: 0.6 (0.3–0.6) vs. 0.5 (0.4–0.5); 2UV: 7.1 (4.3–11.5) vs. 10.8 (6.4–15.7) and nVFR 0.12 (0.11–0.13) vs. 0.10 (0.08–0.12) points/kg, respectively. The nVFR was strongly significantly correlated with several indexes of HRV only in the BCS group.Our findings suggest that BCS exhibit lower parasympathetic cardiac activity and changes in HRV patterns compared to Controls. A concomitant increase of visceral fat, among other factors, may contribute to cardiac autonomic disturbances and changes in HRV patterns in BCS.Daniel Escutia-ReyesJosé de Jesús Garduño-GarcíaGerardo Emilio-López-ChávezÁngel Gómez-VillanuevaAdriana Cristina Pliego-CarrilloAlexandra Estela Soto-PiñaJosé Javier Reyes-LagosNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daniel Escutia-Reyes José de Jesús Garduño-García Gerardo Emilio-López-Chávez Ángel Gómez-Villanueva Adriana Cristina Pliego-Carrillo Alexandra Estela Soto-Piña José Javier Reyes-Lagos Differences in heart rate variability and body composition in breast cancer survivors and women without cancer
description	Abstract The aim of this study was to explore cardiac autonomic changes assessed by linear and nonlinear indexes of heart rate variability (HRV) and body composition modifications in breast cancer survivors and cancer-free control women. Women who were breast cancer survivors (BCS, n = 27) and without cancer with similar characteristics (Control, n = 31) were recruited for this study. We calculated some relevant linear and nonlinear parameters of 5 min of RR interval time series such as mean RR interval (RRave), the corrected Poincaré index (cSD1/SD2), the sample entropy (SampEn), the long-term fractal scaling exponent (α2) and 2UV from symbolic dynamics. Additionally, we indirectly assessed body composition measures such as body weight, fat mass, visceral fat rating (VFR), normalized VRF (nVFR), muscle mass, metabolic age, and total body water. We found that diverse HRV indexes and only one body composition measure showed statistical differences (p < 0.05) between the BCS and Control groups. RRave: 729 (648–802) vs. 795 (713–852) ms; cSD2/SD1: 3.4 (2.7–5.0) vs. 2.9 (2.3–3.5); SampEn: 1.5 (1.3–1.8) vs. 1.7 (1.5–1.8); α2: 0.6 (0.3–0.6) vs. 0.5 (0.4–0.5); 2UV: 7.1 (4.3–11.5) vs. 10.8 (6.4–15.7) and nVFR 0.12 (0.11–0.13) vs. 0.10 (0.08–0.12) points/kg, respectively. The nVFR was strongly significantly correlated with several indexes of HRV only in the BCS group.Our findings suggest that BCS exhibit lower parasympathetic cardiac activity and changes in HRV patterns compared to Controls. A concomitant increase of visceral fat, among other factors, may contribute to cardiac autonomic disturbances and changes in HRV patterns in BCS.
format	article
author	Daniel Escutia-Reyes José de Jesús Garduño-García Gerardo Emilio-López-Chávez Ángel Gómez-Villanueva Adriana Cristina Pliego-Carrillo Alexandra Estela Soto-Piña José Javier Reyes-Lagos
author_facet	Daniel Escutia-Reyes José de Jesús Garduño-García Gerardo Emilio-López-Chávez Ángel Gómez-Villanueva Adriana Cristina Pliego-Carrillo Alexandra Estela Soto-Piña José Javier Reyes-Lagos
author_sort	Daniel Escutia-Reyes
title	Differences in heart rate variability and body composition in breast cancer survivors and women without cancer
title_short	Differences in heart rate variability and body composition in breast cancer survivors and women without cancer
title_full	Differences in heart rate variability and body composition in breast cancer survivors and women without cancer
title_fullStr	Differences in heart rate variability and body composition in breast cancer survivors and women without cancer
title_full_unstemmed	Differences in heart rate variability and body composition in breast cancer survivors and women without cancer
title_sort	differences in heart rate variability and body composition in breast cancer survivors and women without cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fef57517a6984b2cb36839623485af81
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Differences in heart rate variability and body composition in breast cancer survivors and women without cancer

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