Stabilizing the closed SARS-CoV-2 spike trimer

SARS-CoV-2 S protein prematurely refolds to the post-fusion conformation, compromising immunogenic properties and prefusion trimer yield. Here, Juraszek et al. present a stable SARS-CoV-2 S-closed protein variant with increased expression and correct folding, predominantly in closed prefusion confor...

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Main Authors:	Jarek Juraszek, Lucy Rutten, Sven Blokland, Pascale Bouchier, Richard Voorzaat, Tina Ritschel, Mark J. G. Bakkers, Ludovic L. R. Renault, Johannes P. M. Langedijk
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/fef6c96d1aae41d7a61ebeb8f94b38a6
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spelling	oai:doaj.org-article:fef6c96d1aae41d7a61ebeb8f94b38a62021-12-02T14:11:51ZStabilizing the closed SARS-CoV-2 spike trimer10.1038/s41467-020-20321-x2041-1723https://doaj.org/article/fef6c96d1aae41d7a61ebeb8f94b38a62021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20321-xhttps://doaj.org/toc/2041-1723SARS-CoV-2 S protein prematurely refolds to the post-fusion conformation, compromising immunogenic properties and prefusion trimer yield. Here, Juraszek et al. present a stable SARS-CoV-2 S-closed protein variant with increased expression and correct folding, predominantly in closed prefusion conformation.Jarek JuraszekLucy RuttenSven BloklandPascale BouchierRichard VoorzaatTina RitschelMark J. G. BakkersLudovic L. R. RenaultJohannes P. M. LangedijkNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jarek Juraszek Lucy Rutten Sven Blokland Pascale Bouchier Richard Voorzaat Tina Ritschel Mark J. G. Bakkers Ludovic L. R. Renault Johannes P. M. Langedijk Stabilizing the closed SARS-CoV-2 spike trimer
description	SARS-CoV-2 S protein prematurely refolds to the post-fusion conformation, compromising immunogenic properties and prefusion trimer yield. Here, Juraszek et al. present a stable SARS-CoV-2 S-closed protein variant with increased expression and correct folding, predominantly in closed prefusion conformation.
format	article
author	Jarek Juraszek Lucy Rutten Sven Blokland Pascale Bouchier Richard Voorzaat Tina Ritschel Mark J. G. Bakkers Ludovic L. R. Renault Johannes P. M. Langedijk
author_facet	Jarek Juraszek Lucy Rutten Sven Blokland Pascale Bouchier Richard Voorzaat Tina Ritschel Mark J. G. Bakkers Ludovic L. R. Renault Johannes P. M. Langedijk
author_sort	Jarek Juraszek
title	Stabilizing the closed SARS-CoV-2 spike trimer
title_short	Stabilizing the closed SARS-CoV-2 spike trimer
title_full	Stabilizing the closed SARS-CoV-2 spike trimer
title_fullStr	Stabilizing the closed SARS-CoV-2 spike trimer
title_full_unstemmed	Stabilizing the closed SARS-CoV-2 spike trimer
title_sort	stabilizing the closed sars-cov-2 spike trimer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fef6c96d1aae41d7a61ebeb8f94b38a6
work_keys_str_mv	AT jarekjuraszek stabilizingtheclosedsarscov2spiketrimer AT lucyrutten stabilizingtheclosedsarscov2spiketrimer AT svenblokland stabilizingtheclosedsarscov2spiketrimer AT pascalebouchier stabilizingtheclosedsarscov2spiketrimer AT richardvoorzaat stabilizingtheclosedsarscov2spiketrimer AT tinaritschel stabilizingtheclosedsarscov2spiketrimer AT markjgbakkers stabilizingtheclosedsarscov2spiketrimer AT ludoviclrrenault stabilizingtheclosedsarscov2spiketrimer AT johannespmlangedijk stabilizingtheclosedsarscov2spiketrimer
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Stabilizing the closed SARS-CoV-2 spike trimer

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